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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 1/2016

01-07-2016 | Maternal-Fetal Medicine

Early fetal growth in progesterone-treated IVF pregnancies

Authors: D. Spiliopoulos, D. L. Economides

Published in: Archives of Gynecology and Obstetrics | Issue 1/2016

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Abstract

Purpose

The aim of this study was to compare fetal growth in the first and second trimesters of pregnancy and final birth weights between two groups of women: (a) spontaneous conceptions with reliable menstrual dates and (b) IVF pregnancies on progesterone supplementation during the first trimester.

Methods

We included in the study 73 singleton IVF pregnancies and 138 singleton spontaneous pregnancies. Exclusion criteria were: medications or presence of medical conditions affecting fetal growth. Fetal crown-rump length (CRL) at 10 + 1 to 13 + 6 weeks of gestation, and head circumference (HC), biparietal diameter (BPD), abdominal circumference (AC) and femur length (FL) at 18–24 weeks, were measured prospectively. The birth weights of the babies born were collected and compared. Independent sample t test was applied for comparing quantitative variables with normal distribution, and Wilcoxon–Mann–Whitney test was used for comparison of quantitative variables without normal distribution.

Results

IVF fetuses on progesterone supplementation had larger CRL measurements when compared to their counterparts from spontaneous pregnancies (p value = 0.045). Similarly, in the second trimester, the BPD was significantly larger but HC, AC and FL, although larger, did not reach statistical significance. The birthweights of babies between the two groups showed no statistically significant difference, although some IVF babies were born prematurely.

