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Archives of Gynecology and Obstetrics

29-04-2024 | Ectopic Pregnancy | General Gynecology

The relationship between serum levels of epidermal growth factor and β-human chorionic gonadotropin and the type and prognosis of ectopic pregnancy

Authors: Dandan Geng, Manfang Liu, Dongyan Wu, Benming Yue

Published in: Archives of Gynecology and Obstetrics

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Abstract

Purpose

This work aimed to explore the relationship between epidermal growth factor (EGF) and β-human chorionic gonadotropin (β-HCG) and ectopic pregnancy types and impact on prognosis.

Methods

Twenty women with normal pregnancies (NPs) were recruited as control group, and twenty women each with tubal pregnancy (TP) and cervical pregnancy (CP) were recruited. Blood samples were collected to detect EGF and β-HCG. Data on length of hospital stay and incidence of complications were collected. The differences in serum EGF and β-HCG levels were compared among groups and within various types of ectopic pregnancy using analysis of variance and Pearson correlation analysis.

Results

Serum EGF and β-HCG were notably lower in TP and CP group vs. controls (P < 0.05). In subgroup analysis within the types of ectopic pregnancy, serum EGF levels were drastically higher in TP group vs. CP group (P < 0.05). Serum EGF levels were negatively correlated with pregnancy outcomes and incidence of complications (P < 0.05). In patients with TP and CP, serum EGF and β-HCG recovery time and hospital stay differed drastically (P < 0.05). Serum EGF and β-HCG levels showed optimal cutoff values identified at 2.65 μg/L and 11,745.35 IU/L, respectively. The corresponding area under the curve (AUC) values were 0.885 and 0.841.

