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Clinical and Translational Allergy
Published in: Clinical and Translational Allergy 1/2017

Open Access 01-12-2017 | Research

Early childhood risk factors for rhinoconjunctivitis in adolescence: a prospective birth cohort study

Authors: Elisabeth Soegaard Christiansen, Henrik Fomsgaard Kjaer, Esben Eller, Carsten Bindslev-Jensen, Arne Høst, Charlotte Gotthard Mortz, Susanne Halken

Published in: Clinical and Translational Allergy | Issue 1/2017

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Abstract

Background

Rhinoconjunctivitis is a global health problem and one of the most common chronic conditions in children. Development of rhinoconjunctivitis depends on both genetic and environmental factors. Many studies have investigated rhinoconjunctivitis, but only few studies have evaluated the risk factors for non-allergic rhinoconjunctivitis in children finding family history of atopic diseases and gender to be of importance. The aim of this study was to investigate possible risk factors in early life for rhinoconjunctivitis, allergic as well as non-allergic, in adolescence.

Methods

The children in the Danish Allergy Research Center cohort were examined eight times from birth to 14 years of age. Visits included questionnaire-based interview, clinical examination, skin prick test and specific IgE. We used univariate and multivariate logistic regression to investigate the relationship between early-life risk factors and the development of rhinoconjunctivitis, allergic as well as non-allergic, in adolescence.

Results

Follow-up rate at 14-years was 66.2%. The prevalence of rhinoconjunctivitis was 32.8%. Family history of atopic diseases (aOR 2.25), atopic dermatitis (aOR 3.24), food allergy (aOR 3.89), early sensitization to inhalant and food allergens (aOR 2.92 and aOR 3.13) and male gender (aOR 1.90) were associated with allergic rhinoconjunctivitis but not with non-allergic rhinoconjunctivitis. Early environmental tobacco exposure was inversely associated with rhinoconjunctivitis (aOR 0.42), allergic (aOR 0.47) as well as non-allergic (aOR 0.43).

