Top

BMC Oral Health

Published in:

Open Access 01-12-2021 | Doxycycline | Research article

Effect of tetracyclines on pulpal and periodontal healing after tooth replantation: a systematic review of human and animal studies

Authors: Mingmei Meng, Yandi Chen, Huidi Ren, Qiong Zhang, Song Chen, Xuedong Zhou, Jing Zou

Published in: BMC Oral Health | Issue 1/2021

Abstract

Background

Pulpal and periodontal healing are two main concerns of delayed replantation of avulsed teeth. The objective of this review was to evaluate the effectiveness of topical and systemic application of tetracyclines on pulpal and periodontal healing after tooth replantation.

Methods

A comprehensive electronic search was conducted in six databases. This systematic review was carried out according to Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.

Results

After exclusion of 246 irrelevant papers, 14 animal studies and one human study were included in this review. The human study showed that avulsed permanent teeth treated with doxycycline did not show a better clinical outcome for pulp and periodontal healing compared with treatment with normal saline. As for animal studies, significant more pulpal healing was observed in immature teeth treated with topical doxycycline in two researches, while another one study showed that there is no difference between teeth treated with normal saline and teeth treated with doxycycline. Systemic doxycycline exerted no significant effect on pulpal revascularization illustrated by one research. Only one out of four articles illustrated the positive effect of systemic tetracyclines on periodontal healing. One paper reported that intracanal application of demeclocycline promoted favorable periodontal healing. Two articles showed topical doxycycline contributed to favorable periodontal healing, while five studies showed no significant effect of topical tetracyclines on periodontal healing.

Conclusions

As a result of data heterogeneity and limitations of the studies, the effect of topical or systemic application of tetracyclines on pulpal and periodontal healing is inconclusive. More studies are required to get more clinically significant conclusions.

Hecova H, Tzigkounakis V, Merglova V, et al. A retrospective study of 889 injured permanent teeth. Dent Traumatol. 2010;26(6):466–75.PubMedCrossRef

Andreasen JO, Borum MK, Jacobsen HL, et al. Replantation of 400 avulsed permanent incisors. 1. Diagnosis of healing complications. Endod Dent Traumatol. 1995;11(2):51–8.PubMedCrossRef

Souza BDM, Dutra KL, Kuntze MM, et al. Incidence of root resorption after the replantation of avulsed teeth: a meta-analysis. J Endod. 2018;44(8):1216–27.PubMedCrossRef

Andreasen JO, Borum MK, Jacobsen HL, et al. Replantation of 400 avulsed permanent incisors. 4. Factors related to periodontal ligament healing. Endod Dent Traumatol. 1995;11(2):76–89.PubMedCrossRef

Andreasen JO, Borum MK, Jacobsen HL, et al. Replantation of 400 avulsed permanent incisors. 2. Factors related to pulpal healing. Endod Dent Traumatol. 1995;11(2):59–68.PubMedCrossRef

Andreasen JO, Borum MK, Andreasen FM. Replantation of 400 avulsed permanent incisors. 3. Factors related to root growth. Endod Dent Traumatol. 1995;11(2):69–75.PubMedCrossRef

Roskamp L, Westphalen VP, Lima JH, et al. The influence of atopy in the prognosis of the replantation of avulsed teeth. J Periodontol. 2009;80(7):1121–4.PubMedCrossRef

Roskamp L, Westphalen VD, Carneiro E, et al. Relationship between extra-alveolar time and atopy in the prognosis of the replantation of avulsed teeth. J Trauma. 2010;69(6):79–81.

Sinpreechanon P, Boonzong U, Sricholpech M. Comparative evaluation of periodontal ligament fibroblasts stored in different types of milk: effects on viability and biosynthesis of collagen. Eur J Oral Sci. 2019;127(4):323–32.PubMedCrossRef

10.

Osmanovic A, Halilovic S, Kurtovic-Kozaric A, et al. Evaluation of periodontal ligament cell viability in different storage media based on human PDL cell culture experiments: a systematic review. Dent Traumatol. 2018;34(6):384–93.PubMedCrossRef

11.

Wang G, Wang C, Qin M. A retrospective study of survival of 196 replanted permanent teeth in children. Dent Traumatol. 2019;35(4–5):251–8.PubMedCrossRef

12.

