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01-12-2008 | Rapid Communication

Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3^null mice intrahepatic engrafted with cord blood-derived CD34⁺ cells

Authors: Seiji Okada, Hideki Harada, Takaaki Ito, Takashi Saito, Shinya Suzu

Published in: International Journal of Hematology | Issue 5/2008

Abstract

An animal model in which the human immune system can be reconstituted is necessary to study acquired immunity in vivo. We report here a novel model, the NOD/SCID/JAK3^null mouse, for the human immune system’s development. Newborn mice transplanted with human cord blood CD34⁺ cells intrahepatically, developed human T and B cells, and myeloid and plasmacytoid dendritic cells. The T and B cells had a naïve to memory phenotype, and included plasma cells. The human acquired immune system can be reconstituted from CD34⁺ cells in NOD/SCID/JAK3^null mice. This model is a powerful tool for the study of human immunity.

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Title: Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells
Authors: Seiji Okada
Hideki Harada
Takaaki Ito
Takashi Saito
Shinya Suzu
Publication date: 01-12-2008
Publisher: Springer Japan
Published in: International Journal of Hematology / Issue 5/2008
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-008-0215-z

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