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Published in: BMC Psychiatry 1/2017

Open Access 01-12-2017 | Research article

Early adversity and psychiatric symptoms – a prospective study on Ethiopian mothers and their children

Authors: Johan Isaksson, Negussie Deyessa, Yemane Berhane, Ulf Högberg

Published in: BMC Psychiatry | Issue 1/2017

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Abstract

Background

Maternal exposure to adversity during the perinatal period has been associated with increased susceptibility for psychiatric symptoms in the offspring. The aim of this study was to investigate a possible developmental effect of maternal perinatal stressors on emotional and behavioural symptoms in the offspring in a developing country.

Methods

We followed an Ethiopian birth cohort (N = 358), assessing intimate partner violence (IPV) and maternal psychiatric symptoms during the perinatal period and at follow-up 10 years later, as a proxy for adversity, and maternal ratings on the Child Behavior Checklist (CBCL) 10 years later as the outcome.

Results

Among the women, exposure to IPV was common (60.6%) during the perinatal period and predicted IPV (29.9% of the mothers) at follow-up (ρ = 0.132; p = 0.012). There was also an association between maternal psychiatric symptoms at the two time points (ρ = 0.136; p = 0.010) and between maternal symptoms and IPV. Current maternal symptoms of anxiety and depression (β = 0.057; p < 0.001), but not during the perinatal period, were associated with child CBCL-scores.

