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Published in: Knee Surgery, Sports Traumatology, Arthroscopy 6/2016

01-06-2016 | Knee

Early osteoarthritis of the knee

Authors: Henning Madry, Elizaveta Kon, Vincenzo Condello, Giuseppe M. Peretti, Matthias Steinwachs, Romain Seil, Massimo Berruto, Lars Engebretsen, Giuseppe Filardo, Peter Angele

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 6/2016

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Abstract

There is an increasing awareness on the importance in identifying early phases of the degenerative processes in knee osteoarthritis (OA), the crucial period of the disease when there might still be the possibility to initiate treatments preventing its progression. Early OA may show a diffuse and ill-defined involvement, but also originate in the cartilage surrounding a focal lesion, thus necessitating a separate assessment of these two entities. Early OA can be considered to include a maximal involvement of 50 % of the cartilage thickness based on the macroscopic ICRS classification, reflecting an OARSI grade 4. The purpose of this paper was to provide an updated review of the current status of the diagnosis and definition of early knee OA, including the clinical, radiographical, histological, MRI, and arthroscopic definitions and biomarkers. Based on current evidence, practical classification criteria are presented. As new insights and technologies become available, they will further evolve to better define and treat early knee OA.
Level of evidence IV.
Literature
1.
go back to reference Adams ME, Brandt KD (1991) Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection. J Rheumatol 18(3):428–435PubMed Adams ME, Brandt KD (1991) Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection. J Rheumatol 18(3):428–435PubMed
2.
go back to reference Arendt EA, Dahm DL, Dejour D, Fithian DC (2014) Patellofemoral joint: from instability to arthritis. Instr Course Lect 63:355–368PubMed Arendt EA, Dahm DL, Dejour D, Fithian DC (2014) Patellofemoral joint: from instability to arthritis. Instr Course Lect 63:355–368PubMed
3.
go back to reference Baert IA, Jonkers I, Staes F, Luyten FP, Truijen S, Verschueren SM (2012) Gait characteristics and lower limb muscle strength in women with early and established knee osteoarthritis. Clin Biomech (Bristol, Avon) 28(1):40–47CrossRef Baert IA, Jonkers I, Staes F, Luyten FP, Truijen S, Verschueren SM (2012) Gait characteristics and lower limb muscle strength in women with early and established knee osteoarthritis. Clin Biomech (Bristol, Avon) 28(1):40–47CrossRef
4.
go back to reference Batsis JA, Germain CM, Vasquez E, Zbehlik AJ, Bartels SJ (2015) Physical activity predicts higher physical function in older adults: the osteoarthritis initiative. J Phys Act Health. doi:10.1123/jpah.2014-0531 PubMed Batsis JA, Germain CM, Vasquez E, Zbehlik AJ, Bartels SJ (2015) Physical activity predicts higher physical function in older adults: the osteoarthritis initiative. J Phys Act Health. doi:10.​1123/​jpah.​2014-0531 PubMed
5.
go back to reference Bauer DC, Hunter DJ, Abramson SB, Attur M, Corr M, Felson D, Heinegard D, Jordan JM, Kepler TB, Lane NE, Saxne T, Tyree B, Kraus VB (2006) Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthr Cartil 14(8):723–727CrossRefPubMed Bauer DC, Hunter DJ, Abramson SB, Attur M, Corr M, Felson D, Heinegard D, Jordan JM, Kepler TB, Lane NE, Saxne T, Tyree B, Kraus VB (2006) Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthr Cartil 14(8):723–727CrossRefPubMed
6.
go back to reference Bijlsma JW, Berenbaum F, Lafeber FP (2011) Osteoarthritis: an update with relevance for clinical practice. Lancet 377(9783):2115–2126CrossRefPubMed Bijlsma JW, Berenbaum F, Lafeber FP (2011) Osteoarthritis: an update with relevance for clinical practice. Lancet 377(9783):2115–2126CrossRefPubMed
7.
