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BMC Cancer
Published in: BMC Cancer 1/2006

Open Access 01-12-2006 | Case report

Dramatic tumour response to pemetrexed single-agent in an elderly patient with malignant peritoneal mesothelioma: a case report

Authors: Gianpiero Fasola, Fabio Puglisi, Alessandro Follador, Marianna Aita, Silvia Di Terlizzi, Ornella Belvedere

Published in: BMC Cancer | Issue 1/2006

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Abstract

Background

To date, there is no standard treatment for unresectable malignant peritoneal mesothelioma; either best supportive care or systemic chemotherapy with palliative intent are accepted options.

Case presentation

Here, we report the case of a 79-year old patient with malignant peritoneal mesothelioma who was treated with pemetrexed single-agent and obtained an impressive long-lasting response.

Conclusion

Single-agent pemetrexed is a treatment option for malignant peritoneal mesothelioma in selected elderly patients or in patients with unpaired performance status.
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Literature
1.
Britton M: The epidemiology of mesothelioma. Semin Oncol. 2002, 29: 18-25. 10.1053/sonc.2002.30237.CrossRefPubMed
2.
Robinson BWS, Musk AW, Lake RA: Malignant mesothelioma. Lancet. 2005, 366: 397-408. 10.1016/S0140-6736(05)67025-0.CrossRefPubMed
3.
Sugarbaker PH, Welch LS, Mohamed F, Glehen O: A review of peritoneal mesothelioma at the Washington Cancer Institute. Surg Oncol Clin North Am. 2003, 12 (3): 605-621, xi. 10.1016/S1055-3207(03)00045-0.CrossRef
4.
Ordonez NG: The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. Am J Surg Pathol. 2003, 27 (8): 1031-1051. 10.1097/00000478-200308000-00001.CrossRefPubMed
5.
Feldman AL, Libutti SK, Pingpank JF, Bartlett DL, Beresnev TH, Mavroukakis SM, Steinberg SM, Liewehr DJ, Kleiner DE, Alexander HR: Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy. J Clin Oncol. 2003, 21: 4560-4567. 10.1200/JCO.2003.04.150.CrossRefPubMed
6.
Scagliotti GV, Shin DM, Kindler HL, Vasconcelles MJ, Keppler U, Manigold C, Burris H, Gatzemeier , Blatter J, Symanowski JT, Rusthoven JJ: Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma. J Clin Oncol. 2003, 21: 1556-1561. 10.1200/JCO.2003.06.122.CrossRefPubMed
7.
Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, Gatzemeier U, Boyer M, Emri S, Manegold C, Niyikiza G, Paoletti P: Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003, 21 (14): 2636-44. 10.1200/JCO.2003.11.136.CrossRefPubMed
8.
Janne PA, Wozniak AJ, Belani CP, Keohan ML, Ross HJ, Polikoff JA, Mintzer DM, Taylor R, Ashland J, Ye Z, Monberg MJ, Obasaju CK: Open-label study of pemetrexed alone or in combination with cisplatin for the treatment of patients with peritoneal mesothelioma: outcomes of an expanded access program. Clin Lung Cancer. 2005, 7: 40-46.CrossRefPubMed
Metadata
Title
Dramatic tumour response to pemetrexed single-agent in an elderly patient with malignant peritoneal mesothelioma: a case report
Authors
Gianpiero Fasola
Fabio Puglisi
Alessandro Follador
Marianna Aita
Silvia Di Terlizzi
Ornella Belvedere
Publication date
01-12-2006
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2006
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-6-289

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