Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 3/2005

01-03-2005 | Image of the Month

ECG-triggered high-resolution positron emission tomography: a breakthrough in cardiac molecular imaging of mice

Authors: Klaus P. Schäfers, Lars Stegger, Cameron Barnard, Michael Kriens, Sven Hermann, Otmar Schober, Michael Schäfers

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2005

Login to get access

Excerpt

Molecular imaging by small animal positron emission tomography (PET) is an important non-invasive means to phenotype transgenic and knockout mouse models in vivo. However, the quality of non-gated cardiac PET imaging is degraded by heart movement and respiration, reducing both the spatial resolution of the images and the accuracy of quantification. Here we present a breakthrough in the field of PET mouse imaging: the successful ECG-triggered gated PET imaging of a mouse heart. This method has the potential to dramatically improve the image quality of cardiac small animal PET and to assess molecular pathways and parameters of cardiac function such as cardiac volumes and ejection fraction in a single scan. …
Appendix
Available only for authorised users
Literature
1.
Jeavons AP, Chandler RA, Dettmar CAR. A 3D HIDAC-PET camera with sub-millimetre resolution for imaging small animals. IEEE Trans Nucl Sci 1999;46:468–73.CrossRef
2.
Reader AJ, Ally S, Bakatselos F, et al. One-pass list-mode EM algorithm for high resolution 3D PET image reconstruction into large arrays. IEEE Trans Nucl Sci 2002;49:693–9.CrossRef
3.
Stegger L, Biedenstein S, Schäfers KP, et al. Elastic surface contour detection for the measurement of ejection fraction in myocardial perfusion SPET. Eur J Nucl Med 2001;28:48–55.
Metadata
Title
ECG-triggered high-resolution positron emission tomography: a breakthrough in cardiac molecular imaging of mice
Authors
Klaus P. Schäfers
Lars Stegger
Cameron Barnard
Michael Kriens
Sven Hermann
Otmar Schober
Michael Schäfers
Publication date
01-03-2005
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2005
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-004-1628-4

Other articles of this Issue 3/2005

European Journal of Nuclear Medicine and Molecular Imaging 3/2005 Go to the issue

Erratum

Tetrahydrobiopterin restores impaired coronary microvascular dysfunction in hypercholesterolaemia

News & Views

March 2005

Original Article

Differences in [99mTc]TRODAT-1 SPECT binding to dopamine transporters in patients with multiple system atrophy and Parkinson’s disease

Original Article

Cell death triggered by alpha-emitting 213Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death

Review Article

Genetic and epigenetic features in radiation sensitivity

Image of the Month

18F-FDG uptake in bilateral adrenal hyperplasia causing Cushing’s syndrome