Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Diagnostic Pathology
Published in: Diagnostic Pathology 1/2011

Open Access 01-12-2011 | Case Report

Dysgerminoma in a case of 46, XY pure gonadal dysgenesis (swyer syndrome): a case report

Authors: Yang Han, Yan Wang, Qingchang Li, Shundong Dai, Anguang He, Enhua Wang

Published in: Diagnostic Pathology | Issue 1/2011

Login to get access

Abstract

Simple 46, XY gonadal dysgenesis syndrome, also called Swyer syndrome, is known as pure gonadal dysgenesis. Individuals with the syndrome are characterized by 46, XY karyotype and phenotypically female with female genital appearance, normal Müllerian structures and absent testicular tissue. The condition usually first becomes apparent in adolescence with delayed puberty and primary amenorrhea due to the gonads have no hormonal or reproductive potential. Herein, we report a case of dysgerminoma diagnosed in a dysgenetic gonad of a 21-year-old patient with Swyer syndrome.
Appendix
Available only for authorised users
Literature
1.
2.
Guidozzi F, Ball J, Spurdle A: 46, XY pure gonadal dysgenesis (Swyer-James syndrome)--Y or Y not?: a review. Obstet Gynecol Surv. 1994, 49 (2): 138-146. 10.1097/00006254-199402000-00026.CrossRefPubMed
3.
Behzadian MA, Tho SP, McDonough PG: The presence of the testicular determining sequence, SRY, in 46, XY females with gonadal dysgenesis (Swyer syndrome). Am J Obstet Gynecol. 1991, 165 (6 Pt 1): 1887-1890.CrossRefPubMed
4.
Michalkiewicz W, Baron J, Przybora L: Incomplete Testicular Feminization Syndrome. (Clinical, Hormonal, and Histological Study of 3 Familial Cases). Endokrynologia Polska. 1965, 16: 205-216.PubMed
5.
Bisceglia M, Magro G, Ben Dor D: Familial complete androgen insensitivity syndrome (Morris syndrome or testicular feminization syndrome) in 2 sisters. Adv Anat Pathol. 2008, 15 (2): 113-117. 10.1097/PAP.0b013e318166aa3b.CrossRefPubMed
6.
Jones HW, Ferguson-Smith MA, Heller RH: Pathologic and Cytogenetic Findings in True Hermaphroditism; Report of 6 Cases and Review of 23 Cases from the Literature. Obstet Gynecol. 1965, 25: 435-447.PubMed
7.
Kim KR, Kwon Y, Joung JY, Kim KS, Ayala AG, Ro JY: True hermaphroditism and mixed gonadal dysgenesis in young children: a clinicopathologic study of 10 cases. Mod Pathol. 2002, 15 (10): 1013-1019. 10.1097/01.MP.0000027623.23885.0D.CrossRefPubMed
8.
Sohval AR: The Syndrome of Pure Gonadal Dysgenesis. Am J Med. 1965, 38: 615-625. 10.1016/0002-9343(65)90137-3.CrossRefPubMed
9.
Jones HW, Ferguson-Smith MA, Heller RH: The Pathology and Cytogenetics of Gonadal Agenesis. Am J Obstet Gynecol. 1963, 87: 578-600.PubMed
10.
Taylor H, Barter RH, Jacobson CB: Neoplasms of dysgenetic gonads. Am J Obstet Gynecol. 1966, 96 (6): 816-823.PubMed
11.
Coutin AS, Hamy A, Fondevilla M, Savigny B, Paineau J, Visset J: Pure 46XY gonadal dysgenesis. J Gynecol Obstet Biol Reprod (Paris). 1996, 25 (8): 792-796.
12.
13.
Ben Temime R, Chachial A, Attial L, Ghodbanel I, Makhloufl T, Koubaal A, Kourda N, Ben Jilani S, Dammak T, El May A, et al.: 46 XY pure gonadal dysgenesis with gonadoblastoma and dysgerminoma. La Tunisie medicale. 2008, 86 (7): 710-713.PubMed
14.
Maleki Z, Loveless M, Fraig M: Coexistence of gonadoblastoma and dysgerminoma in a dysgenetic gonad on touch preparation: a case report. Diagn Cytopathol. 2010, 39 (1): 42-44.CrossRef
15.
Casey AC, Bhodauria S, Shapter A, Nieberg R, Berek JS, Farias-Eisner R: Dysgerminoma: the role of conservative surgery. Gynecol Oncol. 1996, 63 (3): 352-357. 10.1006/gyno.1996.0335.CrossRefPubMed
Metadata
Title
Dysgerminoma in a case of 46, XY pure gonadal dysgenesis (swyer syndrome): a case report
Authors
Yang Han
Yan Wang
Qingchang Li
Shundong Dai
Anguang He
Enhua Wang
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2011
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-6-84

Other articles of this Issue 1/2011

Diagnostic Pathology 1/2011 Go to the issue

Case Report

Atypical burkitt's lymphoma transforming from follicular lymphoma

Research

Mucins Differently Expressed in Various Ampullary Adenocarcinomas

Case Report

Primary acantholytic squamous cell carcinoma of the cecum: a case report

Research

Decreased D2-40 and increased p16INK4A immunoreactivities correlate with higher grade of cervical intraepithelial neoplasia

Research

Changes of microRNAs-192, 196a and 203 correlate with Barrett's esophagus diagnosis and its progression compared to normal healthy individuals

Research

Immunohistochemical profiles of claudin-3 in primary and metastatic prostatic adenocarcinoma