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Published in: Pediatric Nephrology 4/2010

01-04-2010 | Review

Early vascular phenotypes in the genesis of hypertension

Authors: Empar Lurbe, Maria Isabel Torró

Published in: Pediatric Nephrology | Issue 4/2010

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Abstract

Cardiovascular complications occurring in adults find their roots in risk factors operating early in life. Among the factors influencing cardiovascular risk, blood pressure values in children represent an important measurable marker of the level of potential cardiovascular risk later in life because the levels are both the cause and the consequence of early vascular alterations. Early vascular phenotypes represent a field of great interest, and they can be studied through indirect assessment using non-invasive techniques. Estimations of blood pressure components, pulse wave velocity, and reflecting waves provide valuable information that can be easily recorded and repeated over time. A direct assessment, carried out by examining the umbilical vessels, can add further valuable information. In this review, we discuss the potential application of surrogate markers of early vascular alterations and describe the information provided by umbilical cord vessels.
Literature
1.
go back to reference Barker DJ (ed) (1992) Fetal and infant origins of adult disease, 1st edn. BMJ Books, London Barker DJ (ed) (1992) Fetal and infant origins of adult disease, 1st edn. BMJ Books, London
3.
go back to reference Nilsson PM, Lurbe E, Laurent S (2008) The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome. J Hypertens 26:1049–1057CrossRefPubMed Nilsson PM, Lurbe E, Laurent S (2008) The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome. J Hypertens 26:1049–1057CrossRefPubMed
4.
go back to reference Lurbe E, Garcia-Vicent C, Torro I, Fayos JL, Aguilar F, de Llano JM, Fuertes G, Redón J (2007) First-year blood pressure increase steepest in low birthweight newborns. J Hypertens 25:81–86CrossRefPubMed Lurbe E, Garcia-Vicent C, Torro I, Fayos JL, Aguilar F, de Llano JM, Fuertes G, Redón J (2007) First-year blood pressure increase steepest in low birthweight newborns. J Hypertens 25:81–86CrossRefPubMed
5.
go back to reference Barker DJ, Osmond C, Forsén TJ, Kajantie E, Eriksson JG (2005) Trajectories of growth among children who have coronary events as adults. N Engl J Med 353:1802–1809CrossRefPubMed Barker DJ, Osmond C, Forsén TJ, Kajantie E, Eriksson JG (2005) Trajectories of growth among children who have coronary events as adults. N Engl J Med 353:1802–1809CrossRefPubMed
6.
go back to reference O'Rourke MF, Hashimoto J (2007) Mechanical factors in arterial aging. A clinical perspective. J Am Coll Cardiol 50:1–13CrossRefPubMed O'Rourke MF, Hashimoto J (2007) Mechanical factors in arterial aging. A clinical perspective. J Am Coll Cardiol 50:1–13CrossRefPubMed
7.
go back to reference Franklin SS, Khan SA, Wong ND, Larson MG, Levy D (1999) Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study. Circulation 100:354–360PubMed Franklin SS, Khan SA, Wong ND, Larson MG, Levy D (1999) Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study. Circulation 100:354–360PubMed
8.
go back to reference Wilkinson IB, Fuchs SA, Jansen IM, Spratt JC, Murray GD, Cockcroft JR, Webb DJ (1998) The reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis. J Hypertens 16:2079–2084CrossRefPubMed Wilkinson IB, Fuchs SA, Jansen IM, Spratt JC, Murray GD, Cockcroft JR, Webb DJ (1998) The reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis. J Hypertens 16:2079–2084CrossRefPubMed
9.
go back to reference Chen CH, Nevo E, Fetics B, Pak PH, Yin FCP, Maughan WL, Kass DA (1997) Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure: validation of generalized transfer function. Circulation 95:1827–1836PubMed Chen CH, Nevo E, Fetics B, Pak PH, Yin FCP, Maughan WL, Kass DA (1997) Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure: validation of generalized transfer function. Circulation 95:1827–1836PubMed
10.
