Top

Annals of Nuclear Medicine

Published in:

01-01-2013 | Original Article

Dynamic sequence respiratory gated perfusion pulmonary SPECT without external tracking device

Authors: Kenta Sakaguchi, Makoto Hosono, Masakazu Otsuka, Kohei Hanaoka, Kimio Usami, Tatsuro Uto, Kazunari Ishii

Published in: Annals of Nuclear Medicine | Issue 1/2013

Abstract

Objective

The purpose of this study was to develop and evaluate a new method for respiratory gated pulmonary perfusion SPECT (RGPS) based on dynamic acquisition without using an external tracking device (ETD) or list-mode data acquisition.

Methods

In the phantom study, our method used a dynamic sequence technique, which was specified by sequences of 50-ms acquisition during 30 s per view of SPECT instead of using an ETD. For this purpose, we created a computer program that identified respiratory phases by calculating the center of activity (COA) in each dynamic frame image. We compared RGPS using the dynamic sequence acquisition (RGPS-DS) and RGPS using ETD (RGPS-ETD) in phantom studies employing a cylinder phantom filled with technetium-99m solution attached to an instrument providing a simple harmonic motion. In the patient study, RGPS-DS was applied to data collected from 3 patients during a routine study of Tc-MAA pulmonary perfusion SPECT.

Results

In the phantom study, the calculation of COA indicated a good agreement between RGPS-DS and RGPS-ETD. With an oscillatory phantom movement amplitude of 30 mm, the amplitudes determined by RGPS-DS and RGPS-ETD (28.36 and 27.58 mm, respectively) were identical on considering a pixel size of 4.66 mm for reconstructed SPECT images. In the patient study, applicability of our method to patient data was demonstrated.

Conclusions

We have showed the feasibility of our method to obtain RGPS without ETD, and conclude that RGPS-DS may be an innovative and efficient technique in respiratory gated pulmonary perfusion SPECT. Further studies with a larger number of patients should demonstrate the accuracy of our method.

Available only for authorised users

Osada H, Machida K, Honda N. Quantification of regional pulmonary flow with 9mTc-MAA SPECT and cine phase contrast MR imaging. Ann Nucl Med. 2002;16(6):423–9.PubMedCrossRef

Suga K, Kawakami Y, Koike H, Iwanaga H, Tokuda O, Okada M, et al. Lung ventilation-perfusion imbalance in pulmonary emphysema: assessment with automated V/Q quotient SPECT. Ann Nucl Med. 2010;24(4):269–77. doi:10.1007/s12149-010-0369-7.PubMedCrossRef

Suga K, Kawakami Y, Zaki M, Yamashita T, Matsumoto T, Matsunaga N. Pulmonary perfusion assessment with respiratory gated 99mTc macroaggregated albumin SPECT: preliminary results. Nucl Med Commun. 2004;25(2):183–93.PubMedCrossRef

Klein GJ, Reutter BW, Ho MH, Reed JH, Huesman RH. Real-time system for respiratory-cardiac gating in positron tomography. IEEE Trans Nucl Sci. 1998;45(4):2139–43.CrossRef

McNamara JE, Bruyant P, Johnson K, Feng B, Lehovich A, Gu S, et al. An assessment of a low-cost visual tracking system (VTS) to detect and compensate for patient motion during SPECT. IEEE Trans Nucl Sci. 2008;55(3):992–8. doi:10.1109/TNS.2008.915688.PubMedCrossRef

McNamara JE, Pretorius PH, Johnson K, Mukherjee JM, Dey J, Gennert MA, et al. A flexible multicamera visual-tracking system for detecting and correcting motion-induced artifacts in cardiac SPECT slices. Med Phys. 2009;36(5):1913–23.PubMedCrossRef

Mah D, Hanley J, Rosenzweig KE, Yorke E, Braban L, Ling CC, et al. Technical aspects of the deep inspiration breath-hold technique in the treatment of thoracic cancer. Int J Radiat Oncol Biol Phys. 2000;48(4):1175–85.PubMedCrossRef

Rosenzweig KE, Hanley J, Mah D, Mageras G, Hunt M, Toner S, et al. The deep inspiration breath-hold technique in the treatment of inoperable non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2000;48(1):81–7.PubMedCrossRef

Suga K, Kawakami Y, Iwanaga H, Tokuda O, Matsunaga N. Automated breath-hold perfusion SPECT/CT fusion images of the lungs. AJR Am J Roentgenol. 2007;189(2):455–63. doi:10.2214/ajr.06.1290.PubMedCrossRef

10.

