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Open Access 01-07-2011 | Neuro

Early postoperative MRI overestimates residual tumour after resection of gliomas with no or minimal enhancement

Authors: Sinan M. K. Belhawi, Friso W. A. Hoefnagels, Johannes C. Baaijen, Esther Sanchez Aliaga, Jaap C. Reijneveld, Jan J. Heimans, Frederik Barkhof, W. Peter Vandertop, Philip C. De Witt Hamer

Published in: European Radiology | Issue 7/2011

Abstract

Background

Standards for residual tumour measurement after resection of gliomas with no or minimal enhancement have not yet been established. In this study residual volumes on early and late postoperative T2-/FLAIR-weighted MRI are compared.

Methods

A retrospective cohort included 58 consecutive glioma patients with no or minimal preoperative gadolinium enhancement. Inclusion criteria were first-time resection between 2007 and 2009 with a T2-/FLAIR-based target volume and availability of preoperative, early (<48 h) and late (1–7 months) postoperative MRI. The volumes of non-enhancing T2/FLAIR tissue and diffusion restriction areas were measured.

Results

Residual tumour volumes were 22% smaller on late postoperative compared with early postoperative T2-weighted MRI and 49% smaller for FLAIR-weighted imaging. Postoperative restricted diffusion volume correlated with the difference between early and late postoperative FLAIR volumes and with the difference between T2 and FLAIR volumes on early postoperative MRI.

Conclusion

We observed a systematic and substantial overestimation of residual non-enhancing volume on MRI within 48 h of resection compared with months postoperatively, in particular for FLAIR imaging. Resection-induced ischaemia contributes to this overestimation, as may other operative effects. This indicates that early postoperative MRI is less reliable to determine the extent of non-enhancing residual glioma and restricted diffusion volumes are imperative.

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Title: Early postoperative MRI overestimates residual tumour after resection of gliomas with no or minimal enhancement
Authors: Sinan M. K. Belhawi
Friso W. A. Hoefnagels
Johannes C. Baaijen
Esther Sanchez Aliaga
Jaap C. Reijneveld
Jan J. Heimans
Frederik Barkhof
W. Peter Vandertop
Philip C. De Witt Hamer
Publication date: 01-07-2011
Publisher: Springer-Verlag
Published in: European Radiology / Issue 7/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2081-y

2024 ASCO Annual Meeting

Springer Medicine

Early postoperative MRI overestimates residual tumour after resection of gliomas with no or minimal enhancement

Abstract

Background

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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