Petrovic B, Markovic D, Peric T, et al. Factors related to treatment and outcomes of avulsed teeth. Dent Traumatol. 2010;26(1):52–9.PubMedCrossRef

13.

Loo WT, Dou YD, Chou WK, et al. Thymosin alpha 1 provides short-term and long-term benefits in the reimplantation of avulsed teeth: a double-blind randomized control pilot study. Am J Emerg Med. 2008;26(5):574–7.PubMedCrossRef

14.

Caglar E, Tanboga I, Süsal S. Treatment of avulsed teeth with Emdogain: a case report. Dent Traumatol. 2005;21(1):51–3.PubMedCrossRef

15.

Barbizam JV, Massarwa R, da Silva LA, et al. Histopathological evaluation of the effects of variable extraoral dry times and enamel matrix proteins (enamel matrix derivatives) application on replanted dogs’ teeth. Dent Traumatol. 2015;31(1):29–34.PubMedCrossRef

16.

Tuna EB, Arai K, Tekkesin MS, et al. Effect of fibroblast growth factor and enamel matrix derivative treatment on root resorption after delayed replantation. Dent Traumatol. 2015;31(1):49–56.PubMedCrossRef

17.

Najeeb S, Siddiqui F, Khurshid Z, et al. Effect of bisphosphonates on root resorption after tooth replantation: a systematic review. Dent Traumatol. 2017;33(2):77–83.PubMedCrossRef

18.

Kum KY, Kwon OT, Spängberg LS, et al. Effect of dexamethasone on root resorption after delayed replantation of rat tooth. J Endod. 2003;29(12):810–3.PubMedCrossRef

19.

Coccia CT. A clinical investigation of root resorption rates in reimplanted young permanent incisors: a five-year study. J Endod. 1980;6(1):413–20.PubMedCrossRef

20.

Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H. Effects of a triple antibiotic solution on pulpal dynamics after intentionally delayed tooth replantation in mice. J Endod. 2014;40(10):1566–72.PubMedCrossRef

21.

Chen H, Teixeira FB, Ritter AL, et al. The effect of intracanal anti-inflammatory medicaments on external root resorption of replanted dog teeth after extended extra-oral dry time. Dent Traumatol. 2008;24(1):74–8.PubMedCrossRef

22.

Kwon Y, Ko H, Kim S, et al. The effect of cathepsin K inhibitor surface treatment on delayed tooth replantation in dogs. Dent Traumatol. 2018;34(3):201–7.PubMedCrossRef

23.

Cvek M, Cleaton-Jones P, Austin J, et al. Pulp revascularization in reimplanted immature monkey incisors–predictability and the effect of antibiotic systemic prophylaxis. Endod Dent Traumatol. 1990;6(4):157–69.PubMedCrossRef

24.

Cvek M, Cleaton-Jones P, Austin J, et al. Effect of topical application of doxycycline on pulp revascularization and periodontal healing in reimplanted monkey incisors. Endod Dent Traumatol. 1990;6(4):170–6.PubMedCrossRef

25.

Sae-Lim V, Wang CY, Trope M. Effect of systemic tetracycline and amoxicillin on inflammatory root resorption of replanted dogs’ teeth. Endod Dent Traumatol. 1998;14(5):216–20.PubMedCrossRef

26.

Sae-Lim V, Wang CY, Choi GW, et al. The effect of systemic tetracycline on resorption of dried replanted dogs’ teeth. Endod Dent Traumatol. 1998;14(3):127–32.PubMedCrossRef

27.

Ma KM, Sae-Lim V. The effect of topical minocycline on replacement resorption of replanted monkeys’ teeth. Dent Traumatol. 2003;19(2):96–102.PubMedCrossRef

28.

Ritter ALS, Ritter AV, Murrah V, et al. Pulp revascularization of replanted immature dog teeth after treatment with minocycline and doxycycline assessed by laser Doppler flowmetry, radiography, and histology. Dent Traumatol. 2004;20(2):75–84.PubMedCrossRef

29.

Yanpiset K, Trope M. Pulp revascularization of replanted immature dog teeth after different treatment methods. Endod Dent Traumatol. 2000;16(5):211–7.PubMedCrossRef

30.

Tsilingaridis G, Malmgren B, Skutberg C, et al. The effect of topical treatment with doxycycline compared to saline on 66 avulsed permanent teeth–a retrospective case-control study. Dent Traumatol. 2015;31(3):171–6.PubMedCrossRef

31.

