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Critical Care
Published in: Critical Care 6/2004

Open Access 01-12-2004 | Research

Early postoperative hyperglycaemia is not a risk factor for infectious complications and prolonged in-hospital stay in patients undergoing oesophagectomy: a retrospective analysis of a prospective trial

Authors: Titia M Vriesendorp, JHans DeVries, Jan BF Hulscher, Frits Holleman, Jan J van Lanschot, Joost BL Hoekstra

Published in: Critical Care | Issue 6/2004

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Abstract

Introduction

Treating hyperglycaemia in hospitalized patients has proven to be beneficial, particularly in those with obstructive vascular disease. In a cohort of patients undergoing resection for oesophageal carcinoma (a group of patients with severe surgical stress but a low prevalence of vascular disease), we investigated whether early postoperative hyperglycaemia is associated with increased incidence of infectious complications and prolonged in-hospital stay.

Methods

Postoperative glucose values up to 48 hours after surgery were retrieved for 151 patients with American Society of Anesthesiologists class I or II who had been previously included in a randomized trial conducted in a tertiary referral hospital. Multivariate regression analysis was used to define the independent contribution of possible risk factors selected by univariate analysis.

Results

In univariate regression analysis, postoperative glucose levels were associated with increased length of in-hospital stay (P < 0.001) but not with infectious complications (P = 0.21). However, postoperative glucose concentration was not found to be an independent risk factor for prolonged in-hospital stay in multivariate analysis (P = 0.20).

Conclusion

Our data indicate that postoperative hyperglycaemia is more likely to be a risk marker than a risk factor in patients undergoing highly invasive surgery for oesophageal cancer. We hypothesize that patients with a low prevalence of vascular disease may benefit less from intensive insulin therapy.
Appendix
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Metadata
Title
Early postoperative hyperglycaemia is not a risk factor for infectious complications and prolonged in-hospital stay in patients undergoing oesophagectomy: a retrospective analysis of a prospective trial
Authors
Titia M Vriesendorp
JHans DeVries
Jan BF Hulscher
Frits Holleman
Jan J van Lanschot
Joost BL Hoekstra
Publication date
01-12-2004
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2004
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2970

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