Conclusions

Enhanced fetal growth during the first trimester has been observed with progesterone supplementation in IVF pregnancies. Aspects of enhanced fetal growth were observed in the second trimester but not at birth. The effect of progesterone supplementation on fetal growth needs further investigation.
Literature
1.
Spencer TE, Burghardt RC, Johnson BA, Bazer FW (2004) Conceptus signals for establishment and maintenance of pregnancy. Anim Reprod Sci 82–83:537–550CrossRefPubMed
2.
Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF, Petraglia F (2009) Inflammation and pregnancy. Reprod Sci 16:206–215CrossRefPubMed
3.
4.
McCord ML, Muram D, Buster JE, Arheart KL, Stovall TG, Carson SA (1996) Single serum progesterone as a screen for ectopic pregnancy: exchanging specificity and sensitivity to obtain optimal test performance. Fertil Steril 66(4):513–516CrossRefPubMed
5.
Arck PC, Ruecke M, Rose M, Szekeres-Bartho J, Douglas AJ, Pritsch M, Blois SM, Pincus MK, Barenstrausch N, Dudenhausen JW (2008) Early risk factors for miscarriage: a prospective cohort study in pregnant women. Reprod Biomed Online 17:101–113CrossRefPubMed
6.
Wallace JM, Aitken RP, Cheyne MA, Humblot P (1997) Pregnancy-specific protein B and progesterone concentrations in relation to nutritional regimen, placental mass and pregnancy outcome in growing adolescent ewes carrying singleton fetuses. J Reprod Fertil 109(1):53–58CrossRefPubMed
7.
Nepomnaschy PA, Welch K, McConnell D, Strassmann BI, England BG (2004) Stress and female reproductive function: a study of daily variations in cortisol, gonadotrophins, and gonadal steroids in a rural Mayan population. Am J Hum Biol 16(5):523–532CrossRefPubMed
8.
Creel S, Winnie JA, Christianson D (2009) Glucocorticoid stress hormones and the effect of predation risk on elk reproduction. Proc Natl Acad Sci USA 106:12388–12393CrossRefPubMedPubMedCentral
9.
Ng SP, Steinetz BG, Lasano SG, Zelikoff JT (2006) Hormonal changes accompanying cigarette smoke-induced preterm births in a mouse model. Exp Biol Med 231:1403–1409
10.
Chedrese PJ, Feyles F (2001) The diverse mechanism of action of dichlorodiphenyldichloroethylene (DDE) and methoxychlor in ovarian cells in vitro. Reprod Toxicol 15:693–698CrossRefPubMed
11.
Campbell S, Thoms A (1977) Ultrasound measurement of fetal head to abdomen circumference ratio in the assessment of growth retardation. Br J Obstet Gynaecol 84:165–174CrossRefPubMed
12.
Campbell S, Wilkin D (1975) Ultrasonic measurement of fetal abdomen circumference in the estimation of fetal weight. Br J Obstet Gynaecol 82:689–697CrossRefPubMed
13.
Campbell S (1969) The prediction of fetal maturity by ultrasonic measurement of the biparietal diameter. J Obstet Gynaecol Br Commonw 76(7):603–609CrossRefPubMed
14.
Manalu W, Sumaryadi MY (1998) Maternal serum progesterone concentration during pregnancy and lamb birth weight at parturition in Javanese thin-tail ewes with different litter sizes. Small Ruminant Research 30:163–169CrossRef
15.
Mulholland J, Roy D, Glasser SR (1994) Progesterone directed gene expression in rat uterine stromal cells. In: Glasser SR, Mulholland J, Psychoyos A (eds) Endocrinology of embryo-endometrium interactions. Plenum press, New York, pp 33–39CrossRef
16.
17.
Gandolfi FT, Brevini AL, Modina S, Pasoni L (1992) Early embryonic signals: embryomaternal interactions before implantation. Anim Reprod Sci 28:176–269CrossRef
18.
Geisert RD, Short EC, Zavy MT (1992) Maternal recognition of pregnancy. Anim Reprod Sci 28:287–295CrossRef
19.
Kleemann DO, Walker SK, Seamark RF (1994) Enhanced fetal growth in sheep administered progesterone during the first three days of pregnancy. J Reprod Fertil 102(2):411–417CrossRefPubMed
20.
Haglund B (2007) Birthweight distributions by gestational age: comparison of LMP-based and ultrasound-based estimates of gestational age using data from the Swedish Birth Registry. Paediatr Perinat Epidemiol 21:72–78CrossRefPubMed
21.
Dietz PM, England LJ, Callaghan WM, Pearl M, Wier ML, Kharrazi M (2007) A comparison of LMP-based and ultrasound-based estimates of gestational age using linked California livebirth and prenatal screening records. Paediatr Perinat Epidemiol Suppl 2:62–71CrossRef
22.
Treolar A, Behn BG, Cowan DW (1967) Analysis of gestational interval. Am J Obstet Gynecol 99:34–45
23.
Papageorghiou AT, Ohuma EO, Altman DG, Todros T, Cheikh Ismail L, Lambert A, Jaffer YA, Bertino E, Gravett MG, Purwar M, Noble JA, Pang R, Victora CG, Barros FC, Carvalho M, Salomon LJ, Bhutta ZA, Kennedy SH, Villar J, International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) (2014) International standards for fetal growth based on serial ultrasound measurements: the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project. Lancet 384(9946):869–879
24.
Smith GC, Smith MF, McNay MB, Fleming JE (1998) First-trimester growth and the risk of low birth weight. N Engl J Med 339:1817–1822CrossRefPubMed
25.
Leung TY, Sahota DS, Chan LW, Law LW, Fung TY, Leung TN, Lau TK (2008) Prediction of birth weight by fetal crown-rump length and maternal serum levels of pregnancy-associated plasma protein-A in the first trimester. Ultrasound Obstet Gynecol 31(1):10–14CrossRefPubMed
26.
Mercer BM, Merlino AA, Milluzzi CJ, Moore JJ (2008) Small fetal size before 20 weeks’ gestation: associations with maternal tobacco use, early preterm birth, and low birthweight. Am J Obstet Gynecol 198(6): 673.e1–673.e7
27.
Thorsell M, Kaijser M, Almstrom H, Andolf E (2008) Expected day of delivery from ultrasound dating versus last menstrual period—obstetric outcome when dates mismatch. BJOG 115:585CrossRefPubMed
28.
Mook-Kanamori DO, Steegers EA, Eilers PH, Raat H, Hofman A, Jaddoe VW (2010) Risk factors and outcomes associated with first-trimester fetal growth restriction. JAMA 303(6):527–534CrossRefPubMed
29.
Jackson RA, Gibson KA, Wu YW, Croughan MS (2004) Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 103:551–563CrossRefPubMed
30.
Schieve LA, Cohen B, Nannini A, Ferre C, Reynolds MA, Zhang Z, Jeng G, Macaluso M, Wright VC (2007) A population-based study of maternal and perinatal outcomes associated with assisted reproductive technology in Massachusetts. Matern Child Health J 11:517–525CrossRefPubMed
31.
Ludwig M, Katalinic A, Gross S, Sutcliffe A, Varon R, Horsthemke B (2005) Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples. J Med Genet 42:289–291CrossRefPubMedPubMedCentral
32.
Sutcliffe AG, Peters CJ, Bowdin S, Temple K, Reardon W, Wilson L, Clayton-Smith J, Brueton LA, Bannister W, Maher ER (2006) Assisted reproductive therapies and imprinting disorders- a preliminary British survey. Hum Reprod 21:1009–1011CrossRefPubMed
33.
Hansen M, Kurinczuk JJ, Bower C, Webb S (2002) The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med 346:725–730CrossRefPubMed
34.
Ceelen M, van Weissenbruch MM, Roos JC, Vermeiden JP van Leeuwen FE, Delemarre-van de Waal HA (2007) Body composition in children and adolescents born after in vitro fertilization or spontaneous conception. J Clin Endocrinol Metab 92:3417–3423
35.
Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA (2008) Growth and development of children born after in vitro fertilization. Fertil Steril 90:1662–1673CrossRefPubMed
36.
Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA (2008) Pubertal development in children and adolescents born after IVF and spontaneous conception. Hum Reprod 23:2791–2798CrossRefPubMed
37.
Sazonova A, Kallen K, Thurin-Kjellberg A, Wennerholm UB, Bergh C (2012) Obstetric outcome in singletons after in vitro fertilisation with cryopreserved/thawed embryos. Hum Reprod 27(5):1343–1350CrossRefPubMed
38.
Wikland M, Hardarson T, Hillensjo T, Westin C, Westlander G, Wood M, Wennerholm UB (2010) Obstetric outcomes after transfer of vitrified blastocysts. Hum Reprod 25(7):1699–1707CrossRefPubMed
Metadata
Title
Early fetal growth in progesterone-treated IVF pregnancies
Authors
D. Spiliopoulos
D. L. Economides
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 1/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-015-3951-3

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