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Published in: Journal of Medical Case Reports 1/2022

Open Access 01-12-2022 | Edema | Case report

Remitting seronegative symmetrical synovitis with pitting edema: a case report

Authors: Yasushi Tanaka, Kohki Kohchi, Kazuhiro Kitamoto

Published in: Journal of Medical Case Reports | Issue 1/2022

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Abstract

Background

Edema occurs in various disorders. One of those is remitting seronegative symmetrical synovitis with pitting edema, a rare syndrome whose pathophysiology is not clearly understood. We report herein a case of refractory edema diagnosed as remitting seronegative symmetrical synovitis with pitting edema.

Case presentation

A 82-year-old Asian male was admitted to the Department of General Internal Medicine with a 2-month history of symmetrical swelling of both hands. Despite treatment with loop diuretic furosemide 40 mg daily, his condition did not respond to the medication and his quality of life deteriorated. An examination of the joints showed tenderness suggestive of synovitis with restricted movements in bilateral proximal interphalangeal joint. Laboratory findings revealed hyperglycemia, elevated erythrocyte sedimentation rate 118 mm/hour, and elevated C-reactive protein 6.58 mg/dL. Plain radiographs of both hands showed soft tissue swelling, changes consistent with osteoarthritis, and no erosions. The diagnosis of bilateral remitting seronegative symmetrical synovitis with pitting edema was made. Treatment with prednisolone 15 mg daily was instituted.

Conclusions

Although remitting seronegative symmetrical synovitis with pitting edema is rare, it should be remembered as a disease that causes edema in the elderly.
Literature
1.
go back to reference O’Brien JG, Chennubhotla SA, Chennubhotla RV. Treatment of edema. Am Fam Phys. 2005;71:2111–7. O’Brien JG, Chennubhotla SA, Chennubhotla RV. Treatment of edema. Am Fam Phys. 2005;71:2111–7.
2.
go back to reference McCarty DJ, O’Duffy JD, Pearson L, Hunter JB. Remitting seronegative symmetrical synovitis with pitting edema. RS3PE syndrome. JAMA. 1985;254:2763–7.PubMedCrossRef McCarty DJ, O’Duffy JD, Pearson L, Hunter JB. Remitting seronegative symmetrical synovitis with pitting edema. RS3PE syndrome. JAMA. 1985;254:2763–7.PubMedCrossRef
3.
4.
go back to reference Tabeya T, Sugaya T, Suzuki C, Yamamoto M, Kanaseki T, Shinomura Y, et al. A case of angioimmunoblastic T-cell lymphoma with high serum VEGF preceded by RS3PE syndrome. Mod Rheumatol. 2016;26:281–5.PubMedCrossRef Tabeya T, Sugaya T, Suzuki C, Yamamoto M, Kanaseki T, Shinomura Y, et al. A case of angioimmunoblastic T-cell lymphoma with high serum VEGF preceded by RS3PE syndrome. Mod Rheumatol. 2016;26:281–5.PubMedCrossRef
5.
go back to reference Bucaloiu ID, Olenginski TP, Harrington TM. Remitting seronegative symmetrical synovitis with pitting edema syndrome in a rural tertiary care practice: a retrospective analysis. Mayo Clin Proc. 2007;82:1510–5.PubMedCrossRef Bucaloiu ID, Olenginski TP, Harrington TM. Remitting seronegative symmetrical synovitis with pitting edema syndrome in a rural tertiary care practice: a retrospective analysis. Mayo Clin Proc. 2007;82:1510–5.PubMedCrossRef
Metadata
Title
Remitting seronegative symmetrical synovitis with pitting edema: a case report
Authors
Yasushi Tanaka
Kohki Kohchi
Kazuhiro Kitamoto
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2022
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-022-03310-0

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