Conclusion

Different patterns of associations were revealed when stratifying rhinoconjunctivitis in allergic and non-allergic suggesting that allergic rhinoconjunctivitis and non-allergic-rhinoconjunctivitis are different phenotypes.
Literature
1.
Bousquet J, Schunemann HJ, Fonseca J, Samolinski B, Bachert C, Canonica GW, Casale T, Cruz AA, Demoly P, Hellings P, et al. MACVIA-ARIA sentinel network for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation. Allergy. 2015;70:1372–92.CrossRefPubMed
2.
Marinho S, Simpson A, Lowe L, Kissen P, Murray C, Custovic A. Rhinoconjunctivitis in 5-year-old children: a population-based birth cohort study. Allergy. 2007;62:385–93.CrossRefPubMed
3.
Westman M, Stjarne P, Asarnoj A, Kull I, van Hage M, Wickman M, Toskala E. Natural course and comorbidities of allergic and nonallergic rhinitis in children. J Allergy Clin Immunol. 2012;129:403–8.CrossRefPubMed
4.
Kellberger J, Dressel H, Vogelberg C, Leupold W, Windstetter D, Weinmayr G, Genuneit J, Heumann C, Nowak D, von Mutius E, Radon K. Prediction of the incidence and persistence of allergic rhinitis in adolescence: a prospective cohort study. J Allergy Clin Immunol. 2012;129:397–402.CrossRefPubMed
5.
Keil T, Bockelbrink A, Reich A, Hoffmann U, Kamin W, Forster J, Schuster A, Willich SN, Wahn U, Lau S. The natural history of allergic rhinitis in childhood. Pediatr Allergy Immunol. 2010;21:962–9.CrossRefPubMed
6.
Kurukulaaratchy RJ, Karmaus W, Raza A, Matthews S, Roberts G, Arshad SH. The influence of gender and atopy on the natural history of rhinitis in the first 18 years of life. Clin Exp Allergy. 2011;41:851–9.CrossRefPubMed
7.
Grabenhenrich LB, Keil T, Reich A, Gough H, Beschorner J, Hoffmann U, Bauer CP, Forster J, Schuster A, Schramm D, et al. Prediction and prevention of allergic rhinitis: a birth cohort study of 20 years. J Allergy Clin Immunol. 2015;136(932–940):e912.
8.
Kulig M, Bergmann R, Tacke U, Wahn U, Guggenmoos-Holzmann I. Long-lasting sensitization to food during the first two years precedes allergic airway disease. The MAS Study Group, Germany. Pediatr Allergy Immunol. 1998;9:61–7.CrossRefPubMed
9.
Arshad SH, Kurukulaaratchy RJ, Fenn M, Waterhouse L, Matthews S. Rhinitis in 10-year-old children and early life risk factors for its development. Acta Paediatr. 2002;91:1334–8.CrossRefPubMed
10.
Lodrup Carlsen KC, Roll S, Carlsen KH, Mowinckel P, Wijga AH, Brunekreef B, Torrent M, Roberts G, Arshad SH, Kull I, et al. Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts. PLoS ONE. 2012;7:e43214.CrossRefPubMedPubMedCentral
11.
Mitchell EA, Beasley R, Keil U, Montefort S, Odhiambo J. The association between tobacco and the risk of asthma, rhinoconjunctivitis and eczema in children and adolescents: analyses from phase three of the ISAAC programme. Thorax. 2012;67:941–9.CrossRefPubMed
12.
Magnusson LL, Olesen AB, Wennborg H, Olsen J. Wheezing, asthma, hayfever, and atopic eczema in childhood following exposure to tobacco smoke in fetal life. Clin Exp Allergy. 2005;35:1550–6.CrossRefPubMed
13.
Ulrik CS, von Linstow ML, Backer V. Prevalence and predictors of rhinitis in Danish children and adolescents. Allergy. 2000;55:1019–24.CrossRefPubMed
14.
15.
Westergaard T, Rostgaard K, Wohlfahrt J, Andersen PK, Aaby P, Melbye M. Sibship characteristics and risk of allergic rhinitis and asthma. Am J Epidemiol. 2005;162:125–32.CrossRefPubMed
16.
17.
Matheson MC, Dharmage SC, Abramson MJ, Walters EH, Sunyer J, de Marco R, Leynaert B, Heinrich J, Jarvis D, Norback D, et al. Early-life risk factors and incidence of rhinitis: results from the European Community Respiratory Health Study—an international population-based cohort study. J Allergy Clin Immunol. 2011;128(816–823):e815.
18.
Kjaer HF, Eller E, Host A, Andersen KE, Bindslev-Jensen C. The prevalence of allergic diseases in an unselected group of 6-year-old children. The DARC birth cohort study. Pediatr Allergy Immunol. 2008;19:737–45.CrossRefPubMed
19.
Westman M, Kull I, Lind T, Melen E, Stjarne P, Toskala E, Wickman M, Bergstrom A. The link between parental allergy and offspring allergic and nonallergic rhinitis. Allergy. 2013;68:1571–8.CrossRefPubMed
20.
Kleine-Tebbe J, Eickholt M, Gatjen M, Brunnee T, O’Connor A, Kunkel G. Comparison between MAGIC LITE-and CAP-system: two automated specific IgE antibody assays. Clin Exp Allergy. 1992;22:475–84.CrossRefPubMed
21.
Christiansen ES, Kjaer HF, Eller E, Bindslev-Jensen C, Host A, Mortz CG, Halken S. The prevalence of atopic diseases and the patterns of sensitization in adolescence. Pediatr Allergy Immunol. 2016;27:847–53.CrossRefPubMed
22.
Wahn U, von Mutius E. Childhood risk factors for atopy and the importance of early intervention. J Allergy Clin Immunol. 2001;107:567–74.CrossRefPubMed
23.
Belgrave DC, Granell R, Simpson A, Guiver J, Bishop C, Buchan I, Henderson AJ, Custovic A. Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies. PLoS Med. 2014;11:e1001748.CrossRefPubMedPubMedCentral
24.
Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med. 2000;343:538–43.CrossRefPubMed
25.
Kull I, Almqvist C, Lilja G, Pershagen G, Wickman M. Breast-feeding reduces the risk of asthma during the first 4 years of life. J Allergy Clin Immunol. 2004;114:755–60.CrossRefPubMed
26.
27.
Tinggaard J, Aksglaede L, Sorensen K, Mouritsen A, Wohlfahrt-Veje C, Hagen CP, Mieritz MG, Jorgensen N, Wolthers OD, Heuck C, et al. The 2014 Danish references from birth to 20 years for height, weight and body mass index. Acta Paediatr. 2014;103:214–24.CrossRefPubMed
28.
Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C, Cardona V, Dubois A, duToit G, Eigenmann P, et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy. 2014;69:1008–25.CrossRefPubMed
29.
Hannifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol. 1980;92(Suppl.):44–7.
30.
Hansen E. Social groups. Introduction to a study of one of the analytical tools for social research (in Danish). Soc Tidskr. 1977;53:1–18.
Metadata
Title
Early childhood risk factors for rhinoconjunctivitis in adolescence: a prospective birth cohort study
Authors
Elisabeth Soegaard Christiansen
Henrik Fomsgaard Kjaer
Esben Eller
Carsten Bindslev-Jensen
Arne Høst
Charlotte Gotthard Mortz
Susanne Halken
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Clinical and Translational Allergy / Issue 1/2017
Electronic ISSN: 2045-7022
DOI
https://doi.org/10.1186/s13601-017-0147-x

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