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Journal of Neurology
Published in: Journal of Neurology 10/2020

01-10-2020 | Dyspnea | Original Communication

Dyspnea after subthalamic deep brain stimulation in Parkinson’s disease: a case–control study

Authors: Sara Meoni, Ana C. Bradi, Pettarusp Wadia, Yu-Yan Poon, Elena Moro

Published in: Journal of Neurology | Issue 10/2020

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Abstract

Objective

Dyspnea can be present as non-motor symptom in patients with Parkinson’s disease (PD). Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor and non-motor symptoms in PD. However, new-onset dyspnea has been reported after DBS surgery. We have studied respiratory characteristics of PD patients with bilateral STN-DBS to assess the impact of DBS on pulmonary function.

Methods

STN-DBS PD patients with dyspnea after surgery (cases) were matched with STN-DBS PD patients without dyspnea (controls). Motor and pulmonary function were assessed with stimulation and without medication (on stim/off med), and without stimulation and medication (off stim/off med). Pulmonary function was investigated with spirometry and dyspnea with the Medical Research Council Dyspnea Scale (MRCDS) and the Borg Scale (BS).

Results

Seven cases (five men, 58.30 ± 6.70 years of age) and seven controls (six men, 61.10 ± 6.30 years of age) were enrolled. MRCDS and BS revealed the presence of dyspnea in both groups. No significant changes in pulmonary function were found in both cases and controls in on stim/off med vs. off stim/off med condition (p < 0.05), and in cases vs. controls in on stim/ off med condition (p < 0.05).

Conclusions

No impact of STN-DBS on pulmonary function was found in cases. Impaired perception of dyspnea and spread of stimulation surrounding the STN might account for new-onset dyspnea after DBS surgery. Dyspnea was detected also in controls using ad hoc questionnaires. Our findings suggest further investigation of this non-motor symptom in PD patients.
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Metadata
Title
Dyspnea after subthalamic deep brain stimulation in Parkinson’s disease: a case–control study
Authors
Sara Meoni
Ana C. Bradi
Pettarusp Wadia
Yu-Yan Poon
Elena Moro
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 10/2020
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-020-09976-0

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