Bryson EC, Levin L, Banchs F, et al. Effect of immediate intracanal placement of Ledermix Paste(R) on healing of replanted dog teeth after extended dry times. Dent Traumatol. 2002;18(6):316–21.PubMedCrossRef

32.

Gomes WD, Silva CA, Melo ME, et al. Delayed tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline. Dent Traumatol. 2015;31(6):448–56.PubMedCrossRef

33.

Melo ME, Silva CA, de Souza Gomes WD, et al. Immediate tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline. Clin Oral Investig. 2016;20(3):523–32.PubMedCrossRef

34.

Bryson EC, Levin L, Banchs F, et al. Effect of minocycline on healing of replanted dog teeth after extended dry times. Dent Traumatol. 2003;19(2):90–5.PubMedCrossRef

35.

Selvig KA, Bjorvatn K, Claffey N. Effect of stannous fluoride and tetracycline on repair after delayed replantation of root-planed teeth in dogs. Acta Odontol Scand. 1990;48(2):107–12.PubMedCrossRef

36.

Bjorvatn K, Selvig KA, Klinge B. Effect of tetracycline and SnF2 on root resorption in replanted incisors in dogs. Scand J Dent Res. 1989;97(6):477–82.PubMed

37.

Selvig KA, Bjorvatn K, Bogle GC, et al. Effect of stannous fluoride and tetracycline on periodontal repair after delayed tooth replantation in dogs. Scand J Dent Res. 1992;100(4):200–3.PubMed

38.

Pârvu AE, Alb SF, Crăciun A, et al. Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitis. Acta Pharmacol Sin. 2012;34(2):247–54.PubMedPubMedCentralCrossRef

39.

Otobe IF, de Sousa SO, Matthews RW, et al. White sponge naevus: improvement with tetracycline mouth rinse: report of four cases. Clin Exp Dermatol. 2007;32(6):749–51.PubMedCrossRef

40.

Geisler TM. Clinical considerations for regenerative endodontic procedures. Dent Clin N Am. 2012;56(3):603–26.PubMedCrossRef

41.

Park JB. Treatment of peri-implantitis with deproteinised bovine bone and tetracycline: a case report. Gerodontology. 2012;29(2):145–9.PubMedCrossRef

42.

Skulason S, Holbrook WP, Thormar H, et al. A study of the clinical activity of a gel combining monocaprin and doxycycline: a novel treatment for herpes labialis. J Oral Pathol Med. 2012;41(1):61–7.PubMedCrossRef

43.

Kennedy R, Alibhai M, Shakib K. Tetracycline: a cure all? Br J Oral Maxillofac Surg. 2014;52(4):382–3.PubMedCrossRef

44.

Golub LM, McNamara TF, D’Angelo G, et al. A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity. J Dent Res. 1987;66(8):1310–4.PubMedCrossRef

45.

Golub LM, Ramamurthy N, McNamara TF, et al. Tetracyclines inhibit tissue collagenase activity. A new mechanism in the treatment of periodontal disease. J Periodontal Res. 1984;19(6):651–5.PubMedCrossRef

46.

Keller DC, Carano A. Tetracycline effect on osteoclastic and osteoblastic activity. Gen Dent. 1995;43(1):60–3.PubMed

47.

Zaidi M, Moonga BS, Huang CL, et al. The effect of tetracyclines on quantitative measures of osteoclast morphology. Biosci Rep. 1993;13(3):175–82.PubMedCrossRef

48.

Terranova VP, Franzetti LC, Hic S, et al. A biochemical approach to periodontal regeneration: tetracycline treatment of dentin promotes fibroblast adhesion and growth. J Periodontal Res. 1986;21(4):330–7.PubMedCrossRef

49.

Chappuis V, von Arx T. Replantation of 45 avulsed permanent teeth: a 1-year follow-up study. Dent Traumatol. 2005;21(5):289–96.PubMedCrossRef

50.

Liu Y, Zhu Z, Sun CW, et al. Effects of topical application of doxycycline on avulsed permanent teeth. Shanghai Kou Qiang Yi Xue. 2019;28(6):640–3.PubMed

51.

Nam OH, Cheon K, Kim MS, et al. Evaluation of the periodontal and pulpal healing of replanted rat molars with doxycycline root conditioning. J Periodontal Implant Sci. 2019;49(3):148–57.PubMedPubMedCentralCrossRef

52.

