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Open Access 01-12-2010 | Study protocol

Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial

Authors: Esther Hafkamp-de Groen, Ashna D Mohangoo, Johan C de Jongste, Johannes C van der Wouden, Henriëtte A Moll, Vincent WV Jaddoe, Albert Hofman, Harry J de Koning, Hein Raat

Published in: BMC Public Health | Issue 1/2010

Abstract

Background

Prevention of childhood asthma is an important public health objective. This study evaluates the effectiveness of early detection of preschool children with asthma symptoms, followed by a counselling intervention at preventive child health centres. Early detection and counselling is expected to reduce the prevalence of asthma symptoms and improve health-related quality of life at age 6 years.

Methods/design

This cluster randomised controlled trial was embedded within the Rotterdam population-based prospective cohort study Generation R in which 7893 children (born between April 2002 and January 2006) participated in the postnatal phase. Sixteen child health centres are involved, randomised into 8 intervention and 8 control centres. Since June 2005, an early detection tool has been applied at age 14, 24, 36 and 45 months at the intervention centres. Children who met the intervention criteria received counselling intervention (personal advice to parents to prevent smoke exposure of the child, and/or referral to the general practitioner or asthma nurse). The primary outcome was asthma diagnosis at age 6 years. Secondary outcomes included frequency and severity of asthma symptoms, health-related quality of life, fractional exhaled nitric oxide and airway resistance at age 6 years. Analysis was according to the intention-to-treat principle. Data collection will be completed end 2011.

Discussion

This study among preschool children provides insight into the effectiveness of early detection of asthma symptoms followed by a counselling intervention at preventive child health centres.

Trial registration

Current Controlled Trials ISRCTN15790308.

Available only for authorised users

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/10/555/prepub

Title: Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial
Authors: Esther Hafkamp-de Groen
Ashna D Mohangoo
Johan C de Jongste
Johannes C van der Wouden
Henriëtte A Moll
Vincent WV Jaddoe
Albert Hofman
Harry J de Koning
Hein Raat
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: BMC Public Health / Issue 1/2010
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/1471-2458-10-555

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial

Abstract

Background

Methods/design

Discussion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods/design

Discussion

Trial registration

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