go back to reference Weber T, Ammer M, Rammer M, Adji A, O'Rourke MF, Wassertheurer S, Rosenkranz S, Eber B (2009) Noninvasive determination of carotid-femoral pulse wave velocity depends critically on assessment of travel distance: a comparison with invasive measurement. J Hypertens 27:1624–1630CrossRefPubMed Weber T, Ammer M, Rammer M, Adji A, O'Rourke MF, Wassertheurer S, Rosenkranz S, Eber B (2009) Noninvasive determination of carotid-femoral pulse wave velocity depends critically on assessment of travel distance: a comparison with invasive measurement. J Hypertens 27:1624–1630CrossRefPubMed
11.
go back to reference Lurbe E, Torro MI, Carvajal E, Alvarez V, Redón J (2003) Birth weight impacts on wave reflections in children and adolescents. Hypertension 41:646–650CrossRefPubMed Lurbe E, Torro MI, Carvajal E, Alvarez V, Redón J (2003) Birth weight impacts on wave reflections in children and adolescents. Hypertension 41:646–650CrossRefPubMed
12.
go back to reference Karamanoglu M, Gallagher DE, Avolio AP, O’Rourke MF (1995) Pressure wave propagation in a multibranched model of the human upper-limb. Am J Physiol 269:H1363–H1369PubMed Karamanoglu M, Gallagher DE, Avolio AP, O’Rourke MF (1995) Pressure wave propagation in a multibranched model of the human upper-limb. Am J Physiol 269:H1363–H1369PubMed
13.
go back to reference Takazawa K, O’Rourke M, Fujita M, Tanaka N, Takeda K, Kurosu F, Ibukiyama C (1996) Estimation of ascending aortic pressure from radial arterial pressure using a generalized transfer function. Z Kardiol 85[Suppl 3]:137–139PubMed Takazawa K, O’Rourke M, Fujita M, Tanaka N, Takeda K, Kurosu F, Ibukiyama C (1996) Estimation of ascending aortic pressure from radial arterial pressure using a generalized transfer function. Z Kardiol 85[Suppl 3]:137–139PubMed
14.
go back to reference Lurbe E, Torro I, Rodríguez C, Alvarez V, Redón J (2001) Birth weight influences blood pressure values and variability in children and adolescents. Hypertension 38:389–393PubMed Lurbe E, Torro I, Rodríguez C, Alvarez V, Redón J (2001) Birth weight influences blood pressure values and variability in children and adolescents. Hypertension 38:389–393PubMed
15.
go back to reference Lurbe E, Torró I, Alvarez V, Aguilar F, Redon J (2004) The impact of birth weight in pulse pressure during adolescence. Blood Press Monit 9:187–192CrossRefPubMed Lurbe E, Torró I, Alvarez V, Aguilar F, Redon J (2004) The impact of birth weight in pulse pressure during adolescence. Blood Press Monit 9:187–192CrossRefPubMed
16.
go back to reference Martyn CN, Barker DJP, Jespersen S, Greenwald S, Osmond C, Berry C (1995) Growth in utero, adult blood pressure and arterial compliance. Br Heart J 73:116–121CrossRefPubMed Martyn CN, Barker DJP, Jespersen S, Greenwald S, Osmond C, Berry C (1995) Growth in utero, adult blood pressure and arterial compliance. Br Heart J 73:116–121CrossRefPubMed
17.
go back to reference Aviv A (2001) Pulse pressure and human longevity. Hypertension 37:1060–1066PubMed Aviv A (2001) Pulse pressure and human longevity. Hypertension 37:1060–1066PubMed
18.
go back to reference Segar JL, Robillard JE (2004) Neurohumoral regulation of blood pressure in early development. In: Portman R, Sorof J, Ingelfinger JR (eds) Pediatric hypertension. Humana Press, Totowa, pp 3–21 Segar JL, Robillard JE (2004) Neurohumoral regulation of blood pressure in early development. In: Portman R, Sorof J, Ingelfinger JR (eds) Pediatric hypertension. Humana Press, Totowa, pp 3–21
19.
go back to reference Andriessen P, Koleen AM, Berendsen RC, Wijn PF, ten Broeke ED, Oei SG, Blanco CE (2003) Cardiovascular fluctuations and transfer function analysis in stable preterm infants. Pediatr Res 53:89–97PubMed Andriessen P, Koleen AM, Berendsen RC, Wijn PF, ten Broeke ED, Oei SG, Blanco CE (2003) Cardiovascular fluctuations and transfer function analysis in stable preterm infants. Pediatr Res 53:89–97PubMed
20.
go back to reference Jaffe EA, Nachman RL, Becker CG, Minick CR (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52:2745–2756CrossRefPubMed Jaffe EA, Nachman RL, Becker CG, Minick CR (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52:2745–2756CrossRefPubMed
21.
go back to reference Mano Y, Sawasaki Y, Takahashi K, Goto T (1983) Cultivation of arterial endothelial cells from human umbilical cord. Experientia 39:1144–1146CrossRefPubMed Mano Y, Sawasaki Y, Takahashi K, Goto T (1983) Cultivation of arterial endothelial cells from human umbilical cord. Experientia 39:1144–1146CrossRefPubMed
