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HAND
Published in: HAND 1/2014

01-03-2014 | Review

Dupuytren's disease: current state of the art

Author: Mark Henry

Published in: HAND | Issue 1/2014

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Abstract

Background

This review article critically examines the current literature for Dupuytren's disease.

Methods

Five procedures are considered: dermofasciectomy, limited fasciectomy, segmental aponeurectomy, needle aponeurotomy, and collagenase injection. Studies regarding the efficacy of these treatments focus primarily on the initial degree of correction, rate of recurrence, and complications.

Results

No one treatment has been declared superior and substantial controversy exists. Comparison between studies has been hampered by the absence of uniform definitions for clinical success and measurable disease progression. Traditional post-operative care includes formal therapy and night splinting, but recent studies have questioned the value of these adjuncts.

Conclusion

The extent of involvement at which the surgeon should intervene was previously well accepted by convention, but as the paradigm shifts towards less invasive procedures, treatment may be offered at an earlier stage. Future research should be structured to recognize the value-based decision making used by patients when selecting treatment.
Literature
1.
Abe Y, Rokkaku T, Ofuchi W, et al. An objective method to evaluate the risk of recurrence and extension of Dupuytren's disease. J Hand Surg (Br). 2004;29(5):427–30.CrossRef
2.
Armstrong JR, Hurren JS, Logan AM. Dermofasciectomy in the management of Dupuytren's disease. J Bone Joint Surg Br. 2000;82(1):90–4.PubMedCrossRef
3.
Badalamente MA, Hurst LC. Enzyme injection as nonsurgical treatment of Dupuytren's disease. J Hand Surg [Am]. 2000;25(4):629–36.CrossRef
4.
Badalamente MA, Hurst LC. Efficacy and safety of injectable mixed collagenase subtypes in the treatment of Dupuytren's contracture. J Hand Surg [Am]. 2007;32(6):767–74.CrossRef
5.
Badalamente MA, Hurst LC, Hentz VR. Collagen as a clinical target: nonoperative treatment of Dupuytren's disease. J Hand Surg [Am]. 2002;27(5):788–98.CrossRef
6.
Bainbridge C, Gerber RA, Szczypa PP, et al. Efficacy of collagenase in patients who did and did not have previous hand surgery for Dupuytren's contracture. J Plast Surg Hand Surg. 2012;46(3–4):177–83.PubMedCentralPubMedCrossRef
7.
Balaguer T, David S, Ihrai T, et al. Histological staging and Dupuytren's disease recurrence or extension after surgical treatment: a retrospective study of 124 patients. J Hand Surg Eu. 2009;34(4):493–6.CrossRef
8.
Becker GW, Davis TR. The outcome of surgical treatments for primary Dupuytren's disease—a systematic review. J Hand Surg Eu. 2010;35(8):623–6.CrossRef
9.
Beyermann K, Prommersberger KJ, Jacobs C, et al. Severe contracture of the proximal interphalangeal joint in Dupuytren's disease: does capsuloligamentous release improve outcome? J Hand Surg (Br). 2004;29(3):240–3.CrossRef
10.
Budd HR, Larson D, Chojnowski A, et al. The QuickDASH score: a patient-reported outcome measure for Dupuytren's surgery. J Hand Ther. 2011;24(1):15–20.PubMedCrossRef
11.
Bulstrode NW, Jemec B, Smith PJ. The complications of Dupuytren's contracture surgery. J Hand Surg [Am]. 2005;30(5):1021–5.CrossRef
12.
Chen NC, Shauver MJ, Chung KC. Cost-effectiveness of open partial fasciectomy, needle aponeurotomy, and collagenase injection for Dupuytren contracture. J Hand Surg [Am]. 2011;36(11):1826–34.CrossRef
13.
Chen NC, Srinivasan RC, Shauver MJ, et al. A systematic review of outcomes of fasciotomy, aponeurectomy, and collagenase treatments for Dupuytren's contracture. HAND. 2011;6(3):250–5.PubMedCrossRef
14.