Pazhenkottil AP, Buechel RR, Herzog BA, Nkoulou RN, Valenta I, Fehlmann U, et al. Ultrafast assessment of left ventricular dyssynchrony from nuclear myocardial perfusion imaging on a new high-speed gamma camera. Eur J Nucl Med Mol Imaging. 2010;37(11):2086–92. doi:10.1007/s00259-010-1507-0.PubMedCrossRef

11.

Buther F, Dawood M, Stegger L, Wubbeling F, Schafers M, Schober O, et al. List mode-driven cardiac and respiratory gating in PET. J Nucl Med. 2009;50(5):674–81. doi:10.2967/jnumed.108.059204.PubMedCrossRef

12.

Rietzel E, Chen GT, Choi NC, Willet CG. Four-dimensional image-based treatment planning: target volume segmentation and dose calculation in the presence of respiratory motion. Int J Radiat Oncol Biol Phys. 2005;61(5):1535–50. doi:10.1016/j.ijrobp.2004.11.037.PubMedCrossRef

13.

Okubo M, Nishimura Y, Nakamatsu K, Okumura M, Shibata T, Kanamori S, et al. Static and moving phantom studies for radiation treatment planning in a positron emission tomography and computed tomography (PET/CT) system. Ann Nucl Med. 2008;22(7):579–86. doi:10.1007/s12149-008-0166-8.PubMedCrossRef

14.

Bundschuh RA, Martinez-Moeller A, Essler M, Martinez MJ, Nekolla SG, Ziegler SI, et al. Postacquisition detection of tumor motion in the lung and upper abdomen using list-mode PET data: a feasibility study. J Nucl Med. 2007;48(5):758–63. doi:10.2967/jnumed.106.035279.PubMedCrossRef

15.

Nehmeh SA, Erdi YE, Ling CC, Rosenzweig KE, Schoder H, Larson SM, et al. Effect of respiratory gating on quantifying PET images of lung cancer. J Nucl Med. 2002;43(7):876–81.PubMed

16.

Lupi A, Zaroccolo M, Salgarello M, Malfatti V, Zanco P. The effect of 18F-FDG-PET/CT respiratory gating on detected metabolic activity in lung lesions. Ann Nucl Med. 2009;23(2):191–6. doi:10.1007/s12149-008-0225-1.PubMedCrossRef

17.

Okubo M, Nishimura Y, Nakamatsu K, Okumura M, Shibata T, Kanamori S, et al. Radiation treatment planning using positron emission and computed tomography for lung and pharyngeal cancers: a multiple-threshold method for [(18)F]fluoro-2-deoxyglucose activity. Int J Radiat Oncol Biol Phys. 2010;77(2):350–6. doi:10.1016/j.ijrobp.2009.05.025.PubMedCrossRef

Title: Dynamic sequence respiratory gated perfusion pulmonary SPECT without external tracking device
Authors: Kenta Sakaguchi
Makoto Hosono
Masakazu Otsuka
Kohei Hanaoka
Kimio Usami
Tatsuro Uto
Kazunari Ishii
Publication date: 01-01-2013
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 1/2013
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-012-0658-4

At a glance: The STEP trials

Springer Medicine

Dynamic sequence respiratory gated perfusion pulmonary SPECT without external tracking device

Abstract

Objective

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2013

Significant impact of transient deterioration of renal function on dosimetry in PRRT

A novel PET scanner with semiconductor detectors may improve diagnostic accuracy in the metastatic survey of head and neck cancer patients

Three-dimensional brain phantom containing bone and grey matter structures with a realistic head contour

Early response of patients undergoing concurrent chemoradiotherapy for cervical cancer: a comparison of PET/CT and MRI

The current status of an FDG-PET cancer screening program in Japan, based on a 4-year (2006–2009) nationwide survey

Predictive value of 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography/computed tomography for outcome of carbon ion radiotherapy in patients with head and neck mucosal malignant melanoma