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01-09-2017 | Original Contributions

Early Weight Loss Independent Effects of Sleeve Gastrectomy on Diet-Induced Cardiac Dysfunction in Obese, Wistar Rats

Authors: Tammy L. Kindel, Tom Foster, Paul Goldspink, Steven J. Kindel, John Corbett, Michael Widlanksy, Jennifer Strande

Published in: Obesity Surgery | Issue 9/2017

Abstract

Introduction

Several reports suggest that bariatric surgery significantly improves cardiac function in patients with obesity cardiomyopathy. The mechanism is unknown but may be due to weight-loss independent factors. We predict that the changes in gastrointestinal anatomy after a rodent model of sleeve gastrectomy (SG) will have weight-loss independent effects on cardiac dysfunction.

Methodology

Cardiac dysfunction was induced by feeding a 60% kcal from fat diet to male Wistar rats for 10 weeks. Rats underwent either a SG (n = 12) or pair-fed, PF (n = 8) sham surgery. Echocardiograms were performed pre- and post-operatively at 6 and 13 weeks. Blood samples were obtained at 10 weeks post-operatively for assessment of insulin sensitivity and heart failure.

Results

Forty-four percent of SG rats had a normal ejection fraction (EF) at 13 weeks (“responders”) compared to five SG rats who did not recover EF (“non-responders”). Zero percent of the PF rats normalized EF (p = 0.03). SG responders had a smaller left ventricular internal diameter in systole and end systolic volume with improved systolic function compared to SG non-responders (EF 90.7 ± 1.7 vs. 75.4 ± 3.6%, p = <0.001). At 10 weeks post-operatively, plasma glucose and B-type natriuretic peptide levels were significantly lower in SG rats compared to PF rats.

Conclusions

A SG significantly improved systolic function in 44% of rats with diet-induced obesity and cardiac dysfunction. This improvement is related to weight-loss independent effects of the surgery on the entero-cardiac axis. These results offer a novel weight-loss independent, metabolic role for bariatric surgery as a potential treatment modality for obesity-associated cardiac dysfunction.

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Title: Early Weight Loss Independent Effects of Sleeve Gastrectomy on Diet-Induced Cardiac Dysfunction in Obese, Wistar Rats
Authors: Tammy L. Kindel
Tom Foster
Paul Goldspink
Steven J. Kindel
John Corbett
Michael Widlanksy
Jennifer Strande
Publication date: 01-09-2017
Publisher: Springer US
Published in: Obesity Surgery / Issue 9/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-017-2632-7

At a glance: The STEP trials

Springer Medicine

Early Weight Loss Independent Effects of Sleeve Gastrectomy on Diet-Induced Cardiac Dysfunction in Obese, Wistar Rats

Abstract

Introduction

Methodology

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methodology

Results

Conclusions

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