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Open Access 01-12-2016 | Letter

Does ulinastatin really reduce incidence of acute kidney injury after cardiac surgery?

Authors: Fu-Shan Xue, Gao-Pu Liu, Chao Sun

Published in: Critical Care | Issue 1/2016

Excerpt

In a retrospective analysis by Wan and colleagues [1], propensity score matching analysis showed that ulinastatin administration was associated with a decreased incidence of acute kidney injury (AKI) after cardiac surgery. Paradoxically, patient outcomes, including intensive care unit (ICU) length of stay, in-hospital length of stay, and mortality, were not significantly different between the ulinastatin and control groups, although AKI has been significantly associated with increased morbidity and mortality after cardiac surgery [2]. …

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Vives M, Wijeysundera D, Marczin N. Cardiac surgery-associated acute kidney injury. Interact Cardiovasc Thorac Surg. 2014;18:637–45.CrossRefPubMed

Layton JB, Hansen MK, Jakobsen CJ, Kshirsagar AV, Andreasen JJ, Hjortdal VE, et al. Statin initiation and acute kidney injury following elective cardiovascular surgery: a population cohort study in Denmark. Eur J Cardiothorac Surg. 2016;49:995–1000.CrossRefPubMed

Arora P, Rajagopalam S, Ranjan R, Kolli H, Singh M, Venuto R, et al. Preoperative use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is associated with increased risk for acute kidney injury after cardiovascular surgery. Clin J Am Soc Nephrol. 2008;3:1266–73.CrossRefPubMedPubMedCentral

Thakar CV, Arrigain S, Worley S, Yared JP, Paganini EP. A clinical score to predict acute renal failure after cardiac surgery. J Am Soc Nephrol. 2005;16:162–8.CrossRefPubMed

Lewicki M, Ng I, Schneider AG. HMG CoA reductase inhibitors (statins) for preventing acute kidney injury after surgical procedures requiring cardiac bypass. Cochrane Database Syst Rev. 2015;3:D10480.

Honore PM, Jacobs R, Hendrickx I, De Waele E, Van Gorp V, Spapen HD, et al. Peri-operative fluid strategy and post-operative acute kidney injury in cardiac surgery patients: any role for pre-operative statin therapy? Crit Care. 2015;19:453.CrossRefPubMedPubMedCentral

Thiele RH, Isbell JM, Rosner MH. AKI associated with cardiac surgery. Clin J Am Soc Nephrol. 2015;103:500–14.CrossRef

Title: Does ulinastatin really reduce incidence of acute kidney injury after cardiac surgery?
Authors: Fu-Shan Xue
Gao-Pu Liu
Chao Sun
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-016-1279-4

At a glance: The STEP trials

Springer Medicine

Does ulinastatin really reduce incidence of acute kidney injury after cardiac surgery?

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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