Conclusion

Elevated levels of EGF may be associated with the occurrence of ectopic pregnancy and may impact the type of ectopic pregnancy, pregnancy outcomes, and the incidence of complications. Further clinical research is warranted to investigate these findings.
Literature
1.
Hendriks E, Rosenberg R, Prine L (2020) Ectopic pregnancy: diagnosis and management. Am Fam Physician 101(10):599–606PubMed
2.
Leziak M, Żak K, Frankowska K et al (2022) Future perspectives of ectopic pregnancy treatment-review of possible pharmacological methods. Int J Environ Res Public Health 19(21):14230CrossRefPubMedPubMedCentral
3.
Scibetta EW, Han CS (2019) Ultrasound in early pregnancy: viability, unknown locations, and ectopic pregnancies. Obstet Gynecol Clin North Am 46(4):783–795CrossRefPubMed
4.
Sun XY, Liang Z (2021) Effect of drug therapy on pregnancy rate, sex hormone levels and adverse reactions after laparoscopic surgery in patients with endometriosis and infertility. J Biol Regul Homeost Agents 35(1):191–196PubMed
5.
Moussa B, Serge TAE, David L et al (2022) Ectopic pregnancy: epidemiological, clinical, therapeutical, anatomopathological aspects and prognosis at the Department of Obstetrics and Gynecology of the Teaching Hospital Souro Sanou of Bobo-Dioulasso: about 79 cases and literature review. Open J Obstet Gynecol 12(1):1–10CrossRef
6.
Hengrui L (2020) The role of transient receptor potential melastatin 7 (TRPM7) in cell viability: a potential target to suppress breast cancer cell cycle. J Cancers. 12(1):131CrossRef
7.
Sharma SSS (2020) The prevalence and epidemiology of ectopic pregnancies in SMGS: a tertiary health care hospital in Jammu, India. Int J Reprod Med Gynecol 6(1):025–030
8.
Hengrui L (2022) A comprehensive bioinformatic analysis of cyclin-dependent kinase 2 (CDK2) in glioma. J Gene 822:146325CrossRef
9.
Zhang Q, Xing X, Liu S et al (2019) Intramural ectopic pregnancy following pelvic adhesion: case report and literature review. Arch Gynecol Obstet 300(6):1507–1520CrossRefPubMed
10.
Ozcan MCH, Wilson JR, Frishman GN (2021) A systematic review and meta-analysis of surgical treatment of ectopic pregnancy with salpingectomy versus salpingostomy. J Minim Invasive Gynecol 28(3):656–667CrossRefPubMed
11.
Harrison PT, Vyse S, Huang PH (2020) Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer. Semin Cancer Biol 61:167–179CrossRefPubMedPubMedCentral
12.
Marcella F (2012) Epidermal growth factor receptor (EGFR) gene copy number in colorectal adenoma-carcinoma progression. J Cancer genetics 205(12):630–635CrossRef
13.
Martinelli E, Ciardiello D, Martini G et al (2020) Implementing anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer: challenges and future perspectives. Ann Oncol 31(1):30–40CrossRefPubMed
14.
Hosomi Y, Morita S, Sugawara S et al (2020) Gefitinib alone vs. gefitinib plus chemotherapy for non-small-cell lung cancer with mutated epidermal growth factor receptor: NEJ009 study. J Clin Oncol 38(2):115–123CrossRefPubMed
15.
Gelatti ACZ, Drilon A, Santini FC (2019) Optimizing the sequencing of tyrosine kinase inhibitors (TKIs) in epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). Lung Cancer 137:113–122CrossRefPubMed
16.
Sonja M (2022) Analysis of polymorphisms in EGF, EGFR and HER2 genes in pancreatic neuroendocrine tumors (PNETs). J Cancer Genet 266–267:44–50
17.
Sabbioni L, Carossino E, Severi FM, Luisi S (2019) From β-hCG values to counseling in tubal pregnancy: what do women want? Gynecol Endocrinol 35(12):1021–1026CrossRefPubMed
18.
Zhang Y, Li Z, Ren B et al (2022) Diagnostic value of a single β-hCG test in predicting reproductive outcomes in women undergoing cleavage embryo transfer: a retrospective analysis from a single center. Reprod Health 19(1):145CrossRefPubMedPubMedCentral
19.
Wu W, Gao H, Li X et al (2019) β-hCG promotes epithelial ovarian cancer metastasis through ERK/MMP2 signaling pathway. Cell Cycle 18(1):46–59CrossRefPubMed
20.
Zhang J, Zhang Y, Gan L et al (2020) Predictors and clinical features of methotrexate (MTX) therapy for ectopic pregnancy. BMC Pregnancy Childbirth 20(1):654CrossRefPubMedPubMedCentral
21.
Besharati R, Lashkardoost H, Hamedi A et al (2020) Prevalence of Chlamydia trachomatis infection with ELISA method and its related factors in women with a history of abortion referred to Bental-Hoda hospital. Iran J Obstet Gynecol Infert 23(8):30–36
22.
Ma L, Li Z, Xi S et al (2020) Tubal ectopic pregnancy occurrence is associated with high expressions of prokineticin receptors and aberrant secretion of inflammatory cytokines. Am J Transl Res 12(9):5741–5751PubMedPubMedCentral
23.
Liu X, Qu P, Bai H et al (2019) Endometrial thickness as a predictor of ectopic pregnancy in 1125 in vitro fertilization-embryo transfer cycles: a matched case-control study. Arch Gynecol Obstet 300(6):1797–1803CrossRefPubMed
24.
Bai X, Liu J, Cao S, Wang L (2019) Mechanisms of endometrial fibrosis and the potential application of stem cell therapy. Discov Med 27(150):267–279PubMed
25.
Zhang L, Zeng L, Liu H et al (2022) Effects of oocyte cytoplasmic central granulation on embryonic development, blastocyst formation, and pregnancy outcome in assisted reproductive technology and its mechanism. Cell Mol Biol (Noisy-le-grand) 68(5):161–169CrossRefPubMed
26.
Zahraasgari FT, Hosseini R, Tavoli Z et al (2019) Ovarian reserve after laparoscopic salpingectomy compared with laparoscopic salpingotomy in patients with tubal ectopic pregnancy. Acta Medica 35:967
27.
Hendriks E, MacNaughton H, MacKenzie MC (2019) First trimester bleeding: evaluation and management. Am Fam Physician 99(3):166–174PubMed
28.
Parker AL, CRNFA C (2022) Assessment and management of vaginal bleeding in early pregnancy. Women’s Healthc: Clin Jr NPs 10(4):9–28
29.
Furkatovna AM, Dilmurod o’g KUB (2023) New approaches to rehabilitation after ectopic pregnancy. Central Asian J Med Nat Sci 4(2):282–285
30.
Horne AW, Tong S, Moakes CA et al (2023) Combination of gefitinib and methotrexate to treat tubal ectopic pregnancy (GEM3): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 401(10377):655–663CrossRefPubMed
31.
Whigham CA, MacDonald TM, Walker SP et al (2019) The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development. Placenta 84:28–31CrossRefPubMed
32.
Zhan H, Peng B, Ma J et al (2020) Epidermal growth factor promotes stromal cells migration and invasion via up-regulation of hyaluronate synthase 2 and hyaluronan in endometriosis. Fertil Steril 114(4):888–898CrossRefPubMed
33.
Cakhantara A, Prabawa A (2019) Molecular therapy for ectopic pregnancy. Bali Anat J 2(2):38–39CrossRef
34.
Roy A, Patra SK (2023) Lipid raft facilitated receptor organization and signaling: a functional rheostat in embryonic development, stem cell biology and cancer. Stem Cell Rev Rep 19(1):2–25CrossRefPubMed
35.
Ma D, Yang R, Chen Y et al (2022) Identification of noninvasive diagnostic biomarkers for ectopic pregnancy using data-independent acquisition (DIA)proteomics: a pilot study. Sci Rep 12(1):19992CrossRefPubMedPubMedCentral
36.
37.
Zhu W, Yeung Q, Chan D et al (2019) Maternal β-HCG concentrations in early IVF pregnancy: association with the embryo development stage of blastocysts. Reprod Biomed Online 38(5):683–690CrossRefPubMed
38.
Jing G, Yao J, Dang Y et al (2021) The role of β-HCG and VEGF-MEK/ERK signaling pathway in villi angiogenesis in patients with missed abortion. Placenta 103:16–23CrossRefPubMed
39.
Sorrentino F, Vasciaveo L, De Feo V et al (2022) Interstitial pregnancy treated with mifepristone and methotrexate with high serum β-hCG level in a patient wishing to preserve fertility: time to define standardized criteria for medical/surgical therapy? Int J Environ Res Public Health 19(18):11464CrossRefPubMedPubMedCentral
Metadata
Title
The relationship between serum levels of epidermal growth factor and β-human chorionic gonadotropin and the type and prognosis of ectopic pregnancy
Authors
Dandan Geng
Manfang Liu
Dongyan Wu
Benming Yue
Publication date
29-04-2024
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-024-07523-0