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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-05-2016 | Neurophthalmology

Early macular ganglion cell–inner plexiform layer analysis in non-arteritic anterior ischemic optic neuropathy

Authors: Sang Woo Park, Yong Sok Ji, Hwan Heo

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 5/2016

Abstract

Purpose

To investigate the potential usefulness of early macular ganglion cell–inner plexiform layer (mGCIPL) measurement for detecting retinal ganglion cell damage in eyes with non-arteritic anterior ischemic optic neuropathy (NAION).

Methods

Thirteen patients with NAION were examined within 1 month of visual disturbance onset and underwent spectral domain optical coherence tomography (SD-OCT) measurement of the mGCIPL and peripapillary retinal nerve fiber layer (pRNFL). Complete ophthalmologic evaluations, including visual acuity and visual field (VF) test, were performed. The time to minimum and average mGCIPL and pRNFL thinning were investigated. The correlation between the area of mGCIPL thinning and the affected VF area was also analyzed.

Results

Thirteen eyes of 13 patients with NAION were included. The length of time from visual disturbance onset to minimum and average mGCIPL thinning was 32.5 ± 12.1 days and 46.1 ± 23.2 days, respectively, and the time to pRNFL thinning was 79.2 ± 19.7 days. There was a significant regional correlation between the area of mGCIPL loss and that of the VF defect in the early phase (r = 0.610; p = 0.027). However, the area of mGCIPL thinning in the late phase did not correlate with that of late VF defects.

Conclusions

In the early phase, mGCIPL thinning was observed, and the area of mGCIPL thinning correlated with that of the VF defect in eyes with NAION. Therefore, early retinal ganglion cell damage and dysfunction may be detected in NAION by measurement of mGCIPL using SD-OCT.

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Title: Early macular ganglion cell–inner plexiform layer analysis in non-arteritic anterior ischemic optic neuropathy
Authors: Sang Woo Park
Yong Sok Ji
Hwan Heo
Publication date: 01-05-2016
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 5/2016
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-015-3230-9

At a glance: The STEP trials

Springer Medicine

Early macular ganglion cell–inner plexiform layer analysis in non-arteritic anterior ischemic optic neuropathy

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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