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Published in: European Journal of Pediatrics 6/2018

Open Access 01-06-2018 | Review

Dutch guideline for clinical foetal-neonatal and paediatric post-mortem radiology, including a review of literature

Authors: L. J. P. Sonnemans, M. E. M. Vester, E. E. M. Kolsteren, J. J. H. M. Erwich, P. G. J. Nikkels, P. A. M. Kint, R. R. van Rijn, W. M. Klein, On behalf of the Dutch post-mortem imaging guideline group

Published in: European Journal of Pediatrics | Issue 6/2018

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Abstract

Clinical post-mortem radiology is a relatively new field of expertise and not common practice in most hospitals yet. With the declining numbers of autopsies and increasing demand for quality control of clinical care, post-mortem radiology can offer a solution, or at least be complementary. A working group consisting of radiologists, pathologists and other clinical medical specialists reviewed and evaluated the literature on the diagnostic value of post-mortem conventional radiography (CR), ultrasonography, computed tomography (PMCT), magnetic resonance imaging (PMMRI), and minimally invasive autopsy (MIA). Evidence tables were built and subsequently a Dutch national evidence-based guideline for post-mortem radiology was developed. We present this evaluation of the radiological modalities in a clinical post-mortem setting, including MIA, as well as the recently published Dutch guidelines for post-mortem radiology in foetuses, neonates, and children. In general, for post-mortem radiology modalities, PMMRI is the modality of choice in foetuses, neonates, and infants, whereas PMCT is advised in older children. There is a limited role for post-mortem CR and ultrasonography. In most cases, conventional autopsy will remain the diagnostic method of choice.
Conclusion: Based on a literature review and clinical expertise, an evidence-based guideline was developed for post-mortem radiology of foetal, neonatal, and paediatric patients.
What is Known:
• Post-mortem investigations serve as a quality check for the provided health care and are important for reliable epidemiological registration.
• Post-mortem radiology, sometimes combined with minimally invasive techniques, is considered as an adjunct or alternative to autopsy.
What is New:
• We present the Dutch guidelines for post-mortem radiology in foetuses, neonates and children.
• Autopsy remains the reference standard, however minimal invasive autopsy with a skeletal survey, post-mortem computed tomography, or post-mortem magnetic resonance imaging can be complementary thereof.
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Literature
23.
go back to reference Arthurs OJ, Guy A, Thayyil S, Wade A, Jones R, Norman W, Scott R, Robertson NJ, Jacques TS, Chong WK, Gunny R, Saunders D, Olsen OE, Owens CM, Offiah AC, Chitty LS, Taylor AM, Sebire NJ (2016) Comparison of diagnostic performance for perinatal and paediatric post-mortem imaging: CT versus MRI. Eur Radiol 26(7):2327–2336. https://doi.org/10.1007/s00330-015-4057-9 CrossRefPubMed Arthurs OJ, Guy A, Thayyil S, Wade A, Jones R, Norman W, Scott R, Robertson NJ, Jacques TS, Chong WK, Gunny R, Saunders D, Olsen OE, Owens CM, Offiah AC, Chitty LS, Taylor AM, Sebire NJ (2016) Comparison of diagnostic performance for perinatal and paediatric post-mortem imaging: CT versus MRI. Eur Radiol 26(7):2327–2336. https://​doi.​org/​10.​1007/​s00330-015-4057-9 CrossRefPubMed
26.
go back to reference Votino C, Jani J, Verhoye M, Bessieres B, Fierens Y, Segers V, Vorsselmans A, Kang X, Cos T, Foulon W, De Mey J, Cannie M (2012) Postmortem examination of human fetal hearts at or below 20 weeks’ gestation: a comparison of high-field MRI at 9.4 T with lower-field MRI magnets and stereomicroscopic autopsy. Ultrasound Obstet Gynecol 40(4):437–444. https://doi.org/10.1002/uog.11191 CrossRefPubMed Votino C, Jani J, Verhoye M, Bessieres B, Fierens Y, Segers V, Vorsselmans A, Kang X, Cos T, Foulon W, De Mey J, Cannie M (2012) Postmortem examination of human fetal hearts at or below 20 weeks’ gestation: a comparison of high-field MRI at 9.4 T with lower-field MRI magnets and stereomicroscopic autopsy. Ultrasound Obstet Gynecol 40(4):437–444. https://​doi.​org/​10.​1002/​uog.​11191 CrossRefPubMed