go back to reference Blanco FJ (2014) Osteoarthritis year in review 2014: we need more biochemical biomarkers in qualification phase. Osteoarthr Cartil 22(12):2025–2032CrossRefPubMed Blanco FJ (2014) Osteoarthritis year in review 2014: we need more biochemical biomarkers in qualification phase. Osteoarthr Cartil 22(12):2025–2032CrossRefPubMed
8.
go back to reference Brandt KD, Fife RS, Braunstein EM, Katz B (1991) Radiographic grading of the severity of knee osteoarthritis: relation of the Kellgren and Lawrence grade to a grade based on joint space narrowing, and correlation with arthroscopic evidence of articular cartilage degeneration. Arthritis Rheum 34(11):1381–1386CrossRefPubMed Brandt KD, Fife RS, Braunstein EM, Katz B (1991) Radiographic grading of the severity of knee osteoarthritis: relation of the Kellgren and Lawrence grade to a grade based on joint space narrowing, and correlation with arthroscopic evidence of articular cartilage degeneration. Arthritis Rheum 34(11):1381–1386CrossRefPubMed
9.
go back to reference Brouwer GM, van Tol AW, Bergink AP, Belo JN, Bernsen RM, Reijman M, Pols HA, Bierma-Zeinstra SM (2007) Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee. Arthritis Rheum 56(4):1204–1211CrossRefPubMed Brouwer GM, van Tol AW, Bergink AP, Belo JN, Bernsen RM, Reijman M, Pols HA, Bierma-Zeinstra SM (2007) Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee. Arthritis Rheum 56(4):1204–1211CrossRefPubMed
10.
go back to reference Case R, Thomas E, Clarke E, Peat G (2015) Prodromal symptoms in knee osteoarthritis: a nested case-control study using data from the osteoarthritis initiative. Osteoarthr Cartil 23(7):1083–1089CrossRefPubMedPubMedCentral Case R, Thomas E, Clarke E, Peat G (2015) Prodromal symptoms in knee osteoarthritis: a nested case-control study using data from the osteoarthritis initiative. Osteoarthr Cartil 23(7):1083–1089CrossRefPubMedPubMedCentral
11.
go back to reference Chan WP, Huang GS, Hsu SM, Chang YC, Ho WP (2008) Radiographic joint space narrowing in osteoarthritis of the knee: relationship to meniscal tears and duration of pain. Skelet Radiol 37(10):917–922CrossRef Chan WP, Huang GS, Hsu SM, Chang YC, Ho WP (2008) Radiographic joint space narrowing in osteoarthritis of the knee: relationship to meniscal tears and duration of pain. Skelet Radiol 37(10):917–922CrossRef
12.
go back to reference Chiba K, Ito M, Osaki M, Uetani M, Shindo H (2011) In vivo structural analysis of subchondral trabecular bone in osteoarthritis of the hip using multi-detector row CT. Osteoarthr Cartil 19(2):180–185CrossRefPubMed Chiba K, Ito M, Osaki M, Uetani M, Shindo H (2011) In vivo structural analysis of subchondral trabecular bone in osteoarthritis of the hip using multi-detector row CT. Osteoarthr Cartil 19(2):180–185CrossRefPubMed
13.
go back to reference Crawford DC, Safran MR (2006) Osteochondritis dissecans of the knee. J Am Acad Orthop Surg 14(2):90–100CrossRefPubMed Crawford DC, Safran MR (2006) Osteochondritis dissecans of the knee. J Am Acad Orthop Surg 14(2):90–100CrossRefPubMed
14.
go back to reference Culvenor AG, Collins NJ, Guermazi A, Cook JL, Vicenzino B, Khan KM, Beck N, van Leeuwen J, Crossley KM (2015) Early knee osteoarthritis is evident one year following anterior cruciate ligament reconstruction: a magnetic resonance imaging evaluation. Arthritis Rheumatol 67(4):946–955CrossRefPubMed Culvenor AG, Collins NJ, Guermazi A, Cook JL, Vicenzino B, Khan KM, Beck N, van Leeuwen J, Crossley KM (2015) Early knee osteoarthritis is evident one year following anterior cruciate ligament reconstruction: a magnetic resonance imaging evaluation. Arthritis Rheumatol 67(4):946–955CrossRefPubMed
15.
