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Published in: Drugs 5/2014

01-04-2014 | Current Opinion

Dusty Punch Cards and an Eternal Enigma: High-Density Lipoproteins and Atherosclerosis

Authors: Marcus E. Kleber, Tanja B. Grammer, Ursula Kassner, Günther Silbernagel, Winfried März

Published in: Drugs | Issue 5/2014

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Abstract

Epidemiological, clinical, and experimental evidence has accumulated during the last decades suggesting that high-density lipoproteins (HDLs) may protect from atherosclerosis and its clinical consequences. However, more than 55 years after the first description of the link between HDL and heart attacks, many facets of the biochemistry, function, and clinical significance of HDL remain enigmatic. This applies particularly to the completely unexpected results that became available from some recent clinical trials of nicotinic acid and of inhibitors of cholesteryl ester transfer protein (CETP). The concept that raising HDL cholesterol by pharmacological means would decrease the risk of vascular disease has therefore been challenged.
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Metadata
Title
Dusty Punch Cards and an Eternal Enigma: High-Density Lipoproteins and Atherosclerosis
Authors
Marcus E. Kleber
Tanja B. Grammer
Ursula Kassner
Günther Silbernagel
Winfried März
Publication date
01-04-2014
Publisher
Springer International Publishing
Published in
Drugs / Issue 5/2014
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-014-0189-5

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