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01-08-2015 | Colorectal Cancer

Early and Late Outcomes of Surgery for Locally Recurrent Rectal Cancer: A Prospective 10-Year Study in the Total Mesorectal Excision Era

Authors: Mette Nielsen, MD, PhD, Peter Rasmussen, MD, Bodil Pedersen, MD, PhD, Rikke Hagemann-Madsen, MD, Jacob Lindegaard, MD, PhD, Søren Laurberg, DMSci, MD

Published in: Annals of Surgical Oncology | Issue 8/2015

Abstract

Aim

The aim of this study was to assess the outcome of all locally recurrent rectal cancer (LRRC) patients who were referred to a tertiary care center. The study examined LRRC patients who underwent surgery after prior total mesorectal excision.

Method

The data of 213 consecutive LRRC patients who were registered in a database between 2001 and 2010 were accessed.

Results

A total of 115 patients (54 %) with a median age of 63 (range 34–81) years underwent tumor resection. The 30-day mortality rate was 0.8 % (95 % CI 0.02–4 %), and the complication rate was 42 % (95 % CI 33–51 %). R0 resection was achieved in 70 patients (61 %), R1 resection in 38 patients (33 %), and R2 resection in 7 patients (6 %). The 3- and 5-year survival rates for R0 resections were 55 % (95 % CI 41–66) and 40 % (95 % CI 26–53), respectively; 42 % (95 % CI 26–58) and 16 % (95 % CI 5–31), respectively, for R1 resections; no patients who received an R2 resection survived to the 3-year mark. Patients with prior abdominoperineal excision (APE) had significantly poorer survival rates than patients with prior resection with anastomosis (p = 0.02).

Conclusion

Acceptable long-term survival can be achieved for patients undergoing surgery for LRRC, but radical resection is mandatory. Prior APE was associated with poorer survival rates.

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Title: Early and Late Outcomes of Surgery for Locally Recurrent Rectal Cancer: A Prospective 10-Year Study in the Total Mesorectal Excision Era
Authors: Mette Nielsen, MD, PhD
Peter Rasmussen, MD
Bodil Pedersen, MD, PhD
Rikke Hagemann-Madsen, MD
Jacob Lindegaard, MD, PhD
Søren Laurberg, DMSci, MD
Publication date: 01-08-2015
Publisher: Springer US
Published in: Annals of Surgical Oncology / Issue 8/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-014-4317-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Early and Late Outcomes of Surgery for Locally Recurrent Rectal Cancer: A Prospective 10-Year Study in the Total Mesorectal Excision Era

Abstract

Aim

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Aim

Method

Results

Conclusion

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