go back to reference Desrochers J, Amrein MW, Matyas JR (2013) Microscale surface friction of articular cartilage in early osteoarthritis. J Mech Behav Biomed Mater 25:11–22CrossRefPubMed Desrochers J, Amrein MW, Matyas JR (2013) Microscale surface friction of articular cartilage in early osteoarthritis. J Mech Behav Biomed Mater 25:11–22CrossRefPubMed
16.
go back to reference Dieppe P, Cushnaghan J, Young P, Kirwan J (1993) Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann Rheum Dis 52(8):557–563CrossRefPubMedPubMedCentral Dieppe P, Cushnaghan J, Young P, Kirwan J (1993) Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann Rheum Dis 52(8):557–563CrossRefPubMedPubMedCentral
17.
go back to reference Felson DT, Hodgson R (2014) Identifying and treating preclinical and early osteoarthritis. Rheum Dis Clin N Am 40(4):699–710CrossRef Felson DT, Hodgson R (2014) Identifying and treating preclinical and early osteoarthritis. Rheum Dis Clin N Am 40(4):699–710CrossRef
18.
go back to reference Felson DT, Nevitt MC, Yang M, Clancy M, Niu J, Torner JC, Lewis CE, Aliabadi P, Sack B, McCulloch C, Zhang Y (2008) A new approach yields high rates of radiographic progression in knee osteoarthritis. J Rheumatol 35(10):2047–2054PubMedPubMedCentral Felson DT, Nevitt MC, Yang M, Clancy M, Niu J, Torner JC, Lewis CE, Aliabadi P, Sack B, McCulloch C, Zhang Y (2008) A new approach yields high rates of radiographic progression in knee osteoarthritis. J Rheumatol 35(10):2047–2054PubMedPubMedCentral
19.
go back to reference Felson DT, Niu J, Guermazi A, Sack B, Aliabadi P (2011) Defining radiographic incidence and progression of knee osteoarthritis: suggested modifications of the Kellgren and Lawrence scale. Ann Rheum Dis 70(11):1884–1886CrossRefPubMedPubMedCentral Felson DT, Niu J, Guermazi A, Sack B, Aliabadi P (2011) Defining radiographic incidence and progression of knee osteoarthritis: suggested modifications of the Kellgren and Lawrence scale. Ann Rheum Dis 70(11):1884–1886CrossRefPubMedPubMedCentral
20.
go back to reference Fingleton C, Smart K, Moloney N, Fullen BM, Doody C (2015) Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthr Cartil 23(7):1043–1056CrossRefPubMed Fingleton C, Smart K, Moloney N, Fullen BM, Doody C (2015) Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthr Cartil 23(7):1043–1056CrossRefPubMed
21.
go back to reference Funck-Brentano T, Cohen-Solal M (2011) Crosstalk between cartilage and bone: when bone cytokines matter. Cytokine Growth Factor Rev 22(2):91–97CrossRefPubMed Funck-Brentano T, Cohen-Solal M (2011) Crosstalk between cartilage and bone: when bone cytokines matter. Cytokine Growth Factor Rev 22(2):91–97CrossRefPubMed
22.
go back to reference Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, Carr AJ (2015) Osteoarthritis. Lancet 386(9991):376–387CrossRefPubMed Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, Carr AJ (2015) Osteoarthritis. Lancet 386(9991):376–387CrossRefPubMed
23.
go back to reference Goldring MB, Berenbaum F (2015) Emerging targets in osteoarthritis therapy. Curr Opin Pharmacol 22:51–63CrossRefPubMed Goldring MB, Berenbaum F (2015) Emerging targets in osteoarthritis therapy. Curr Opin Pharmacol 22:51–63CrossRefPubMed
25.
