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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 11/2016

01-10-2016 | Gastrointestinal Oncology

Early Gastric Cancer: Trends in Incidence, Management, and Survival in a Well-Defined French Population

Authors: Nicolas Chapelle, MD, Anne-Marie Bouvier, MD, PhD, Sylvain Manfredi, MD, PhD, Antoine Drouillard, MD, Come Lepage, MD, PhD, Jean Faivre, MD, PhD, Valerie Jooste, PhD

Published in: Annals of Surgical Oncology | Issue 11/2016

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Abstract

Background

Little is known about the epidemiology of early gastric cancer (EGC) in Western countries. The aim of this study was to analyze trends in the incidence, management, and survival of EGC in a well-defined population over a 30 year period.

Methods

Data were obtained from the population-based cancer Registry of Burgundy (France). Incidence rates were calculated by sex, age, and 10 year period of diagnosis. Net survival rates were calculated and a multivariate relative survival analysis performed.

Results

EGC represented 6.7 % of gastric cancer diagnosed between 1982 and 2011. Age-standardized incidence rates were higher in men (0.79/100,000) than in women (0.40/100,000). Between the periods 1982–1991 and 2002–2011, it decreased from 0.97 to 0.53 per 100,000 in men and from 0.44 to 0.30 per 100,000 in women. Overall, 19 % of the tumors were limited to the mucosa, 69 % to the submucosa, and 15 % invaded lymph nodes. Node invasion and male sex were the only significant prognostic factors. Five-year net survival was 50 % in node-positive patients and 85 % in node-negative patients (p < 0.001). In multivariate analysis, the relative risk of death in men compared to women was 2.3 and was 10.4 in patients with positive nodes compared to patients with negative nodes.

