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BMC Neurology

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Open Access 01-12-2022 | Study protocol

Dynamic molecular choreography of circadian rhythm disorders (DMCRD): a prospective cohort study protocol

Authors: Xiaoli Chen, Dongze Li, Yu Jia, Yanmei Liu, Yan Ma, Rui Zeng, Zhi Wan, Lei Ye

Published in: BMC Neurology | Issue 1/2022

Abstract

Background

Circadian rhythm disorders (CRDs) are closely associated with the occurrence and development of various diseases, such as inflammatory and cardiovascular diseases, as well as tumors. The impact of a CRD on bodily health is a complex and comprehensive process, and its molecular mechanisms and signaling pathways are still unclear. We therefore aimed to investigate the molecular mechanism variation and adverse outcomes associated with CRDs in a prospective cohort of CRD cases and controls at term using multiomics data. The study has been tasked with developing a precise health promotion model for the prevention and management of CRDs.

Methods

This will be a 5-year prospective cohort study centered on the health management of individuals with CRDs. One hundred volunteers were recruited and had undergone baseline specimen collection, health examination, and health assessment. All of them will be followed up every year using the same protocol, and their biological specimens will be subjected to multiomics analysis after standardized processing.

Discussion

Longitudinal health examination, health assessment, and multiomics data will be analyzed to study the impact of CRDs on the volunteers’ health status. The results of this study will promote the development of targeted health management programs based on precision medicine.

Trial registration

The clinical study registration has been completed (Trial Registration No. ChiCTR2100047242).

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Title: Dynamic molecular choreography of circadian rhythm disorders (DMCRD): a prospective cohort study protocol
Authors: Xiaoli Chen
Dongze Li
Yu Jia
Yanmei Liu
Yan Ma
Rui Zeng
Zhi Wan
Lei Ye
Publication date: 01-12-2022
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2022
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-022-02799-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dynamic molecular choreography of circadian rhythm disorders (DMCRD): a prospective cohort study protocol

Abstract

Background

Methods

Discussion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Discussion

Trial registration

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