22.
go back to reference Dunzendorfer S, Bellmann R, Wiedermann C (1999) A simple way to obtain sufficient amounts of arterial endothelial cells from human umbilical cords. Cell Biol Int 23:89–90CrossRefPubMed Dunzendorfer S, Bellmann R, Wiedermann C (1999) A simple way to obtain sufficient amounts of arterial endothelial cells from human umbilical cords. Cell Biol Int 23:89–90CrossRefPubMed
23.
go back to reference Ulrich-Merzenich G, Metzzner C, Bhonde RR, Malsch G, Schiermeyer B, Vetter H (2002) Simultaneous isolation of endothelial and smooth muscle cells from human umbilical artery or vein and their growth response to low-density lipoproteins. In Vitro Cell Dev Biol Anim 38:265–272CrossRefPubMed Ulrich-Merzenich G, Metzzner C, Bhonde RR, Malsch G, Schiermeyer B, Vetter H (2002) Simultaneous isolation of endothelial and smooth muscle cells from human umbilical artery or vein and their growth response to low-density lipoproteins. In Vitro Cell Dev Biol Anim 38:265–272CrossRefPubMed
24.
go back to reference Martín de Llano JJ, Fuertes G, Torró I, García Vicent C, Fayos JL, Lurbe E (2009) Birth weight and characteristics of endothelial and smooth muscle cell cultures from human umbilical cord vessels. J Transl Med 7:30CrossRefPubMed Martín de Llano JJ, Fuertes G, Torró I, García Vicent C, Fayos JL, Lurbe E (2009) Birth weight and characteristics of endothelial and smooth muscle cell cultures from human umbilical cord vessels. J Transl Med 7:30CrossRefPubMed
25.
go back to reference Jaddoe VW, Witteman JC (2006) Hypotheses on the fetal origins of adult diseases: contributions of epidemiological studies. Eur J Epidemiol 21:91–102CrossRefPubMed Jaddoe VW, Witteman JC (2006) Hypotheses on the fetal origins of adult diseases: contributions of epidemiological studies. Eur J Epidemiol 21:91–102CrossRefPubMed
26.
go back to reference Seckl JR, Holmes MC (2007) Mechanisms of disease: glucocorticoids, their placental metabolism and fetal ‘programming’ of adult pathophysiology. Nat Clin Pract Endocrinol Metab 3:479–488CrossRefPubMed Seckl JR, Holmes MC (2007) Mechanisms of disease: glucocorticoids, their placental metabolism and fetal ‘programming’ of adult pathophysiology. Nat Clin Pract Endocrinol Metab 3:479–488CrossRefPubMed
27.
go back to reference Dötsch J (2009) Renal and extrarenal mechanisms of perinatal programming after intrauterine growth restriction. Hypertens Res 32:238–241CrossRefPubMed Dötsch J (2009) Renal and extrarenal mechanisms of perinatal programming after intrauterine growth restriction. Hypertens Res 32:238–241CrossRefPubMed
28.
go back to reference Steinert JR, Wyatt AW, Poston L, Jacob R, Mann GE (2002) Preeclampsia is associated with altered Ca2+ regulation and nitric oxide production in human fetal venous endothelial cells. FASEB J 16:721–723PubMed Steinert JR, Wyatt AW, Poston L, Jacob R, Mann GE (2002) Preeclampsia is associated with altered Ca2+ regulation and nitric oxide production in human fetal venous endothelial cells. FASEB J 16:721–723PubMed
29.
go back to reference Falkner B, DeLoach S (2009) Refining the blood pressure phenotype in children: When does target organ damage begin? Hypertension 53:905–906CrossRefPubMed Falkner B, DeLoach S (2009) Refining the blood pressure phenotype in children: When does target organ damage begin? Hypertension 53:905–906CrossRefPubMed
30.
go back to reference Lurbe E, Cifkova R, Cruickshank JK, Dillon MJ, Ferreira I, Invitti C, Kuznetsova T, Laurent S, Mancia G, Morales-Olivas F, Rascher W, Redon J, Schaefer F, Seeman T, Stergiou G, Wühl E, Zanchetti A (2009) Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension. J Hypertens 27:1719–1742CrossRefPubMed Lurbe E, Cifkova R, Cruickshank JK, Dillon MJ, Ferreira I, Invitti C, Kuznetsova T, Laurent S, Mancia G, Morales-Olivas F, Rascher W, Redon J, Schaefer F, Seeman T, Stergiou G, Wühl E, Zanchetti A (2009) Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension. J Hypertens 27:1719–1742CrossRefPubMed
Metadata
Title
Early vascular phenotypes in the genesis of hypertension
Authors
Empar Lurbe
Maria Isabel Torró
Publication date
01-04-2010
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 4/2010
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-009-1357-9

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