go back to reference Hensor EM, Dube B, Kingsbury SR, Tennant A, Conaghan PG (2014) Toward a clinical definition of early osteoarthritis: onset of patient-reported knee pain begins on stairs. Data from the osteoarthritis initiative. Arthritis Care Res (Hoboken) 67(1):40–47CrossRef Hensor EM, Dube B, Kingsbury SR, Tennant A, Conaghan PG (2014) Toward a clinical definition of early osteoarthritis: onset of patient-reported knee pain begins on stairs. Data from the osteoarthritis initiative. Arthritis Care Res (Hoboken) 67(1):40–47CrossRef
26.
go back to reference Hutton CW, Higgs ER, Jackson PC, Watt I, Dieppe PA (1986) 99mTc HMDP bone scanning in generalised nodal osteoarthritis. I. Comparison of the standard radiograph and four hour bone scan image of the hand. Ann Rheum Dis 45(8):617–621CrossRefPubMedPubMedCentral Hutton CW, Higgs ER, Jackson PC, Watt I, Dieppe PA (1986) 99mTc HMDP bone scanning in generalised nodal osteoarthritis. I. Comparison of the standard radiograph and four hour bone scan image of the hand. Ann Rheum Dis 45(8):617–621CrossRefPubMedPubMedCentral
27.
go back to reference Jones LD, Bottomley N, Harris K, Jackson W, Price AJ, Beard DJ (2014) The clinical symptom profile of early radiographic knee arthritis: a pain and function comparison with advanced disease. Knee Surg Sports Traumatol Arthrosc 24(1):161–168CrossRefPubMed Jones LD, Bottomley N, Harris K, Jackson W, Price AJ, Beard DJ (2014) The clinical symptom profile of early radiographic knee arthritis: a pain and function comparison with advanced disease. Knee Surg Sports Traumatol Arthrosc 24(1):161–168CrossRefPubMed
28.
go back to reference Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H (2010) Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 7(1):33–42CrossRefPubMed Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H (2010) Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 7(1):33–42CrossRefPubMed
29.
go back to reference Karlsen TA, Jakobsen RB, Mikkelsen TS, Brinchmann JE (2013) microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN. Stem Cells Dev 23(3):290–304CrossRefPubMed Karlsen TA, Jakobsen RB, Mikkelsen TS, Brinchmann JE (2013) microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN. Stem Cells Dev 23(3):290–304CrossRefPubMed
31.
go back to reference Kraus VB, Feng S, Wang S, White S, Ainslie M, Graverand MP, Brett A, Eckstein F, Hunter DJ, Lane NE, Taljanovic MS, Schnitzer T, Charles HC (2013) Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression. Arthritis Rheum 65(7):1812–1821CrossRefPubMedPubMedCentral Kraus VB, Feng S, Wang S, White S, Ainslie M, Graverand MP, Brett A, Eckstein F, Hunter DJ, Lane NE, Taljanovic MS, Schnitzer T, Charles HC (2013) Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression. Arthritis Rheum 65(7):1812–1821CrossRefPubMedPubMedCentral
32.
go back to reference Li B, Aspden RM (1997) Mechanical and material properties of the subchondral bone plate from the femoral head of patients with osteoarthritis or osteoporosis. Ann Rheum Dis 56(4):247–254CrossRefPubMedPubMedCentral Li B, Aspden RM (1997) Mechanical and material properties of the subchondral bone plate from the femoral head of patients with osteoarthritis or osteoporosis. Ann Rheum Dis 56(4):247–254CrossRefPubMedPubMedCentral
33.
go back to reference Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyere O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY (2014) Republished: value of biomarkers in osteoarthritis: current status and perspectives. Postgrad Med J 90(1061):171–178CrossRefPubMedPubMedCentral Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyere O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY (2014) Republished: value of biomarkers in osteoarthritis: current status and perspectives. Postgrad Med J 90(1061):171–178CrossRefPubMedPubMedCentral
34.