Conclusion

Our findings do not support the hypothesis that early adversity increase susceptibility for psychiatric symptoms. However, the findings emphasize the public health problem of IPV in this population, adding to the women’s mental health problem.
Literature
1.
go back to reference Beijers R, Buitelaar JK, de Weerth C. Mechanisms underlying the effects of prenatal psychosocial stress on child outcomes: beyond the HPA axis. Eur Child Adolesc Psychiatry. 2014;23(10):943–56.CrossRefPubMed Beijers R, Buitelaar JK, de Weerth C. Mechanisms underlying the effects of prenatal psychosocial stress on child outcomes: beyond the HPA axis. Eur Child Adolesc Psychiatry. 2014;23(10):943–56.CrossRefPubMed
2.
go back to reference Deyessa N, Berhane Y, Emmelin M, Ellsberg MC, Kullgren G, Hogberg U. Joint effect of maternal depression and intimate partner violence on increased risk of child death in rural Ethiopia. Arch Dis Child. 2010;95(10):771–5.CrossRefPubMed Deyessa N, Berhane Y, Emmelin M, Ellsberg MC, Kullgren G, Hogberg U. Joint effect of maternal depression and intimate partner violence on increased risk of child death in rural Ethiopia. Arch Dis Child. 2010;95(10):771–5.CrossRefPubMed
3.
go back to reference Lupien SJ, McEwen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci. 2009;10(6):434–45.CrossRefPubMed Lupien SJ, McEwen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci. 2009;10(6):434–45.CrossRefPubMed
4.
go back to reference Valladares E, Pena R, Ellsberg M, Persson LA, Hogberg U. Neuroendocrine response to violence during pregnancy--impact on duration of pregnancy and fetal growth. Acta Obstet Gynecol Scand. 2009;88(7):818–23.CrossRefPubMed Valladares E, Pena R, Ellsberg M, Persson LA, Hogberg U. Neuroendocrine response to violence during pregnancy--impact on duration of pregnancy and fetal growth. Acta Obstet Gynecol Scand. 2009;88(7):818–23.CrossRefPubMed
5.
go back to reference Charil A, Laplante DP, Vaillancourt C, King S. Prenatal stress and brain development. Brain Res Rev. 2010;65(1):56–79.CrossRefPubMed Charil A, Laplante DP, Vaillancourt C, King S. Prenatal stress and brain development. Brain Res Rev. 2010;65(1):56–79.CrossRefPubMed
6.
go back to reference Sandman CA, Davis EP, Buss C, Glynn LM. Exposure to prenatal psychobiological stress exerts programming influences on the mother and her fetus. Neuroendocrinology. 2012;95(1):7–21.CrossRefPubMed Sandman CA, Davis EP, Buss C, Glynn LM. Exposure to prenatal psychobiological stress exerts programming influences on the mother and her fetus. Neuroendocrinology. 2012;95(1):7–21.CrossRefPubMed
7.
go back to reference Roberts AL, Lyall K, Rich-Edwards JW, Ascherio A, Weisskopf MG. Maternal exposure to intimate partner abuse before birth is associated with autism spectrum disorder in offspring. Autism. 2015;20(1):26–36.CrossRefPubMedPubMedCentral Roberts AL, Lyall K, Rich-Edwards JW, Ascherio A, Weisskopf MG. Maternal exposure to intimate partner abuse before birth is associated with autism spectrum disorder in offspring. Autism. 2015;20(1):26–36.CrossRefPubMedPubMedCentral
8.
go back to reference Lewis AJ, Austin E, Knapp R, Vaiano T, Galbally M. Perinatal maternal mental health, fetal programming and child development. Healthcare (Basel). 2015;3(4):1212–27.CrossRef Lewis AJ, Austin E, Knapp R, Vaiano T, Galbally M. Perinatal maternal mental health, fetal programming and child development. Healthcare (Basel). 2015;3(4):1212–27.CrossRef
9.
go back to reference Barker DJ. The developmental origins of chronic adult disease. Acta Paediatr Suppl. 2004;93(446):26–33.PubMed Barker DJ. The developmental origins of chronic adult disease. Acta Paediatr Suppl. 2004;93(446):26–33.PubMed
10.
go back to reference O'Donnell KJ, Meaney MJ. Fetal origins of mental health: the developmental origins of health and disease hypothesis. Am J Psychiatry. 2017;174(4):319–28.CrossRefPubMed O'Donnell KJ, Meaney MJ. Fetal origins of mental health: the developmental origins of health and disease hypothesis. Am J Psychiatry. 2017;174(4):319–28.CrossRefPubMed
11.
