Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

01-01-2013 | Neurophthalmology

DTI parameters of axonal integrity and demyelination of the optic radiation correlate with glaucoma indices

Authors: Georg Michelson, Tobias Engelhorn, Simone Wärntges, Ahmed El Rafei, Joachim Hornegger, Arnd Doerfler

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2013

Abstract

Background

In glaucoma, damage of retinal ganglion cells may continue to the linked optic radiations. This study investigates the correlation of glaucoma severity indicators with parameters of axonal and myelin integrity of the optic radiations.

Methods

In this observational case–control study, 13 patients with normal-tension glaucoma, 13 patients with primary open-angle glaucoma, and seven control subjects (mean age, 57.6 ± 12.5 years) were randomly selected for diffusion tensor imaging (DTI) of the optic radiations. The results of the frequency doubling test (FDT) and the HRT-based linear discriminant functions of Burk (BLDF) and Mikelberg (MLDF) were correlated with the mean of the fractional anisotropy (FA), apparent diffusion coefficient (ADC), and radial diffusivity (RD) of the optic radiations. Multiple correlation analysis, corrected for age, stage of cerebral microangiopathy, diagnosis group, and gender was conducted at increasing thresholds of linear anisotropy (C_L) to reduce mismeasurements because of complex fiber situations.

Results

The best correlations were found for BLDF with FA at C_L threshold 0.3 (0.594, p = 0.001), with ADC at C_L 0.4 (−0.511, p = 0.005), and with RD at C_L 0.4 (−0.585, p = 0.001). MLDF correlated with FA at C_L 0.4 (0.393, p = 0.035). The FDT score correlated with FA at C_L 0 (−0.491, p = 0.007) and with RD at C_L 0 (−0.375, p = 0.045).

Conclusions

In glaucoma, DTI-derived parameters of the axonal integrity (FA, ADC) and demyelination (RD) of the optic radiation are linked to HRT-based indices of glaucoma severity and to impairment of the spatial-temporal contrast sensitivity.

Available only for authorised users

Yücel YH, Zhang Q, Weinreb RN, Kaufman PL, Gupta N (2003) Effects of retinal ganglion cell loss on mango-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Prog Retin Eye Res 22:465–481PubMedCrossRef

Weber AJ, Chen H, Hubbard WC, Kaufman PL (2000) Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus. Invest Ophthalmol Vis Sci 41:1370–1379PubMed

Gupta N, Ang LC, Noël de Tilly L, Bidaisee L, Yücel YH (2006) Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Br J Ophthalmol 90:674–678PubMedCrossRef

van Swieten JC, van den Hout JH, van Ketel BA, Hijdra A, Wokke JH, van Gijn J (1991) Periventricular lesions in the white matter on magnetic resonance imaging in the elderly: a morphometric correlation with arteriolosclerosis and dilated perivascular spaces. Brain 114:761–774PubMedCrossRef

Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, Radner H, Lechner H (1993) Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 43:1683–1689PubMedCrossRef

Wong TY, Klein R, Sharrett AR, Couper DJ, Klein BE, Liao DP, Hubbard LD, Mosley TH, Investigators ARIC (2002) Atheroslerosis Risk in Communities Study. Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA 288:67–74PubMedCrossRef

Harris A, Sergott RC, Spaeth GL, Katz JL, Shoemaker JA, Martin BJ (1994) Color Doppler analysis of ocular vessel blood velocity in normal-tension glaucoma. Am J Ophthalmol 118:642–649PubMed

Schmidt R, Scheltens P, Erkinjuntti T, Pantoni L, Markus HS, Wallin A, Barkhof F, Fazekas F (2004) White matter lesion progression: a surrogate endpoint for trials in cerebral small-vessel disease. Neurology 63:139–144PubMedCrossRef

van Swieten JC, Geyskes GG, Derix MM, Peeck BM, Ramos LM, van Latum JC, van Gijn J (1991) Hypertension in the elderly is associated with white matter lesions and cognitive decline. Ann Neurol 30:825–830PubMedCrossRef

10.

Liao D, Cooper L, Cai J, Toole J, Bryan N, Burke G, Shahar E, Nieto J, Mosley T, Heiss G (1997) The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study. Neuroepidemiology 16:149–162PubMed

11.