28.
go back to reference Arthurs OJ, Thayyil S, Pauliah SS, Jacques TS, Chong WK, Gunny R, Saunders D, Addison S, Lally P, Cady E, Jones R, Norman W, Scott R, Robertson NJ, Wade A, Chitty L, Taylor AM, Sebire NJ (2015) Diagnostic accuracy and limitations of post-mortem MRI for neurological abnormalities in fetuses and children. Clin Radiol 70(8):872–880. https://doi.org/10.1016/j.crad.2015.04.008 CrossRefPubMed Arthurs OJ, Thayyil S, Pauliah SS, Jacques TS, Chong WK, Gunny R, Saunders D, Addison S, Lally P, Cady E, Jones R, Norman W, Scott R, Robertson NJ, Wade A, Chitty L, Taylor AM, Sebire NJ (2015) Diagnostic accuracy and limitations of post-mortem MRI for neurological abnormalities in fetuses and children. Clin Radiol 70(8):872–880. https://​doi.​org/​10.​1016/​j.​crad.​2015.​04.​008 CrossRefPubMed
30.
go back to reference Arthurs OJ, Thayyil S, Addison S, Wade A, Jones R, Norman W, Scott R, Robertson NJ, Chitty LS, Taylor AM, Sebire NJ, Offiah AC (2014) Diagnostic accuracy of postmortem MRI for musculoskeletal abnormalities in fetuses and children. Prenat Diagn 34(13):1254–1261. https://doi.org/10.1002/pd.4460 CrossRefPubMed Arthurs OJ, Thayyil S, Addison S, Wade A, Jones R, Norman W, Scott R, Robertson NJ, Chitty LS, Taylor AM, Sebire NJ, Offiah AC (2014) Diagnostic accuracy of postmortem MRI for musculoskeletal abnormalities in fetuses and children. Prenat Diagn 34(13):1254–1261. https://​doi.​org/​10.​1002/​pd.​4460 CrossRefPubMed
31.
go back to reference Thayyil S, Sebire NJ, Chitty LS, Wade A, Chong W, Olsen O, Gunny RS, Offiah AC, Owens CM, Saunders DE, Scott RJ, Jones R, Norman W, Addison S, Bainbridge A, Cady EB, Vita ED, Robertson NJ, Taylor AM (2013) Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study. Lancet 382(9888):223–233. https://doi.org/10.1016/s0140-6736(13)60134-8 CrossRefPubMed Thayyil S, Sebire NJ, Chitty LS, Wade A, Chong W, Olsen O, Gunny RS, Offiah AC, Owens CM, Saunders DE, Scott RJ, Jones R, Norman W, Addison S, Bainbridge A, Cady EB, Vita ED, Robertson NJ, Taylor AM (2013) Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study. Lancet 382(9888):223–233. https://​doi.​org/​10.​1016/​s0140-6736(13)60134-8 CrossRefPubMed
34.
go back to reference van Rijn RR, Beek EJ, van de Putte EM, Teeuw AH, Nikkels PG, Duijst WL, Nievelstein R-JA, Group DN (2017) The value of postmortem computed tomography in paediatric natural cause of death: a Dutch observational study. Pediatr Radiol 47(11):1514–1522CrossRefPubMedPubMedCentral van Rijn RR, Beek EJ, van de Putte EM, Teeuw AH, Nikkels PG, Duijst WL, Nievelstein R-JA, Group DN (2017) The value of postmortem computed tomography in paediatric natural cause of death: a Dutch observational study. Pediatr Radiol 47(11):1514–1522CrossRefPubMedPubMedCentral
36.
go back to reference Dubbins P, Price J, Johnson K, Maguire SA, Wall M, Jaspan T, Hobbs C, Stoodley N, Chapman S, Kemp AM (2008) Standards for radiological investigations of suspected non-accidental injury. Royal College of Paediatrics and Child Health, London Dubbins P, Price J, Johnson K, Maguire SA, Wall M, Jaspan T, Hobbs C, Stoodley N, Chapman S, Kemp AM (2008) Standards for radiological investigations of suspected non-accidental injury. Royal College of Paediatrics and Child Health, London
39.
go back to reference Wootton-Gorges SL, Soares BP, Alazraki AL, Anupindi SA, Blount JP, Booth TN, Dempsey ME, Falcone RA Jr, Hayes LL, Kulkarni AV, Partap S, Rigsby CK, Ryan ME, Safdar NM, Trout AT, Widmann RF, Karmazyn BK, Palasis S (2017) ACR appropriateness criteria(R) suspected physical abuse-child. J Am Coll Radiol 14(5s):S338–s349. https://doi.org/10.1016/j.jacr.2017.01.036 CrossRefPubMed Wootton-Gorges SL, Soares BP, Alazraki AL, Anupindi SA, Blount JP, Booth TN, Dempsey ME, Falcone RA Jr, Hayes LL, Kulkarni AV, Partap S, Rigsby CK, Ryan ME, Safdar NM, Trout AT, Widmann RF, Karmazyn BK, Palasis S (2017) ACR appropriateness criteria(R) suspected physical abuse-child. J Am Coll Radiol 14(5s):S338–s349. https://​doi.​org/​10.​1016/​j.​jacr.​2017.​01.​036 CrossRefPubMed