go back to reference van den Bergh BRH, van den Heuvel MI, Lahti M, Braeken M, de Rooij SR, Entringer S, Hoyer D, Roseboom T, Raikkonen K, King S, et al. Prenatal developmental origins of behavior and mental health: the influence of maternal stress in pregnancy. Neurosci Biobehav Rev. 2017; [Epub ahead of print] van den Bergh BRH, van den Heuvel MI, Lahti M, Braeken M, de Rooij SR, Entringer S, Hoyer D, Roseboom T, Raikkonen K, King S, et al. Prenatal developmental origins of behavior and mental health: the influence of maternal stress in pregnancy. Neurosci Biobehav Rev. 2017; [Epub ahead of print]
12.
13.
go back to reference Clavarino AM, Mamun AA, O'Callaghan M, Aird R, Bor W, O'Callaghan F, Williams GM, Marrington S, Najman JM, Alati R. Maternal anxiety and attention problems in children at 5 and 14 years. J Atten Disord. 2010;13(6):658–67.CrossRefPubMed Clavarino AM, Mamun AA, O'Callaghan M, Aird R, Bor W, O'Callaghan F, Williams GM, Marrington S, Najman JM, Alati R. Maternal anxiety and attention problems in children at 5 and 14 years. J Atten Disord. 2010;13(6):658–67.CrossRefPubMed
14.
go back to reference O'Donnell KJ, Glover V, Barker ED, O'Connor TG. The persisting effect of maternal mood in pregnancy on childhood psychopathology. Dev Psychopathol. 2014;26(2):393–403.CrossRefPubMed O'Donnell KJ, Glover V, Barker ED, O'Connor TG. The persisting effect of maternal mood in pregnancy on childhood psychopathology. Dev Psychopathol. 2014;26(2):393–403.CrossRefPubMed
15.
go back to reference Rodriguez A, Bohlin G. Are maternal smoking and stress during pregnancy related to ADHD symptoms in children? J Child Psychol Psychiatry. 2005;46(3):246–54.CrossRefPubMed Rodriguez A, Bohlin G. Are maternal smoking and stress during pregnancy related to ADHD symptoms in children? J Child Psychol Psychiatry. 2005;46(3):246–54.CrossRefPubMed
16.
go back to reference Martinez-Torteya C, Bogat GA, Levendosky AA, von Eye A. The influence of prenatal intimate partner violence exposure on hypothalamic-pituitary-adrenal axis reactivity and childhood internalizing and externalizing symptoms. Dev Psychopathol. 2016;28(1):55–72.CrossRefPubMed Martinez-Torteya C, Bogat GA, Levendosky AA, von Eye A. The influence of prenatal intimate partner violence exposure on hypothalamic-pituitary-adrenal axis reactivity and childhood internalizing and externalizing symptoms. Dev Psychopathol. 2016;28(1):55–72.CrossRefPubMed
17.
go back to reference Deyessa N, Berhane Y, Alem A, Ellsberg M, Emmelin M, Hogberg U, Kullgren G. Intimate partner violence and depression among women in rural Ethiopia: a cross-sectional study. Clin Pract Epidemiol Ment Health. 2009;5:8.CrossRefPubMedPubMedCentral Deyessa N, Berhane Y, Alem A, Ellsberg M, Emmelin M, Hogberg U, Kullgren G. Intimate partner violence and depression among women in rural Ethiopia: a cross-sectional study. Clin Pract Epidemiol Ment Health. 2009;5:8.CrossRefPubMedPubMedCentral
18.
go back to reference Garcia-Moreno C, Jansen HAFM, Ellsberg M, Heise L, Watts CH. Wo WM-CS: prevalence of intimate partner violence: findings from the WHO multi-country study on women's health and domestic violence. Lancet. 2006;368(9543):1260–9.CrossRefPubMed Garcia-Moreno C, Jansen HAFM, Ellsberg M, Heise L, Watts CH. Wo WM-CS: prevalence of intimate partner violence: findings from the WHO multi-country study on women's health and domestic violence. Lancet. 2006;368(9543):1260–9.CrossRefPubMed
19.
go back to reference Gossaye Y, Deyessa N, Berhane Y, Ellsberg M, Emmelin M, Ashenafi M, Alem A, Negash A, Kebede D, Kullgren G, Hogberg U. Women’s health and life events study in rural Ethiopia. Eth J Health Development. 2003;17(Second Special Issue):2–250. Gossaye Y, Deyessa N, Berhane Y, Ellsberg M, Emmelin M, Ashenafi M, Alem A, Negash A, Kebede D, Kullgren G, Hogberg U. Women’s health and life events study in rural Ethiopia. Eth J Health Development. 2003;17(Second Special Issue):2–250.
20.
go back to reference Deyessa N, Berhane Y, Alem A, Hogberg U, Kullgren G. Depression among women in rural Ethiopia as related to socioeconomic factors: a community-based study on women in reproductive age groups. Scand J Public Health. 2008;36(6):589–97.CrossRefPubMed Deyessa N, Berhane Y, Alem A, Hogberg U, Kullgren G. Depression among women in rural Ethiopia as related to socioeconomic factors: a community-based study on women in reproductive age groups. Scand J Public Health. 2008;36(6):589–97.CrossRefPubMed
21.