Conclusions

EGCs are rare in France. The prognosis is favorable, except for node-positive cancers, which may benefit from the recently developed adjuvant chemotherapy for gastric cancer.
Literature
1.
Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–86.CrossRefPubMed
2.
Dassen AE, Dikken JL, Bosscha K, et al. Gastric cancer: decreasing incidence but stable survival in The Netherlands. Acta Oncol. 2014;53:138–42.CrossRefPubMed
3.
Herbreteau E, Jooste V, Hamza S, et al. Trends in the management of gastric cancer over a 32-year period: a French population-based study. Gastric Cancer. 2015;18:129–37.CrossRefPubMed
4.
Kikuchi S, Katada N, Sakuramoto S, et al. Survival after surgical treatment of early gastric cancer: surgical techniques and long-term survival. Langenbecks Arch Surg. 2004;389:69–74.CrossRefPubMed
5.
Murakani T. Pathomorphological diagnosis. Definition and gross classification of early gastric cancer. Gann Monogr Cancer Res. 1971:53–5.
6.
Sano T, Katai H, Sasako M, et al. The management of early gastric cancer. Surg Oncol. 2000;9:17–22.CrossRefPubMed
7.
Fukutomi H, Sakita T. Analysis of early gastric cancer cases collected from major hospitals and institutes in Japan. Jpn J Clin Oncol. 1984;14:169–79.PubMed
8.
9.
World Health Organization. International classification of disease for oncology. 3rd ed. Geneva: World Health Organization; 1993.
10.
11.
Nelson CP, Lambert PC, Squire IB, et al. Flexible parametric models for relative survival, with application in coronary heart disease. Stat Med. 2007;26:5486–98.CrossRefPubMed
12.
Chapelle N, Manfredi S, Lepage C, et al. Trends in gastric cancer incidence: a period and birth cohort analysis in a well-defined French population. Gastric Cancer. 2016;19:608–14.CrossRef
13.
Bollschweiler E, Boettcher K, Hoelscher AH, et al. Is the prognosis for Japanese and German patients with gastric cancer really different? Cancer. 1993;71:2918–25.CrossRefPubMed
14.
Faria GR, Pinto-de-Sousa J, Preto JR, et al. Three decades of clinical-pathological trends in gastric cancer: prospective data from a Portuguese hospital. Int J Surg. 2013;11:472–6.CrossRefPubMed
15.
Marrelli D, Pedrazzani C, Morgagni P, et al. Changing clinical and pathological features of gastric cancer over time. Br J Surg. 2011;98:1273–83.CrossRefPubMed
16.
Koga M, Ideda S, Iwasaki M. Report of gastric mass survey in 1997. J Gastroenterol Mass Surv. 2000;38:163–81.
17.
Hisamichi S, Sugawara N. Mass screening for gastric cancer by X-ray examination. Jpn J Clin Oncol. 1984;14:211–23.PubMed
18.
19.
Suvakovic Z, Bramble MG, Jones R, et al. Improving the detection rate of early gastric cancer requires more than open access gastroscopy: a five year study. Gut. 1997;41:308–13.CrossRefPubMedPubMedCentral
20.
Sakita T, Oguro Y, Takasu S, et al. Observations on the healing of ulcerations in early gastric cancer. Gastroenterology. 1971;60:835–44.PubMed
21.
Kwee RM, Kwee TC. Predicting lymph node status in early gastric cancer. Gastric Cancer. 2008;11:134–48.CrossRefPubMed
22.
Gotoda T, Yanagisawa A, Sasako M, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer. 2000;3:219–25.CrossRefPubMed
23.
Holscher AH, Drebber U, Monig SP, et al. Early gastric cancer: lymph node metastasis starts with deep mucosal infiltration. Ann Surg. 2009;250:791–7.CrossRefPubMed
24.
Saragoni L, Gaudio M, Morgagni P, et al. The role of growth patterns, according to Kodama’s classification, and lymph node status, as important prognostic factors in early gastric cancer: analysis of 412 cases. Gastric Cancer. 2000;3:134–40.CrossRefPubMed
25.
26.
Mitsumori N, Nimura H, Takahashi N, et al. Sentinel lymph node navigation surgery for early stage gastric cancer. World J Gastroenterol. 2014;20:5685–93.CrossRefPubMedPubMedCentral
27.
Moehler M, Al-Batran SE, Andus T, et al. German S3-guideline diagnosis and treatment of esophagogastric cancer. Z Gastroenterol. 2011;49:461–31.CrossRefPubMed
28.
Bouvier AM, Haas O, Piard F, et al. How many nodes must be examined to accurately stage gastric carcinomas? Results from a population based study. Cancer. 2002;94:2862–6.CrossRefPubMed
29.
Waddell T, Verheij M, Allum W, et al. Gastric cancer: ESMO-ESSO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24(suppl 6):vi57–63.CrossRefPubMed
30.
Sano T, Okuyama Y, Kobori O, et al. Early gastric cancer. Endoscopic diagnosis of depth of invasion. Dig Dis Sci. 1990;35:1340–4.CrossRefPubMed
31.
Kim YI, Kim YW, Choi IJ, et al. Long-term survival after endoscopic resection versus surgery in early gastric cancers. Endoscopy. 2015;47:293–301.CrossRefPubMed
32.
Park SY, Moon HS, Seong JK, et al. Successful treatment of a gastric plasmacytoma using a combination of endoscopic submucosal dissection and oral thalidomide. Clin Endosc. 2014;47:564–7.CrossRefPubMedPubMedCentral
33.
Ahn JY, Jung HY, Choi KD, et al. Endoscopic and oncologic outcomes after endoscopic resection for early gastric cancer: 1370 cases of absolute and extended indications. Gastrointest Endosc. 2011;74:485–93.CrossRefPubMed
34.
Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345:725–30.CrossRefPubMed
35.
Schlemper RJ, Itabashi M, Kato Y, et al. Differences in diagnostic criteria for gastric carcinoma between Japanese and western pathologists. Lancet. 1997;349:1725–9.CrossRefPubMed
36.
37.
Micheli A, Ciampichini R, Oberaigner W, et al. The advantage of women in cancer survival: an analysis of EUROCARE-4 data. Eur J Cancer. 2009;45:1017–27.CrossRefPubMed
38.
Qin J, Liu M, Ding Q, et al. The direct effect of estrogen on cell viability and apoptosis in human gastric cancer cells. Mol Cell Biochem. 2014;395:99–107.CrossRefPubMed
39.
Ryu WS, Kim JH, Jang YJ, et al. Expression of estrogen receptors in gastric cancer and their clinical significance. J Surg Oncol. 2012;106:456–61.CrossRefPubMed
Metadata
Title
Early Gastric Cancer: Trends in Incidence, Management, and Survival in a Well-Defined French Population
Authors
Nicolas Chapelle, MD
Anne-Marie Bouvier, MD, PhD
Sylvain Manfredi, MD, PhD
Antoine Drouillard, MD
Come Lepage, MD, PhD
Jean Faivre, MD, PhD
Valerie Jooste, PhD
Publication date
01-10-2016
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 11/2016
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-016-5279-z

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