Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 9/2003

01-09-2003 | Short Communication

Dosimetry in leakage of 188Re-DTPA during intracoronary balloon brachytherapy

Authors: Jin Chul Paeng, Dong Soo Lee, Won Jun Kang, Han-Mo Yang, June-Key Chung, Jae Min Jeong, In-Ho Chae, Myoung-Mook Lee, Myung Chul Lee

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2003

Login to get access

Abstract

Rhenium-188 is reported to be one of the best radionuclides for intracoronary balloon brachytherapy. Among several preparations of 188Re available for brachytherapy, 188Re-diethylene triamine penta-acetic acid (DTPA) and 188Re-mercaptoacetyltriglycine (MAG3) are recommended owing to their rapid excretion via the renal system and the absence of accumulation in the thyroid. The aim of this study was to calculate the dose of radiation exposure in a real human accident. During a 4-year clinical trial of 188Re-DTPA balloon brachytherapy in 242 patients, there was one accident involving balloon leakage. Dosimetry was performed by both image-based and biological analysis. The radiation exposure to the whole body was calculated as 113 mGy by image-based analysis and 83 or 88 mGy by biological analysis, which was approximately half the reported dose in the case of 188Re-perrhenate. The radiation exposures to other vital organs were also within the tolerated ranges. We conclude that 188Re-DTPA has better clinical feasibility and safety for intracoronary balloon brachytherapy than 188Re-perrhenate.
Literature
1.
Kotzerke J, Hanke H, Hoher M. Endovascular brachytherapy for the prevention of restenosis after angioplasty. Eur J Nucl Med 2000; 27:223–236.CrossRefPubMed
2.
Amols HI, Reinstein LE, Weinberger J. Dosimetry of a radioactive coronary balloon dilatation catheter for treatment of neointimal hyperplasia. Am Assoc Phys Med 1996; 23:1783–1788.CrossRef
3.
Lin WY, Tsai SC, Hsieh BT, Lee TW, Ting G, Wang SJ. Evaluation of three rhenium-188 candidates for intravascular radiation therapy with liquid-filled balloons to prevent restenosis. J Nucl Cardiol 2000; 7:37–42.PubMed
4.
Lee J, Lee DS, Kim KM, Yeo JS, Cheon GJ, Kim SK, Ahn JY, Jeong JM, Chung JK, Lee MC. Dosimetry of rhenium-188 diethylene triamine penta-acetic acid for endovascular intra-balloon brachytherapy after coronary angioplasty. Eur J Nucl Med 2000; 27:76–82.PubMed
5.
Hausleiter J, Li A, Makkar R, Berman D, Robinson A, Litvack F, Eigler N, Whiting J. Leakage of a liquid188Re-filled balloon system during intracoronary brachytherapy: a case report. Cardiovasc Radiat Med 2000; 2:7–10.CrossRefPubMed
6.
Chae IH, Kim HS, Sohn DW, Oh BH, Lee MM, Park YB, Choe YS, Lee YW. Intracoronary brachytherapy with188Re-DTPA-filled balloon system after angioplasty—SPARE (Seoul National University Hospital Post-Angioplasty Rhenium) trial [abstract]. Circulation 2000; 102:II751.
7.
Stabin MG. MIRDOSE: personal computer software for internal dose assessment in nuclear medicine. J Nucl Med 1996; 37:538–546.PubMed
8.
Thierens H, Vral A, de Ridder L. Biological dosimetry using the micronucleus assay for lymphocytes: interindividual differences in dose response. Health Phys 1991; 61:623–630.PubMed
9.
Kotzerke J, Fenchel S, Guhlmann A, Stabin M, Rentschler M, Knapp FF Jr, Reske SN. Pharmacokinetics of99Tcm-pertechnetate and 188Re-perrhenate after oral administration of perchlorate: option for subsequent care after the use of liquid 188Re in a balloon catheter. Nucl Med Commun 1998; 19:795–801.PubMed
10.
Park SW, Hong MK, Moon DH, Oh SJ, Lee CW, Kim JJ, Park SJ. Treatment of diffuse in-stent restenosis with rotational atherectomy followed by radiation therapy with a rhenium-188-mercaptoacetyltriglycine-filled balloon. J Am Coll Cardiol 2001; 38:631–637.CrossRefPubMed
Metadata
Title
Dosimetry in leakage of 188Re-DTPA during intracoronary balloon brachytherapy
Authors
Jin Chul Paeng
Dong Soo Lee
Won Jun Kang
Han-Mo Yang
June-Key Chung
Jae Min Jeong
In-Ho Chae
Myoung-Mook Lee
Myung Chul Lee
Publication date
01-09-2003
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2003
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-003-1235-9

Other articles of this Issue 9/2003

European Journal of Nuclear Medicine and Molecular Imaging 9/2003 Go to the issue

Original Article

Efficiency of [18F]FDG PET in characterising renal cancer and detecting distant metastases: a comparison with CT

Controversies—Against

[Tc(CO)3]+ chemistry: a promising new concept for SPECT?

Erratum

Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells

Original Article

Body contour 180° pinhole SPET with or without tilted detector: a phantom study

Original Article

Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells

News & Views

16th International Meeting IRIST, May 2003, Capri, Italy