Citron N, Hearnden A. Skin tension in the aetiology of Dupuytren's disease; a prospective trial. J Hand Surg (Br). 2003;28(6):528–30.CrossRef
15.
Citron ND, Nunez V. Recurrence after surgery for Dupuytren's disease: a randomized trial of two skin incisions. J Hand Surg (Br). 2005;30(6):563–6.CrossRef
16.
Clibbon JJ, Logan AM. Palmar segmental aponeurectomy for Dupuytren's disease with metacarpophalangeal flexion contracture. J Hand Surg (Br). 2001;26(4):360–1.CrossRef
17.
Coert JH, Nerin JP, Meek MF. Results of partial fasciectomy for Dupuytren disease in 261 consecutive patients. Ann Plast Surg. 2006;57(1):13–7.PubMedCrossRef
18.
Crean SM, Gerber RA, Le Graverand MP, et al. The efficacy and safety of fasciectomy and fasciotomy for Dupuytren's contracture in European patients: a structured review of published studies. J Hand Surg Eu. 2011;36(5):396–407.CrossRef
19.
Denkler K. Surgical complications associated with fasciectomy for Dupuytren's disease: a 20-year review of the English literature. Eplasty. 2010;10:116–33.
20.
Desai SS, Hentz VR. The treatment of Dupuytren's disease. J Hand Surg [Am]. 2011;36(5):936–42.CrossRef
21.
Di Benedetti DB, Nguyen D, Zografos L, et al. Prevalence, incidence, and treatments of Dupuytren's disease in the United States: results from a population-based study. HAND. 2011;6:149–58.CrossRef
22.
Dias JJ, Braybrooke J. Dupuytren's contracture: an audit of the outcomes of surgery. J Hand Surg (Br). 2006;31(5):514–21.CrossRef
23.
Donaldson OW, Pearson D, Reynolds R, et al. The association between intraoperative correction of Dupuytren's disease and residual postoperative contracture. J Hand Surg Eu. 2010;35(3):220–3.CrossRef
24.
Eaton C. Percutaneous fasciotomy for Dupuytren's contracture. J Hand Surg [Am]. 2011;36:910–5.CrossRef
25.
Ebskov LB, Boeckstyns ME, Sorensen AI, et al. Results after surgery for severe Dupuytren's contracture: does a dynamic extension splint influence outcome? Scand J Plast Reconstr Surg Hand Surg. 2000;34(2):155–60.PubMedCrossRef
26.
Evans RB, Dell PC, Fiolkowski P. A clinical report of the effect of mechanical stress on functional results after fasciectomy for Dupuytren's contracture. J Hand Ther. 2002;15(4):331–9.PubMedCrossRef
27.
Foucher G, Medina J, Navarro R. Percutaneous needle aponeurotomy: complications and results. J Hand Surg (Br). 2003;28:427–31.CrossRef
28.
Gilpin D, Coleman S, Hall S, et al. Injectable collagenase clostridium histolyticum: a new nonsurgical treatment for Dupuytren's disease. J Hand Surg [Am]. 2010;35(12):2027–38.CrossRef
29.
Hall PN, Fitzgerald A, Sterne GD, et al. Skin replacement in Dupuytren's disease. J Hand Surg (Br). 1997;22(2):193–7.CrossRef
30.
Hindocha S, Stanley JK, Watson S, et al. Dupuytren's diathesis revisited: evaluation of prognostic indicators for risk of disease recurrence. J Hand Surg [Am]. 2006;31(10):1626–34.CrossRef
31.
Hovius SE, Kan HJ, Smit X, et al. Extensive percutaneous aponeurotomy and lipografting: a new treatment for Dupuytren disease. Plast Reconstr Surg. 2011;128(1):221–8.PubMedCrossRef
32.
Hurst LC, Badalamente MA, Hentz VR, et al. Injectable collagenase clostridium histolyticum for Dupuytren's contracture. N Engl J Med. 2009;361:968–79.PubMedCrossRef
33.
Jerosch-Herold C, Shepstone L, Chojnowski AJ, et al. Severity of contracture and self-reported disability in patients with Dupuytren's contracture referred for surgery. J Hand Ther. 2011;24(1):6–10.PubMedCrossRef
34.
Jerosch-Herold C, Shepstone L, Chojnowski AJ, et al. Night-time splinting after fasciectomy or dermo-fasciectomy for Dupuytren's contracture: a pragmatic, multi-centre, randomised controlled trial. BMC Musculoskeletal Disord. 2011;12:136.CrossRef
35.
