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Clinical Orthopaedics and Related Research®
Published in: Clinical Orthopaedics and Related Research® 8/2015

01-08-2015 | Symposium: Sex Differences in Musculoskeletal Disease and Science

Editorial Comment: Symposium: Sex Differences in Musculoskeletal Disease and Science

Authors: Karl J. Jepsen, PhD, Nancy E. Lane, MD, John H. Healey, MD, Laura L. Tosi, MD

Published in: Clinical Orthopaedics and Related Research® | Issue 8/2015

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Excerpt

The US Public Health Service noted in 1985 that lack of knowledge about female biology compromises the health of women. But until the 1990s, biomedical research was primarily rooted in the male model—the belief that male biology (outside of the reproductive system) was representative of the species. In 1993, Congress passed the NIH Revitalization Act, mandating that women and minorities be included in all clinical research, and requiring that Phase III clinical trials be analyzed by sex. Subsequently, a 2001 Institute of Medicine (IOM) report [1] unequivocally stated that “every cell has a sex,” and research should take sex differences into consideration from “womb to tomb.” …
Literature
1.
Institute of Medicine (US) Committee on Understanding the Biology of Sex and Gender Differences. Exploring the Biological Contributions to Human Health: Does Sex Matter? Washington, DC: National Academy Press; 2001.
2.
Leopold SS, Beadling L, Dobbs MB, Gebhardt MC, Lotke PA, Manner PA, Rimnac CM, Wongworawat MD. Fairness to all: Gender and sex in scientific reporting. Clin Orthop Relat Res. 2014;472:391–392.PubMedCentralPubMedCrossRef
3.
Tosi LL, Boyan BD, Boskey AL. Does sex matter in musculoskeletal health? J Bone Joint Surg Am. 2005;87-A:1631–1647.
Metadata
Title
Editorial Comment: Symposium: Sex Differences in Musculoskeletal Disease and Science
Authors
Karl J. Jepsen, PhD
Nancy E. Lane, MD
John H. Healey, MD
Laura L. Tosi, MD
Publication date
01-08-2015
Publisher
Springer US
Published in
Clinical Orthopaedics and Related Research® / Issue 8/2015
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-015-4368-9

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