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Molecular Cancer
Published in: Molecular Cancer 1/2014

Open Access 01-12-2014 | Review

Dynamics of double strand breaks and chromosomal translocations

Authors: Olga V Iarovaia, Mikhail Rubtsov, Elena Ioudinkova, Tatiana Tsfasman, Sergey V Razin, Yegor S Vassetzky

Published in: Molecular Cancer | Issue 1/2014

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Abstract

Chromosomal translocations are a major cause of cancer. At the same time, the mechanisms that lead to specific chromosomal translocations that associate different gene regions remain largely unknown. Translocations are induced by double strand breaks (DSBs) in DNA. Here we review recent data on the mechanisms of generation, mobility and repair of DSBs and stress the importance of the nuclear organization in this process.
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Metadata
Title
Dynamics of double strand breaks and chromosomal translocations
Authors
Olga V Iarovaia
Mikhail Rubtsov
Elena Ioudinkova
Tatiana Tsfasman
Sergey V Razin
Yegor S Vassetzky
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2014
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-13-249

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