McMillan C, Binhammer P. Steroid injection and needle aponeurotomy for Dupuytren contracture: a randomized controlled study. J Hand Surg [Am]. 2012;37(7):1307–12.CrossRef
36.
Misra A, Jain A, Ghazanfar R, et al. Predicting the outcome of surgery for the proximal interphalangeal joint in Dupuytren's disease. J Hand Surg [Am]. 2007;32(2):240–5.CrossRef
37.
Moermans JP. Long-term results after segmental aponeurectomy for Dupuytren's disease. J Hand Surg (Br). 1996;21(6):797–800.CrossRef
38.
Peimer CA, Blazar P, Coleman S, et al. Dupuytren contracture recurrence following treatment with collagenase clostridium histolyticum (CORDLESS study): 3-year data. J Hand Surg [Am]. 2013;38(1):12–22.CrossRef
39.
Pess GM, Pess RM, Pess RA. Results of needle aponeurotomy for Dupuytren contracture in over 1,000 fingers. J Hand Surg [Am]. 2012;37(4):651–6.CrossRef
40.
Rahr L, Sondergaard P, Bisgaard T, et al. Percutaneous needle fasciotomy for primary Dupuytren's contracture. J Hand Surg Eu. 2011;36(7):548–52.CrossRef
41.
Roush TF, Stern PJ. Results following surgery for recurrent Dupuytren's disease. J Hand Surg [Am]. 2000;25(2):291–6.CrossRef
42.
Shin EK, Jones NF. Minimally invasive technique for release of Dupuytren's contracture: segmental fasciectomy through multiple transverse incisions. HAND. 2011;6(3):256–9.PubMedCrossRef
43.
Skoff HD. The surgical treatment of Dupuytren's contracture: a synthesis of techniques. Plast Reconstr Surg. 2004;113(2):540–4.PubMedCrossRef
44.
Ullah AS, Dias JJ, Bhowal B. Does a 'firebreak' full-thickness skin graft prevent recurrence after surgery for Dupuytren's contracture?: a prospective, randomised trial. J Bone Joint Surg Br. 2009;91(3):374–8.PubMedCrossRef
45.
van Rijssen AL, Gerbrandy FS, ter Linden H, et al. A comparison of the direct outcomes of percutaneous needle fasciotomy and limited fasciectomy for Dupuytren's disease: a 6-week follow-up study. J Hand Surg [Am]. 2006;31(5):717–25.CrossRef
46.
van Rijssen AL, ter Linden H, Werker PM. Five-year results of a randomized clinical trial on treatment in Dupuytren's disease: percutaneous needle fasciotomy versus limited fasciectomy. Plast Reconstr Surg. 2012;129(2):469–77.PubMedCrossRef
47.
van Rijssen AL, Werker PM. Percutaneous needle fasciotomy in Dupuytren's disease. J Hand Surg (Br). 2006;31:498–501.CrossRef
48.
van Rijssen AL, Werker PMN. Percutaneous needle fasciotomy for recurrent Dupuytren Disease. J Hand Surg [Am]. 2012;37(9):1820–3.CrossRef
49.
Watt AJ, Curtin CM, Hentz VR. Collagenase injection as nonsurgical treatment of Dupuytren's disease: 8-year follow-up. J Hand Surg [Am]. 2010;35(4):534–9.CrossRef
50.
Weinzweig N, Culver JE, Fleegler EJ. Severe contractures of the proximal interphalangeal joint in Dupuytren's disease: combined fasciectomy with capsuloligamentous release versus fasciectomy alone. Plast Reconstr Surg. 1996;97(3):560–6.PubMedCrossRef
51.
Wilbrand S, Ekbom A, Gerdin B. The sex ratio and rate of reoperation for Dupuytren's contracture in men and women. J Hand Surg (Br). 1999;24(4):456–9.CrossRef
52.
Wilbrand S, Flodmark C, Ekbom A, et al. Activation markers of connective tissue in Dupuytren's contracture: relation to postoperative outcome. Scand J Plast Reconstr Surg Hand Surg. 2003;37(5):283–92.PubMedCrossRef
53.
Witthaut J, Jones G, Skrepnik N, et al. Efficacy and safety of collagenase clostridium histolyticum injection for Dupuytren contracture: short-term results from 2 open-label studies. J Hand Surg [Am]. 2013;38(1):2–11.CrossRef
Metadata
Title
Dupuytren's disease: current state of the art
Author
Mark Henry
Publication date
01-03-2014
Publisher
Springer US
Published in
HAND / Issue 1/2014
Print ISSN: 1558-9447
Electronic ISSN: 1558-9455
DOI
https://doi.org/10.1007/s11552-013-9563-0

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