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Canadian Journal of Anesthesia/Journal canadien d'anesthésie

Published in:

01-04-2009 | Editorials

Drug interactions: lipoxygenase inhibitors interfere with ropivacaine-induced vasoconstriction

Authors: Daisy T. Joo, MD, PhD, Gail K. Wong, MBBS

Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Issue 4/2009

Excerpt

Local anesthetics are used to facilitate analgesia through their inhibition of sensory nerve conduction.1 As sodium channel blockers,1 local anesthetics inhibit the propagation of action potentials along nerve axons participating in the transmission of pain signals through the peripheral and central nervous systems.2 Aside from sodium channel inhibition, it is now becoming clear that local anesthetics have actions on other important cellular components. In this issue of the Journal, Sung et al.3 explore the mechanisms of ropivacaine-induced vasoconstriction through the modulation of arachidonic acid metabolism and production of vasoactive leukotrienes. Their article raises the interesting possibility that existing drug therapies in patients can affect the pharmacokinetics of co-administered local anesthetics. …

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Title: Drug interactions: lipoxygenase inhibitors interfere with ropivacaine-induced vasoconstriction
Authors: Daisy T. Joo, MD, PhD
Gail K. Wong, MBBS
Publication date: 01-04-2009
Publisher: Springer-Verlag
Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Issue 4/2009
Print ISSN: 0832-610X
Electronic ISSN: 1496-8975
DOI: https://doi.org/10.1007/s12630-009-9062-5

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Drug interactions: lipoxygenase inhibitors interfere with ropivacaine-induced vasoconstriction

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Keynote webinar | Spotlight on medication adherence

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