Breteler MM, van Swieten JC, Bots ML, Grobbee DE, Claus JJ, van den Hout JH, van Harskamp F, Tanghe HL, de Jong PT, van Gijn J, Hofman A (1994) Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: The Rotterdam Study. Neurology 44:1246–1252PubMedCrossRef

12.

Wen W, Sachdev PS (2004) Extent and distribution of white matter hyperintensities in stroke patients: the Sydney Stroke Study. Stroke 35:2813–2819PubMedCrossRef

13.

Wong TY, Klein R, Klein BEK, Tielsch JM, Hubbard LD, Nieto FJ (2001) Retinal microvascular abnormalities and their relations with hypertension, cardiovascular diseases and mortality. Surv Ophthalmol 46:59–80PubMedCrossRef

14.

Pierpaoli C, Jezzard P, Basser PJ, Barnett A, DiChiro G (1996) Diffusion tensor MR imaging of the human brain. Radiology 201:637–648PubMed

15.

Sotak CH (2002) The role of diffusion tensor imaging in the evaluation of ischemic brain injury – a review. NMR Biomed 15(7–8):561–569PubMedCrossRef

16.

Xu J, Sun SW, Naismith RT, Snyder AZ, Cross AH, Song SK (2008) Assessing optic nerve pathology with diffusion MRI: from mouse to human. NMR Biomed 21(9):928–940PubMedCrossRef

17.

Dong Q, Welsh RC, Chenevert TL, Carlos RC, Maly-Sundgren P, Gomez-Hassan DM, Mukherji SK (2004) Clinical applications of diffusion tensor imaging. J Magn Reson Imaging 19(1):6–18PubMedCrossRef

18.

Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH (2003) Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. NeuroImage 20:1714–1722PubMedCrossRef

19.

Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, Cross AH (2002) Dysmyelination revealed through MRI as increased radial but unchanged axial diffusion of water. NeuroImage 17:1429–1436PubMedCrossRef

20.

Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M (1986) MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 161(2):401–407PubMed

21.

Burk RO, Noack H, Rohrschneider K, Volcker HE (1999) Prediction of glaucomatous visual field defects by reference plane independent three-dimensional optic nerve head parameters. In: Wall M, Wild JM (eds) Perimetry Update 1998/1999: Proceedings of the XIIIth International Perimetric Society Meeting, Gardone Riviera (BS), Italy, September 6–9, 1998, Kugler, The Hague, pp 463–474

22.

Mikelberg FS, Parfitt CM, Swindale NV, Graham SL, Drance SM, Gosine R (1995) Ability of the Heidelberg Retina Tomograph to detect early glaucomatous visual field loss. J Glaucoma 4(4):242–247PubMedCrossRef

23.

Patel SC, Friedman DS, Varadkar P, Robin AL (2000) Algorithm for interpreting the results of frequency doubling perimetry. Am J Ophthalmol 129(3):323–327PubMedCrossRef

24.

El-Rafei A, Engelhorn T, Wärntges S, Dörfler A, Hornegger J, Michelson G (2011) A framework for voxel-based morphometric analysis of the optic radiation using diffusion tensor imaging in glaucoma. Magn Reson Imaging 29(8):1076–1087

25.

Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S (2004) Fiber tract-based atlas of human white matter anatomy. Radiology 230(1):77–87PubMedCrossRef

26.

Castedo J, Duque A, Roa E, Rodrigo P (2006) Atlas of white matter anatomy with fiber tractography by diffusion tensor MRI. 18th Annual Meeting of the Swiss Society of Neuroradiology SGNR/SSNR, Geneva Switzerland. http://www.neurorgs.com/inv/Publi/Pdf/Poster%20Castedo.pdf. Accessed 27 August 2009

27.

UAMS (1997) The Anatomy Project. Nashville, TN: Parthenon Publishing Group, 1997. http://anatomy.uams.edu/AnatomyHTML/atlas_html/eye_38.html. Accessed 10 September 2009

28.

Peled S, Gudbjartsson H, Westin CF, Kikinis R, Jolesz FA (1998) Magnetic resonance imaging shows orientation and asymmetry of white matter fiber tracts. Brain Res 780(1):27–33PubMedCrossRef

29.

