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Open Access 01-12-2022 | Dyspnea | Research

Acute effects of NIV on peripheral muscle function and aerobic performance in patients with chronic obstructive pulmonary disease: a pilot study

Authors: Mariana Galvão de Medeiros Nogueira, Gabriely Azevêdo Gonçalo Silva, Marcelo Henrique Tavares Marinho, Ozana de Fátima Costa Brito, Wouber Hérickson de Brito Vieira, Marcela Abbott Galvão Ururahy, Ivan Daniel Bezerra Nogueira, Ivanízia Soares da Silva, Patrícia Angélica de Miranda Silva Nogueira

Published in: BMC Pulmonary Medicine | Issue 1/2022

Abstract

Background

Non-invasive ventilation (NIV) reduces respiratory load and demands on peripheral muscles.

Methods

This study aims to evaluate the acute effects of bi-level NIV on peripheral muscle function during isokinetic exercise and aerobic performance in chronic obstructive pulmonary disease (COPD) patients. This is a pilot crossover study performed with a non-probabilistic sample of 14 moderate to very severe COPD patients. Procedures carried out in two days. Dyspnea, quality of life, lung function, respiratory muscle strength, functional capacity (6-min walk test—6MWT), and isokinetic assessment of the quadriceps were assessed. Blood samples (lactate, lactate dehydrogenase, and creatine kinase concentration) were also collected. Right after, NIV was performed for 30 min (bi-level or placebo, according to randomization) followed by new blood sample collection, 6MWT, and isokinetic dynamometer tests. Before and after evaluations, the subjective perception of dyspnea and fatigue in the lower limbs was quantified. After a wash-out period of seven days, participants returned, and all assessments were performed again.

Results

NIV showed improvements in perceived exertion and dyspnea after isokinetic exercise (p < 0.02 and p < 0.05, respectively).

Conclusions

NIV improves the perception of dyspnea and fatigue during the isokinetic exercise.

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Title: Acute effects of NIV on peripheral muscle function and aerobic performance in patients with chronic obstructive pulmonary disease: a pilot study
Authors: Mariana Galvão de Medeiros Nogueira
Gabriely Azevêdo Gonçalo Silva
Marcelo Henrique Tavares Marinho
Ozana de Fátima Costa Brito
Wouber Hérickson de Brito Vieira
Marcela Abbott Galvão Ururahy
Ivan Daniel Bezerra Nogueira
Ivanízia Soares da Silva
Patrícia Angélica de Miranda Silva Nogueira
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Dyspnea
Six Minute Walk Test
Dyspnea
Non-Invasive Ventilation
Chronic Obstructive Lung Disease
Fatigue
Published in: BMC Pulmonary Medicine / Issue 1/2022
Electronic ISSN: 1471-2466
DOI: https://doi.org/10.1186/s12890-022-02201-w

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