go back to reference Luyten FP, Denti M, Filardo G, Kon E, Engebretsen L (2011) Definition and classification of early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc 20(3):401–406CrossRefPubMed Luyten FP, Denti M, Filardo G, Kon E, Engebretsen L (2011) Definition and classification of early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc 20(3):401–406CrossRefPubMed
35.
go back to reference Madry H, Luyten FP, Facchini A (2012) Biological aspects of early osteoarthritis. Knee Surg Sports Traumatol Arthrosc 30(3):407–422CrossRef Madry H, Luyten FP, Facchini A (2012) Biological aspects of early osteoarthritis. Knee Surg Sports Traumatol Arthrosc 30(3):407–422CrossRef
36.
go back to reference Muraki S, Akune T, En-Yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Tanaka S, Nakamura K, Kawaguchi H, Oka H, Yoshimura N (2015) Joint space narrowing, body mass index, and knee pain: the ROAD study (OAC1839R1). Osteoarthr Cartil 23(6):874–881CrossRefPubMed Muraki S, Akune T, En-Yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Tanaka S, Nakamura K, Kawaguchi H, Oka H, Yoshimura N (2015) Joint space narrowing, body mass index, and knee pain: the ROAD study (OAC1839R1). Osteoarthr Cartil 23(6):874–881CrossRefPubMed
37.
go back to reference Neogi T, Bowes MA, Niu J, De Souza KM, Vincent GR, Goggins J, Zhang Y, Felson DT (2013) Magnetic resonance imaging-based three-dimensional bone shape of the knee predicts onset of knee osteoarthritis: data from the osteoarthritis initiative. Arthritis Rheum 65(8):2048–2058CrossRefPubMedPubMedCentral Neogi T, Bowes MA, Niu J, De Souza KM, Vincent GR, Goggins J, Zhang Y, Felson DT (2013) Magnetic resonance imaging-based three-dimensional bone shape of the knee predicts onset of knee osteoarthritis: data from the osteoarthritis initiative. Arthritis Rheum 65(8):2048–2058CrossRefPubMedPubMedCentral
38.
go back to reference Neu CP, Reddi AH, Komvopoulos K, Schmid TM, Di Cesare PE (2010) Increased friction coefficient and superficial zone protein expression in patients with advanced osteoarthritis. Arthritis Rheum 62(9):2680–2687CrossRefPubMedPubMedCentral Neu CP, Reddi AH, Komvopoulos K, Schmid TM, Di Cesare PE (2010) Increased friction coefficient and superficial zone protein expression in patients with advanced osteoarthritis. Arthritis Rheum 62(9):2680–2687CrossRefPubMedPubMedCentral
39.
go back to reference Niemeyer P, Andereya S, Angele P, Ateschrang A, Aurich M, Baumann M, Behrens P, Bosch U, Erggelet C, Fickert S, Fritz J, Gebhard H, Gelse K, Gunther D, Hoburg A, Kasten P, Kolombe T, Madry H, Marlovits S, Meenen NM, Muller PE, Noth U, Petersen JP, Pietschmann M, Richter W, Rolauffs B, Rhunau K, Schewe B, Steinert A, Steinwachs MR, Welsch GH, Zinser W, Albrecht D (2013) Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: a guideline by the working group “Tissue Regeneration” of the German Society of Orthopaedic Surgery and Traumatology (DGOU). Z Orthop Unfall 151(1):38–47PubMed Niemeyer P, Andereya S, Angele P, Ateschrang A, Aurich M, Baumann M, Behrens P, Bosch U, Erggelet C, Fickert S, Fritz J, Gebhard H, Gelse K, Gunther D, Hoburg A, Kasten P, Kolombe T, Madry H, Marlovits S, Meenen NM, Muller PE, Noth U, Petersen JP, Pietschmann M, Richter W, Rolauffs B, Rhunau K, Schewe B, Steinert A, Steinwachs MR, Welsch GH, Zinser W, Albrecht D (2013) Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: a guideline by the working group “Tissue Regeneration” of the German Society of Orthopaedic Surgery and Traumatology (DGOU). Z Orthop Unfall 151(1):38–47PubMed
40.