Kertesz A, Black SE, Tokar G, Benke T, Carr T, Nicholson L (1988) Periventricular and subcortical hyperintensities on magnetic resonance imaging. ‘Rims, caps, and unidentified bright objects’. Arch Neurol 45(4):404–408PubMedCrossRef

30.

Garaci FG, Bolacchi F, Cerulli A, Melis M, Spanò A, Cedrone C, Floris R, Simonetti G, Nucci C (2009) Optic nerve and optic radiation neurodegeneration in patients with glaucoma: in vivo analysis with 3-T diffusion-tensor MR imaging. Radiology 252(2):496–501PubMedCrossRef

31.

Hodapp E, Parrish RK, Anderson DR (1993) Clinical decisions in glaucoma. Mosby, St. Louis, MO

32.

Vickers JC, Schumer RA, Podos SM, Wang RF, Riederer BM, Morrison JH (1995) Differential vulnerability of neurochemically identified subpopulations of retinal neurons in a monkey model of glaucoma. Brain Res 680(1–2):23–35PubMedCrossRef

33.

Maddess T, Henry GH (1992) Performance of nonlinear visual units in ocular hypertension and glaucoma. Clin Vision Sci 7(5):371–383

34.

White AJ, Sun H, Swanson WH, Lee BB (2002) An examination of physiological mechanisms underlying the frequency-doubling illusion. Invest Ophthalmol Vis Sci 43(11):3590–3599PubMed

35.

Yücel YH, Zhang Q, Gupta N, Kaufman PL, Weinreb RN (2000) Loss of neurons in magnocellular and parvocellular layers of the lateral geniculate nucleus in glaucoma. Arch Ophthalmol 118:378–384PubMed

36.

Fechtner RD, Weinreb RN (1994) Mechanisms of optic nerve damage in primary open angle glaucoma. Surv Ophthalmol 39:23–42PubMedCrossRef

37.

Burk RO, Vihanninjoki K, Bartke T, Tuulonen A, Airaksinen PJ, Völcker HE, König JM (2000) Development of the standard reference plane for the Heidelberg Retina Tomograph. Graefes Arch Clin Exp Ophthalmol 238(5):375–384PubMedCrossRef

38.

Sun SW, Liang HF, Le TQ, Armstrong RC, Cross AH, Song SK (2006) Differential sensitivity of in vivo and ex vivo diffusion tensor imaging to evolving optic nerve injury in mice with retinal ischemia. NeuroImage 32(3):1195–1204PubMedCrossRef

39.

Sun S-W, Liang H-F, Cross AH, Song S-K (2008) Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging. NeuroImage 40(1):1–10PubMedCrossRef

40.

Barrick TR, Charlton RA, Clark CA, Markus HS (2010) White matter structural decline in normal ageing; a prospective longitudinal study using tract based spatial statistics. Neuroimage 51(2):565–577

41.

Hirsch JG, Bock M, Essig M, Schad LR (1999) Comparison of diffusion anisotropy measurements in combination with the FLAIR technique. Magn Reson Imaging 17:705–716PubMedCrossRef

42.

Basser PJ, Pierpaoli C (1996) Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111(3):209–219PubMedCrossRef

Title: DTI parameters of axonal integrity and demyelination of the optic radiation correlate with glaucoma indices
Authors: Georg Michelson
Tobias Engelhorn
Simone Wärntges
Ahmed El Rafei
Joachim Hornegger
Arnd Doerfler
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2013
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-011-1887-2

2024 ASCO Annual Meeting

Springer Medicine

DTI parameters of axonal integrity and demyelination of the optic radiation correlate with glaucoma indices

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2013

Analysis of internal astigmatism and higher order aberrations in eyes implanted with a new diffractive multifocal toric intraocular lens

Long-term outcome of primary versus secondary intraocular lens implantation after simultaneous removal of bilateral congenital cataract

Vitreous haemorrhage and ischemic retinopathy in a patient with CADASIL

Intraocular pressure after exposure to moderate altitude

Ranibizumab for serous macular detachment in branch retinal vein occlusions

Chemosensitivity of conjunctival melanoma cell lines to target-specific chemotherapeutic agents