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European Archives of Oto-Rhino-Laryngology

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18-08-2023 | Dupilumab | Rhinology

Effectiveness and rapidity on olfatory fuction recovery in CRS patients treated with Dupilumab: a real life prospective controlled study

Authors: Ignazio La Mantia, Egle Grigaliute, Martina Ragusa, Salvatore Cocuzza, Thomas Radulesco, Alberto Maria Saibene, Christian Calvo-Henriquez, Nicolas Fakhry, Justin Michel, Antonino Maniaci

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2024

Abstract

Background

Recovery of olfactory function plays a prominent role in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). While rates and timing of such recovery vary, monoclonal antibodies might yield better results which we aimed at evaluating with this study.

Methodology

A prospective controlled study was conducted at our tertiary otolaryngological center from April 1, 2021, to October 1, 2022, in CRSwNP patients. We included an active group (n = 60 patients) performing dupilumab treatment and a control group (n = 60 patients) treated with intranasal and oral corticosteroids. Primary endpoints were changes in smell visual analogical scale (VAS) and SS-I (Sniffin' Sticks-identification) scores, and olfactory recovery rate. The secondary efficacy endpoints were nasal obstruction, rhinorrhea, headache, SNOT-22, and nasal congestion score (NCS).

Results

At 6 months, the active group demonstrated better outcomes than control in SS-I scores (10.23 ± 4.21 vs.3.68 ± 3.08; p < 0.001). No significant differences were found in blood eosinophil count, SNOT-22, and NPS (p > 0.05 for all). Olfactory function in the treatment arm improved in 86.66% (52/60 cases), with normal scores in 48.33% (29/60), while the control group reported a lower recovery rate (3/60; 5%), with no normal olfaction cases. Log-rank comparison for Kaplan–Meier functions was statistically significant (p < 0.001), but no differences were found in subanalysis in the active group based on blood eosinophil count at baseline, SNOT-22, and NPS scores.

Conclusions

Patients who receive dupilumab treatment may experience a faster recovery of olfactory function compared to those receiving corticosteroid therapy. This result would be maintained regardless of the severity of type 2 CRSwNP inflammation, the volume of the polyps, or the patient's subjective symptomatology.

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Title: Effectiveness and rapidity on olfatory fuction recovery in CRS patients treated with Dupilumab: a real life prospective controlled study
Authors: Ignazio La Mantia
Egle Grigaliute
Martina Ragusa
Salvatore Cocuzza
Thomas Radulesco
Alberto Maria Saibene
Christian Calvo-Henriquez
Nicolas Fakhry
Justin Michel
Antonino Maniaci
Publication date: 18-08-2023
Publisher: Springer Berlin Heidelberg
Keyword: Dupilumab
Published in: European Archives of Oto-Rhino-Laryngology / Issue 1/2024
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-08184-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effectiveness and rapidity on olfatory fuction recovery in CRS patients treated with Dupilumab: a real life prospective controlled study

Abstract

Background

Methodology

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methodology

Results

Conclusions

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