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01-01-2006 | Experimental

Dynamic alveolar mechanics in four models of lung injury

Authors: Joseph D. DiRocco, Lucio A. Pavone, David E. Carney, Charles J. Lutz, Louis A. Gatto, Steve K. Landas, Gary F. Nieman

Published in: Intensive Care Medicine | Issue 1/2006

Abstract

Objective

To determine whether pathological alterations in alveolar mechanics (i.e., the dynamic change in alveolar size and shape with ventilation) at a similar level of lung injury vary depending on the cause of injury.

Design and setting

Prospective controlled animal study in a university laboratory.

Subjects

30 male Sprague-Dawley rats (300–550 g).

Interventions

Rats were separated into one of four lung injury models or control (n=6): (a) 2% Tween-20 (Tween, n=6), (b) oleic acid (OA, n=6), (c) ventilator-induced lung injury (VILI, PIP 40/ZEEP, n=6), (d) endotoxin (LPS, n=6). Alveolar mechanics were assessed at baseline and after injury (PaO₂/FIO₂ <300 mmHg) by in vivo microscopy.

Measurements

Alveolar instability (proportional change in alveolar size during ventilation) was used as a measurement of alveolar mechanics.

Results

Alveoli were unstable in Tween, OA, and VILI as hypoxemia developed (baseline vs. injury: Tween, 7±2% vs. 67±5%; OA: 3±2% vs. 82±9%; VILI, 4±2% vs. 72±5%). Hypoxemia after LPS was not associated with significant alveolar instability (baseline vs. injury: LPS, 3±2 vs. 8±5%).

Conclusions

These data demonstrate that multiple pathological changes occur in dynamic alveolar mechanics. The nature of these changes depends upon the mechanism of lung injury.

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Title: Dynamic alveolar mechanics in four models of lung injury
Authors: Joseph D. DiRocco
Lucio A. Pavone
David E. Carney
Charles J. Lutz
Louis A. Gatto
Steve K. Landas
Gary F. Nieman
Publication date: 01-01-2006
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 1/2006
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-005-2854-3

At a glance: The STEP trials

Springer Medicine

Dynamic alveolar mechanics in four models of lung injury

Abstract

Objective

Design and setting

Subjects

Interventions

Measurements

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Design and setting

Subjects

Interventions

Measurements

Results

Conclusions

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