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International Journal of Colorectal Disease

Published in:

01-02-2013 | Original Article

Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer

Authors: Mo-Jin Wang, Yuan Li, Rui Wang, Cun Wang, Yong-Yang Yu, Lie Yang, Yi Zhang, Bin Zhou, Zong-Guang Zhou, Xiao-Feng Sun

Published in: International Journal of Colorectal Disease | Issue 2/2013

Abstract

Purpose

Recently, microRNA-124 (miR-124) has been demonstrated as a potential tumor suppressor in several types of cancers. However, the role of miR-124 in colorectal cancer remains unclear. This study was aimed at investigating the clinicopathological significance of miR-124 expression in colorectal cancer.

Methods

Quantitative real-time PCR was used to analyze miR-124 expression in 96 colorectal cancers and individual-matched normal mucosa samples. The expression of miR-124 was assessed for associations with clinicopathological characteristics using chi-square test. The survival curves were calculated by the Kaplan–Meier method. The influence of each variable on survival was examined by the Cox multivariate regression analysis.

Results

The miR-124 expression was significantly downregulated in colorectal cancer compared to normal mucosa (P = 0.001). In colorectal cancer, miR-124 decreased expression correlated significantly with the grade of differentiation (P = 0.021). Univariate survival analysis showed that the downregulated miR-124 was significantly correlated with worse prognosis, both in terms of overall survival (P = 0.017) and disease-free survival (DFS) (P = 0.014). Further, the downregulated miR-124 was demonstrated as a prognostic factor for overall survival (hazard ratio, HR = 4.634; 95 % confidence interval, CI, 1.731–12.404; P = 0.002) and DFS (HR = 4.533, 95 % CI 1.733–11.856, P = 0.002), independently of gender, age, location, maximum tumor size, depth of invasion, differentiation, and TNM stage.

Conclusions

MiR-124 may play a certain role in the development of colorectal cancer. The downregulation expression of miR-124 is an independent prognostic factor in patients with colorectal cancer.

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Title: Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer
Authors: Mo-Jin Wang
Yuan Li
Rui Wang
Cun Wang
Yong-Yang Yu
Lie Yang
Yi Zhang
Bin Zhou
Zong-Guang Zhou
Xiao-Feng Sun
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 2/2013
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-012-1550-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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