go back to reference Oka H, Muraki S, Akune T, Mabuchi A, Suzuki T, Yoshida H, Yamamoto S, Nakamura K, Yoshimura N, Kawaguchi H (2008) Fully automatic quantification of knee osteoarthritis severity on plain radiographs. Osteoarthr Cartil 16(11):1300–1306CrossRefPubMed Oka H, Muraki S, Akune T, Mabuchi A, Suzuki T, Yoshida H, Yamamoto S, Nakamura K, Yoshimura N, Kawaguchi H (2008) Fully automatic quantification of knee osteoarthritis severity on plain radiographs. Osteoarthr Cartil 16(11):1300–1306CrossRefPubMed
41.
go back to reference Orth P, Cucchiarini M, Wagenpfeil S, Menger MD, Madry H (2014) PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis. Osteoarthr Cartil 22(6):813–821CrossRefPubMed Orth P, Cucchiarini M, Wagenpfeil S, Menger MD, Madry H (2014) PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis. Osteoarthr Cartil 22(6):813–821CrossRefPubMed
42.
go back to reference Palmer AJ, Brown CP, McNally EG, Price AJ, Tracey I, Jezzard P, Carr AJ, Glyn-Jones S (2013) Non-invasive imaging of cartilage in early osteoarthritis. Bone Joint J 95(6):738–746CrossRefPubMed Palmer AJ, Brown CP, McNally EG, Price AJ, Tracey I, Jezzard P, Carr AJ, Glyn-Jones S (2013) Non-invasive imaging of cartilage in early osteoarthritis. Bone Joint J 95(6):738–746CrossRefPubMed
43.
go back to reference Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D, van den Berg WB (2006) Osteoarthritis cartilage histopathology: grading and staging. Osteoarthr Cartil 14(1):13–29CrossRefPubMed Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D, van den Berg WB (2006) Osteoarthritis cartilage histopathology: grading and staging. Osteoarthr Cartil 14(1):13–29CrossRefPubMed
44.
go back to reference Radin EL, Paul IL, Tolkoff MJ (1970) Subchondral bone changes in patients with early degenerative joint disease. Arthritis Rheum 13(4):400–405CrossRefPubMed Radin EL, Paul IL, Tolkoff MJ (1970) Subchondral bone changes in patients with early degenerative joint disease. Arthritis Rheum 13(4):400–405CrossRefPubMed
45.
go back to reference Reijman M, Pols HA, Bergink AP, Hazes JM, Belo JN, Lievense AM, Bierma-Zeinstra SM (2007) Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis 66(2):158–162CrossRefPubMedPubMedCentral Reijman M, Pols HA, Bergink AP, Hazes JM, Belo JN, Lievense AM, Bierma-Zeinstra SM (2007) Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis 66(2):158–162CrossRefPubMedPubMedCentral
46.
go back to reference Ritter SY, Collins J, Krastins B, Sarracino D, Lopez M, Losina E, Aliprantis AO (2014) Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis. Arthritis Res Ther 16(5):456CrossRefPubMedPubMedCentral Ritter SY, Collins J, Krastins B, Sarracino D, Lopez M, Losina E, Aliprantis AO (2014) Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis. Arthritis Res Ther 16(5):456CrossRefPubMedPubMedCentral
47.
go back to reference Ryd L, Brittberg M, Eriksson K, Jurvelin JS, Lindahl A, Marlovits S, Moller P, Richardson JB, Steinwachs M, Zenobi-Wong M (2015) Pre-osteoarthritis: definition and diagnosis of an elusive clinical entity. Cartilage 6(3):156–165CrossRefPubMed Ryd L, Brittberg M, Eriksson K, Jurvelin JS, Lindahl A, Marlovits S, Moller P, Richardson JB, Steinwachs M, Zenobi-Wong M (2015) Pre-osteoarthritis: definition and diagnosis of an elusive clinical entity. Cartilage 6(3):156–165CrossRefPubMed
48.
