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Pediatric Nephrology

Published in:

01-01-2016 | Original Article

Drugs as risk factors of acute kidney injury in critically ill children

Authors: Corina Glanzmann, Bernhard Frey, Priska Vonbach, Christoph R. Meier

Published in: Pediatric Nephrology | Issue 1/2016

Abstract

Background

Acute kidney injury (AKI) is a serious condition in critically ill children. Nephrotoxic medication exposure is a common contributing factor to AKI, but little literature is available in pediatrics. The aim of the present study was to assess potential associations between drugs and the risk of developing AKI.

Methods

We performed a retrospective case-control study in a pediatric intensive care unit (PICU). Cases were patients who developed AKI during PICU stay. Patients without AKI served as controls and were matched to cases by age and gender in a one-to-one ratio.

Results

One hundred case-control pairs were included. Cases were not statistically different from controls with regard to median weight and main diagnoses, but differed with regard to the need for mechanical ventilation, severity of illness, and median length of PICU stay. Multivariate models revealed a statistically significant higher risk of developing AKI for patients treated with metamizole, morphine, paracetamol, and tropisetron. A similar risk could be shown for medication groups, namely glucocorticoids, betalactam antibiotics, opioids, and non-steroidal anti-inflammatory drugs.

Conclusions

The results suggest that drugs are associated with acute renal dysfunction in critically ill children, but the multifactorial causes of AKI should be kept in mind.

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Title: Drugs as risk factors of acute kidney injury in critically ill children
Authors: Corina Glanzmann
Bernhard Frey
Priska Vonbach
Christoph R. Meier
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 1/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-015-3180-9

At a glance: The STEP trials

Springer Medicine

Drugs as risk factors of acute kidney injury in critically ill children

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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