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Journal of Medical Case Reports

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Open Access 01-12-2007 | Case report

Down syndrome with microgranular variant of acute promyelocytic leukemia in a child: a case report

Authors: Deepali Jain, Tejinder Singh, Prerna Arora

Published in: Journal of Medical Case Reports | Issue 1/2007

Abstract

Background

Acute promyelocytic leukemia (APL) accounts for less than 10% of pediatric AML. Cases of APL in Down syndrome (DS) have been described in the literature rarely and it is rarer still to find the microgranular variant (M3v) of APL in trisomy 21 patients.

Case presentation

We present a case of a five-year-old female with Down syndrome diagnosed with acute promyelocytic leukemia (APL). She came to our hospital with bleeding manifestations. Blood and bone marrow examination revealed promyelocytes showing a few fine granules and occasional Auer rods. Based on this morphology and cytochemistry, a diagnosis of APL microgranular variant (M3v) was made.

Conclusion

This case report emphasizes the importance of a high index of suspicion in the diagnosis of acute promyelocytic leukemia microgranular variant in Down syndrome.

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Title: Down syndrome with microgranular variant of acute promyelocytic leukemia in a child: a case report
Authors: Deepali Jain
Tejinder Singh
Prerna Arora
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2007
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-1-147

At a glance: The STEP trials

Springer Medicine

Down syndrome with microgranular variant of acute promyelocytic leukemia in a child: a case report

Abstract

Background

Case presentation

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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