go back to reference Ali GC, Ryan G, De Silva MJ. Validated screening tools for common mental disorders in low and middle income countries: a systematic review. PLoS One. 2016;11(6):e0156939.CrossRefPubMedPubMedCentral Ali GC, Ryan G, De Silva MJ. Validated screening tools for common mental disorders in low and middle income countries: a systematic review. PLoS One. 2016;11(6):e0156939.CrossRefPubMedPubMedCentral
22.
go back to reference Kessler RC, Andrews G, Colpe LJ, Hiripi E, Mroczek DK, Normand SL, Walters EE, Zaslavsky AM. Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med. 2002;32(6):959–76.CrossRefPubMed Kessler RC, Andrews G, Colpe LJ, Hiripi E, Mroczek DK, Normand SL, Walters EE, Zaslavsky AM. Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med. 2002;32(6):959–76.CrossRefPubMed
23.
go back to reference Achenbach TM, Rescorla LA. Manual for the ASEBA School-age Forms & Profiles. Burlington, VT: University of Vermont, Research Centre for Children, Youth, & Families; 2001. Achenbach TM, Rescorla LA. Manual for the ASEBA School-age Forms & Profiles. Burlington, VT: University of Vermont, Research Centre for Children, Youth, & Families; 2001.
24.
go back to reference Achenbach TM, Rescorla LA, Ivanova MY. International epidemiology of child and adolescent psychopathology I: diagnoses, dimensions, and conceptual issues. J Am Acad Child Adolesc Psychiatry. 2012;51(12):1261–72.CrossRefPubMed Achenbach TM, Rescorla LA, Ivanova MY. International epidemiology of child and adolescent psychopathology I: diagnoses, dimensions, and conceptual issues. J Am Acad Child Adolesc Psychiatry. 2012;51(12):1261–72.CrossRefPubMed
25.
go back to reference Isaksson J, Lindblad F, Valladares E, Hogberg U. High maternal cortisol levels during pregnancy are associated with more psychiatric symptoms in offspring at age of nine - a prospective study from Nicaragua. J Psychiatr Res. 2015;71:97–102.CrossRefPubMed Isaksson J, Lindblad F, Valladares E, Hogberg U. High maternal cortisol levels during pregnancy are associated with more psychiatric symptoms in offspring at age of nine - a prospective study from Nicaragua. J Psychiatr Res. 2015;71:97–102.CrossRefPubMed
26.
go back to reference Waters CS, Hay DF, Simmonds JR, van Goozen SH. Antenatal depression and children's developmental outcomes: potential mechanisms and treatment options. Eur Child Adolesc Psychiatry. 2014;23(10):957–71.CrossRefPubMed Waters CS, Hay DF, Simmonds JR, van Goozen SH. Antenatal depression and children's developmental outcomes: potential mechanisms and treatment options. Eur Child Adolesc Psychiatry. 2014;23(10):957–71.CrossRefPubMed
27.
go back to reference Kieling C, Baker-Henningham H, Belfer M, Conti G, Ertem I, Omigbodun O, Rohde LA, Srinath S, Ulkuer N, Rahman A. Child and adolescent mental health worldwide: evidence for action. Lancet. 2011;378(9801):1515–25.CrossRefPubMed Kieling C, Baker-Henningham H, Belfer M, Conti G, Ertem I, Omigbodun O, Rohde LA, Srinath S, Ulkuer N, Rahman A. Child and adolescent mental health worldwide: evidence for action. Lancet. 2011;378(9801):1515–25.CrossRefPubMed
28.
go back to reference Fisher J. Cabral de Mello M, Patel V, Rahman a, Tran T, Holton S, Holmes W: prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: a systematic review. Bull World Health Organ. 2012;90(2):139G–49G.CrossRefPubMed Fisher J. Cabral de Mello M, Patel V, Rahman a, Tran T, Holton S, Holmes W: prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: a systematic review. Bull World Health Organ. 2012;90(2):139G–49G.CrossRefPubMed
29.
go back to reference Hanlon C, Medhin G, Selamu M, Breuer E, Worku B, Hailemariam M, Lund C, Prince M, Fekadu A. Validity of brief screening questionnaires to detect depression in primary care in Ethiopia. J Affect Disord. 2015;186:32–9.CrossRefPubMed Hanlon C, Medhin G, Selamu M, Breuer E, Worku B, Hailemariam M, Lund C, Prince M, Fekadu A. Validity of brief screening questionnaires to detect depression in primary care in Ethiopia. J Affect Disord. 2015;186:32–9.CrossRefPubMed
Metadata
Title
Early adversity and psychiatric symptoms – a prospective study on Ethiopian mothers and their children
Authors
Johan Isaksson
Negussie Deyessa
Yemane Berhane
Ulf Högberg
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2017
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-017-1500-2

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