45.
go back to reference Votino C, Bessieres B, Segers V, Kadhim H, Razavi F, Condorelli M, Votino R, D'Ambrosio V, Cos T (2014) Minimally invasive fetal autopsy using three-dimensional ultrasound: a feasibility study. Ultrasound Obstet Gynecol. https://doi.org/10.1002/uog.14642 Votino C, Bessieres B, Segers V, Kadhim H, Razavi F, Condorelli M, Votino R, D'Ambrosio V, Cos T (2014) Minimally invasive fetal autopsy using three-dimensional ultrasound: a feasibility study. Ultrasound Obstet Gynecol. https://​doi.​org/​10.​1002/​uog.​14642
46.
go back to reference Cannie M, Votino C, Moerman P, Vanheste R, Segers V, Van Berkel K, Hanssens M, Kang X, Cos T, Kir M, Balepa L, Divano L, Foulon W, De Mey J, Jani J (2012) Acceptance, reliability and confidence of diagnosis of fetal and neonatal virtuopsy compared with conventional autopsy: a prospective study. Ultrasound Obstet Gynecol 39(6):659–665. https://doi.org/10.1002/uog.10079 CrossRefPubMed Cannie M, Votino C, Moerman P, Vanheste R, Segers V, Van Berkel K, Hanssens M, Kang X, Cos T, Kir M, Balepa L, Divano L, Foulon W, De Mey J, Jani J (2012) Acceptance, reliability and confidence of diagnosis of fetal and neonatal virtuopsy compared with conventional autopsy: a prospective study. Ultrasound Obstet Gynecol 39(6):659–665. https://​doi.​org/​10.​1002/​uog.​10079 CrossRefPubMed
49.
go back to reference Thayyil S, Cleary JO, Sebire NJ, Scott RJ, Chong K, Gunny R, Owens CM, Olsen OE, Offiah AC, Parks HG, Chitty LS, Price AN, Yousry TA, Robertson NJ, Lythgoe MF, Taylor AM (2009) Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet 374(9688):467–475. https://doi.org/10.1016/s0140-6736(09)60913-2 CrossRefPubMed Thayyil S, Cleary JO, Sebire NJ, Scott RJ, Chong K, Gunny R, Owens CM, Olsen OE, Offiah AC, Parks HG, Chitty LS, Price AN, Yousry TA, Robertson NJ, Lythgoe MF, Taylor AM (2009) Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet 374(9688):467–475. https://​doi.​org/​10.​1016/​s0140-6736(09)60913-2 CrossRefPubMed
54.
go back to reference Brouwers M, Kho ME, Browman GP, Cluzeau F, Feder G, Fervers B, Hanna S, Makarski J, on behalf of the AGREE Next Steps Consortium (2010) AGREE II: Advancing guideline development, reporting and evaluation in healthcare. Can Med Assoc J 182:E839–E842. https://doi.org/10.1503/cmaj.090449 CrossRef Brouwers M, Kho ME, Browman GP, Cluzeau F, Feder G, Fervers B, Hanna S, Makarski J, on behalf of the AGREE Next Steps Consortium (2010) AGREE II: Advancing guideline development, reporting and evaluation in healthcare. Can Med Assoc J 182:E839–E842. https://​doi.​org/​10.​1503/​cmaj.​090449 CrossRef
56.
57.
go back to reference Schünemann HJ, Wiercioch W, Etxeandia I, Falavigna M, Santesso N, Mustafa R, Ventresca M, Brignardello-Petersen R, Laisaar KT, Kowalski S, Baldeh T, Zhang Y, Raid U, Neumann I, Norris SL, Thornton J, Harbour R, Treweek S, Guyatt G, Alonso-Coello P, Reinap M, Brozek J, Oxman A, Akl EA (2014) Guidelines 2.0: systematic development of a comprehensive checklist for a successful guideline enterprise. CMAJ 186(3):E123–E142. https://doi.org/10.1503/cmaj.131237 CrossRefPubMedPubMedCentral Schünemann HJ, Wiercioch W, Etxeandia I, Falavigna M, Santesso N, Mustafa R, Ventresca M, Brignardello-Petersen R, Laisaar KT, Kowalski S, Baldeh T, Zhang Y, Raid U, Neumann I, Norris SL, Thornton J, Harbour R, Treweek S, Guyatt G, Alonso-Coello P, Reinap M, Brozek J, Oxman A, Akl EA (2014) Guidelines 2.0: systematic development of a comprehensive checklist for a successful guideline enterprise. CMAJ 186(3):E123–E142. https://​doi.​org/​10.​1503/​cmaj.​131237 CrossRefPubMedPubMedCentral
Metadata
Title
Dutch guideline for clinical foetal-neonatal and paediatric post-mortem radiology, including a review of literature
Authors
L. J. P. Sonnemans
M. E. M. Vester
E. E. M. Kolsteren
J. J. H. M. Erwich
P. G. J. Nikkels
P. A. M. Kint
R. R. van Rijn
W. M. Klein
On behalf of the Dutch post-mortem imaging guideline group
Publication date
01-06-2018
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 6/2018
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-018-3135-9

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