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Sleep and Breathing
Published in: Sleep and Breathing 2/2014

01-05-2014 | Original Article

Effect of continuous positive airway pressure on regional cerebral blood flow during wakefulness in obstructive sleep apnea

Authors: Satomi Shiota, Yuichi Inoue, Hidenori Takekawa, Masaki Kotajima, Mami Nakajyo, Chie Usui, Yasuko Yoshioka, Tatsuo Koga, Kazuhisa Takahashi

Published in: Sleep and Breathing | Issue 2/2014

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Abstract

Background

The alteration of regional cerebral blood flow (rCBF) during wakefulness after the treatment for obstructive sleep apnea syndrome (OSA) using continuous positive airway pressure (CPAP) has not been elucidated. The aim of this study was to investigate rCBF characteristics and the effects of nasal CPAP in OSA patients.

Methods

Fifteen severe OSA patients (apnea–hypopnea index, 62.7 ± 22.4/h), when awake, underwent Technetium-99m ethyl cysteinate dimer single photon emission computed tomography before and after CPAP treatment, and the findings were compared to those of nine healthy controls matched for age and sex.

Results

Compared to controls, patients with OSA before CPAP treatment showed a significantly lower rCBF in the frontal lobe. After the treatment, no difference in rCBF was observed between the good CPAP compliance group and the controls. In the former group, there was a positive correlation between the 3 % oxygen desaturation index on diagnostic polysomnogram and the increase of rCBF after CPAP treatment in the frontal lobe.

Conclusions

When awake, patients with severe OSA were shown to have reversible decreases in rCBF, especially in the frontal lobe, and an appropriate CPAP treatment was thought to improve rCBF in this area. Our results support the importance of appropriate CPAP treatment for severe OSA patients.
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Metadata
Title
Effect of continuous positive airway pressure on regional cerebral blood flow during wakefulness in obstructive sleep apnea
Authors
Satomi Shiota
Yuichi Inoue
Hidenori Takekawa
Masaki Kotajima
Mami Nakajyo
Chie Usui
Yasuko Yoshioka
Tatsuo Koga
Kazuhisa Takahashi
Publication date
01-05-2014
Publisher
Springer Berlin Heidelberg
Published in
Sleep and Breathing / Issue 2/2014
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-013-0881-9

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