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26-04-2024 | Dystonia | Correspondence

Rare genetic disorders and the heightened importance of baseline motor examinations in children and adolescents experiencing a first episode of psychosis

Author: Mark Ainsley Colijn

Published in: European Child & Adolescent Psychiatry

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Excerpt

Movement disorders are well known side effects of antipsychotic medications, including parkinsonism, dystonia, and akathisia, as well as dyskinesia in chronically exposed individuals. As such, it is standard practice to regularly assess for the presence of motor abnormalities in patients with schizophrenia, including at baseline. Interestingly, even prior to D2 receptor antagonist exposure, individuals experiencing a first episode of psychosis commonly exhibit motor abnormalities [10] which are associated with the positive, negative, and cognitive symptoms of the illness [10], as well as with symptomatic/functional worsening longitudinally [6]. Additionally, individuals considered to be at Ultra-High-Risk for psychosis, as well as unaffected first-degree relatives of those diagnosed with a primary psychotic disorder, exhibit a greater burden of various motor abnormalities compared to controls [10]. …
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Metadata
Title
Rare genetic disorders and the heightened importance of baseline motor examinations in children and adolescents experiencing a first episode of psychosis
Author
Mark Ainsley Colijn
Publication date
26-04-2024
Publisher
Springer Berlin Heidelberg
Published in
European Child & Adolescent Psychiatry
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-024-02449-z