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01-05-2018 | Original Paper

Early vagal nerve stimulator implantation in children: personal experience and review of the literature

Authors: Jehuda Soleman, Corine Knorr, Alexandre N. Datta, Susi Strozzi, Gian Paolo Ramelli, Luigi Mariani, Raphael Guzman

Published in: Child's Nervous System | Issue 5/2018

Abstract

Aim

Data concerning the benefit of vagal nerve stimulation (VNS) in children under the age of 12 years is sparse. It was shown that reduction of seizure frequency and duration at an early age could lead to better psychomotor development. We therefore compare the outcome between early (≤ 5 years of age) and late (> 5 years of age) implantation of VNS in children.

Methods

This study is a prospective review of patients analyzing primarily the reduction of seizure frequency and secondarily epilepsy outcome assessed by the McHugh and Engel classification, reduction of antiepileptic drugs (AED), psychomotor development measured by the Vineland Adaptive Behavior Scale (VABS), and quality of life using the caregiver impression (CGI) scale. Mean follow-up time was 36 and 31 months in the early and late group, respectively.

Results

Out of 12 consecutive VNS implantations for therapy refractory epilepsy, 5 were early implantations and 7 late implantations. Reduction of seizure frequency, McHugh and Engel classification, quality of life, psychomotor development and reduction of AED were comparable in both groups. One patient in the late group suffered from a postoperative infection resulting in explanation of the VNS device and re-implantation on the opposite side, while mortality rate was 0%.

Conclusions

VNS seems to be a safe and feasible therapy in children even under the age of 5 years. Responder rate, quality of life, and psychomotor development do not seem to be influenced by the child’s age at implantation; however, larger studies analyzing the outcome of early VNS implantation are warranted.

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Title: Early vagal nerve stimulator implantation in children: personal experience and review of the literature
Authors: Jehuda Soleman
Corine Knorr
Alexandre N. Datta
Susi Strozzi
Gian Paolo Ramelli
Luigi Mariani
Raphael Guzman
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 5/2018
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-017-3694-5

At a glance: The STEP trials

Springer Medicine

Early vagal nerve stimulator implantation in children: personal experience and review of the literature

Abstract

Aim

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Aim

Methods

Results

Conclusions

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