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01-02-2004 | Poster presentation

Drotrecogin alfa (activated) in the subgroup of patients with multiple organ dysfunction (MOD) during a global, single-arm, open-label trial in adult patients with severe sepsis (ENHANCE): comparisons with PROWESS

Authors: J Vincent, G Bernard, J Dhainaut, J Janes, T Wright, C Gaillez

Published in: Critical Care | Special Issue 1/2004

Excerpt

Drotrecogin alfa (activated) (DrotAA) was associated with a significant survival advantage and a favorable benefit–risk profile in a phase 3 clinical trial (PROWESS, n = 1690) in adult patients with severe sepsis. The EMEA approved DrotAA for treatment of adult patients with severe sepsis and multiple organ failure. ENHANCE (n = 2378) was a single-arm, open-label trial of DrotAA in adult patients with severe sepsis. We compared relative efficacies of DrotAA in ENHANCE and PROWESS in the subgroup of patients with MOD. …

Title: Drotrecogin alfa (activated) in the subgroup of patients with multiple organ dysfunction (MOD) during a global, single-arm, open-label trial in adult patients with severe sepsis (ENHANCE): comparisons with PROWESS
Authors: J Vincent
G Bernard
J Dhainaut
J Janes
T Wright
C Gaillez
Publication date: 01-02-2004
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 1/2004
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc2582

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Drotrecogin alfa (activated) in the subgroup of patients with multiple organ dysfunction (MOD) during a global, single-arm, open-label trial in adult patients with severe sepsis (ENHANCE): comparisons with PROWESS

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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