Andreasen JO. The effect of pulp extirpation or root canal treatment on periodontal healing after replantation of permanent incisors in monkeys. J Endod. 1981;7(6):245–52.PubMedCrossRef

53.

Tronstad L. Root resorption–etiology, terminology and clinical manifestations. Endod Dent Traumatol. 1988;4(6):241–52.PubMedCrossRef

54.

Gunraj MN. Dental root resorption. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(6):647–53.PubMedCrossRef

55.

Fouad AF, Abbott PV, Tsilingaridis G, et al. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Dent Traumatol. 2020;36(4):331–42.PubMedCrossRef

56.

Rifkin BR, Vernillo AT, Golub LM. Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs. J Periodontol. 1993;64(Suppl 8):819–27.PubMedCrossRef

57.

Gu Y, Walker C, Ryan ME, et al. Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine. J Oral Microbiol. 2012;4:1–14.CrossRef

58.

Caton J, Ryan ME. Clinical studies on the management of periodontal diseases utilizing subantimicrobial dose doxycycline (SDD). Pharmacol Res. 2011;63(2):114–20.PubMedCrossRef

59.

Greenwald RA. The road forward: the scientific basis for tetracycline treatment of arthritic disorders. Pharmacol Res. 2011;64(6):610–3.PubMedCrossRef

60.

Monk E, Shalita A, Siegel DM. Clinical applications of non-antimicrobial tetracyclines in dermatology. Pharmacol Res. 2011;63(2):130–45.PubMedCrossRef

61.

Meier CR, Derby LE, Jick SS, et al. Antibiotics and risk of subsequent first-time acute myocardial infarction. JAMA. 1999;281(5):427–31.PubMedCrossRef

62.

Bokey L, Hugh TB. Oesophageal ulceration associated with doxycycline therapy. Med J Aust. 1975;1(8):236–7.PubMedCrossRef

63.

Baker PJ, Evans RT, Coburn RA, et al. Tetracycline and its derivatives strongly bind to and are released from the tooth surface in active form. J Periodontol. 1983;54(10):580–5.PubMedCrossRef

64.

Kim SG, Kim MH, Chae CH, et al. Downregulation of matrix metalloproteinases in hyperplastic dental follicles results in abnormal tooth eruption. BMB Rep. 2008;41(4):322–7.PubMedCrossRef

65.

Day PF, Duggal MS, High AS, et al. Discoloration of teeth after avulsion and replantation: results from a multicenter randomized controlled trial. J Endod. 2011;37(8):1052–7.PubMedCrossRef

66.

Chen BK, George R, Walsh LJ. Root discolouration following short-term application of steroid medicaments containing clindamycin, doxycycline or demeclocycline. Aust Endod J. 2012;38(3):124–8.PubMedCrossRef

67.

Bierman CW, Cann HM, Cohen SN, et al. Requiem for tetracyclines. Pediatrics. 1975;55(1):142–3.

68.

Peterson CD, Abbott PD. Tetracycline’s effects on teeth preclude use in children and pregnant or lactating women. Postgrad Med. 1984;76(7):24–34.PubMedCrossRef

69.

Andreasen JO, Andreasen FM. Textbook and color atlas of traumatic injuries to the teeth. 3rd ed. Copenhagen: Munksgaard; 1994.

Title: Effect of tetracyclines on pulpal and periodontal healing after tooth replantation: a systematic review of human and animal studies
Authors: Mingmei Meng
Yandi Chen
Huidi Ren
Qiong Zhang
Song Chen
Xuedong Zhou
Jing Zou
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Doxycycline
Minocycline
Tetracyclines
Published in: BMC Oral Health / Issue 1/2021
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-021-01615-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of tetracyclines on pulpal and periodontal healing after tooth replantation: a systematic review of human and animal studies

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2021

Biocompatibility of NeoMTA Plus® versus MTA Angelus as delayed furcation perforation repair materials in a dog model

Oral health-related quality of life in patients infected with HIV, Iran: a cross-sectional study

Effects of mouth breathing on facial skeletal development in children: a systematic review and meta-analysis

Results of an experimental study of subgingival cleaning effectiveness in the furcation area

Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma

CBCT evaluation of root canal morphology and anatomical relationship of root of maxillary second premolar to maxillary sinus in a western Chinese population