go back to reference Saberi Hosnijeh F, Runhaar J, van Meurs JB, Bierma-Zeinstra SM (2015) Biomarkers for osteoarthritis: can they be used for risk assessment? A systematic review. Maturitas 82(1):36–49CrossRef Saberi Hosnijeh F, Runhaar J, van Meurs JB, Bierma-Zeinstra SM (2015) Biomarkers for osteoarthritis: can they be used for risk assessment? A systematic review. Maturitas 82(1):36–49CrossRef
49.
go back to reference Sakata R, McNary SM, Miyatake K, Lee CA, Van den Bogaerde JM, Marder RA, Reddi AH (2015) Stimulation of the superficial zone protein and lubrication in the articular cartilage by human platelet-rich plasma. Am J Sports Med 43(6):1467–1473CrossRefPubMed Sakata R, McNary SM, Miyatake K, Lee CA, Van den Bogaerde JM, Marder RA, Reddi AH (2015) Stimulation of the superficial zone protein and lubrication in the articular cartilage by human platelet-rich plasma. Am J Sports Med 43(6):1467–1473CrossRefPubMed
50.
go back to reference Saris DB, Dhert WJ, Verbout AJ (2003) Joint homeostasis. The discrepancy between old and fresh defects in cartilage repair. J Bone Joint Surg Br 85(7):1067–1076CrossRefPubMed Saris DB, Dhert WJ, Verbout AJ (2003) Joint homeostasis. The discrepancy between old and fresh defects in cartilage repair. J Bone Joint Surg Br 85(7):1067–1076CrossRefPubMed
52.
go back to reference Schinhan M, Gruber M, Vavken P, Dorotka R, Samouh L, Chiari C, Gruebl-Barabas R, Nehrer S (2012) Critical-size defect induces unicompartmental osteoarthritis in a stable ovine knee. J Orthop Res 30(2):214–220CrossRefPubMed Schinhan M, Gruber M, Vavken P, Dorotka R, Samouh L, Chiari C, Gruebl-Barabas R, Nehrer S (2012) Critical-size defect induces unicompartmental osteoarthritis in a stable ovine knee. J Orthop Res 30(2):214–220CrossRefPubMed
53.
54.
go back to reference Thorstensson CA, Andersson ML, Jonsson H, Saxne T, Petersson IF (2009) Natural course of knee osteoarthritis in middle-aged subjects with knee pain: 12-year follow-up using clinical and radiographic criteria. Ann Rheum Dis 68(12):1890–1893CrossRefPubMed Thorstensson CA, Andersson ML, Jonsson H, Saxne T, Petersson IF (2009) Natural course of knee osteoarthritis in middle-aged subjects with knee pain: 12-year follow-up using clinical and radiographic criteria. Ann Rheum Dis 68(12):1890–1893CrossRefPubMed
55.
go back to reference Tsezou A (2014) Osteoarthritis year in review 2014: genetics and genomics. Osteoarthr Cartil 22(12):2017–2024CrossRefPubMed Tsezou A (2014) Osteoarthritis year in review 2014: genetics and genomics. Osteoarthr Cartil 22(12):2017–2024CrossRefPubMed
56.
go back to reference Van Spil WE, Welsing PM, Bierma-Zeinstra SM, Bijlsma JW, Roorda LD, Cats HA, Lafeber FP (2015) The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK. Osteoarthr Cartil 23(8):1388–1397CrossRefPubMed Van Spil WE, Welsing PM, Bierma-Zeinstra SM, Bijlsma JW, Roorda LD, Cats HA, Lafeber FP (2015) The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK. Osteoarthr Cartil 23(8):1388–1397CrossRefPubMed
57.
go back to reference Vincent HK, Heywood K, Connelly J, Hurley RW (2012) Obesity and weight loss in the treatment and prevention of osteoarthritis. PM R 4(5 Suppl):S59–S67CrossRefPubMedPubMedCentral Vincent HK, Heywood K, Connelly J, Hurley RW (2012) Obesity and weight loss in the treatment and prevention of osteoarthritis. PM R 4(5 Suppl):S59–S67CrossRefPubMedPubMedCentral
58.
go back to reference Wada M, Imura S, Baba H, Shimada S (1996) Knee laxity in patients with osteoarthritis and rheumatoid arthritis. Br J Rheumatol 35(6):560–563CrossRefPubMed Wada M, Imura S, Baba H, Shimada S (1996) Knee laxity in patients with osteoarthritis and rheumatoid arthritis. Br J Rheumatol 35(6):560–563CrossRefPubMed
59.
go back to reference Xu L, Polur I, Servais JM, Hsieh S, Lee PL, Goldring MB, Li Y (2011) Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model. Am J Pathol 179(3):1338–1346CrossRefPubMedPubMedCentral Xu L, Polur I, Servais JM, Hsieh S, Lee PL, Goldring MB, Li Y (2011) Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model. Am J Pathol 179(3):1338–1346CrossRefPubMedPubMedCentral
60.
go back to reference Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, Boraska V, Esko T, Evangelou E, Hoffman A, Houwing-Duistermaat JJ, Ingvarsson T, Jonsdottir I, Jonnson H, Kerkhof HJ, Kloppenburg M, Bos SD, Mangino M, Metrustry S, Slagboom PE, Thorleifsson G, Raine EV, Ratnayake M, Ricketts M, Beazley C, Blackburn H, Bumpstead S, Elliott KS, Hunt SE, Potter SC, Shin SY, Yadav VK, Zhai G, Sherburn K, Dixon K, Arden E, Aslam N, Battley PK, Carluke I, Doherty S, Gordon A, Joseph J, Keen R, Koller NC, Mitchell S, O’Neill F, Paling E, Reed MR, Rivadeneira F, Swift D, Walker K, Watkins B, Wheeler M, Birrell F, Ioannidis JP, Meulenbelt I, Metspalu A, Rai A, Salter D, Stefansson K, Stykarsdottir U, Uitterlinden AG, van Meurs JB, Chapman K, Deloukas P, Ollier WE, Wallis GA, Arden N, Carr A, Doherty M, McCaskie A, Willkinson JM, Ralston SH, Valdes AM, Spector TD, Loughlin J (2012) Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 380(9844):815–823CrossRefPubMed Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, Boraska V, Esko T, Evangelou E, Hoffman A, Houwing-Duistermaat JJ, Ingvarsson T, Jonsdottir I, Jonnson H, Kerkhof HJ, Kloppenburg M, Bos SD, Mangino M, Metrustry S, Slagboom PE, Thorleifsson G, Raine EV, Ratnayake M, Ricketts M, Beazley C, Blackburn H, Bumpstead S, Elliott KS, Hunt SE, Potter SC, Shin SY, Yadav VK, Zhai G, Sherburn K, Dixon K, Arden E, Aslam N, Battley PK, Carluke I, Doherty S, Gordon A, Joseph J, Keen R, Koller NC, Mitchell S, O’Neill F, Paling E, Reed MR, Rivadeneira F, Swift D, Walker K, Watkins B, Wheeler M, Birrell F, Ioannidis JP, Meulenbelt I, Metspalu A, Rai A, Salter D, Stefansson K, Stykarsdottir U, Uitterlinden AG, van Meurs JB, Chapman K, Deloukas P, Ollier WE, Wallis GA, Arden N, Carr A, Doherty M, McCaskie A, Willkinson JM, Ralston SH, Valdes AM, Spector TD, Loughlin J (2012) Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 380(9844):815–823CrossRefPubMed
Metadata
Title
Early osteoarthritis of the knee
Authors
Henning Madry
Elizaveta Kon
Vincenzo Condello
Giuseppe M. Peretti
Matthias Steinwachs
Romain Seil
Massimo Berruto
Lars Engebretsen
Giuseppe Filardo
Peter Angele
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
Knee Surgery, Sports Traumatology, Arthroscopy / Issue 6/2016
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-016-4068-3

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