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01-02-2014 | Leading Article

Does Treatment of Psoriasis Reduce the Risk of Cardiovascular Disease?

Authors: Sarah Churton, Liza Brown, Thuzar M. Shin, Neil J. Korman

Published in: Drugs | Issue 2/2014

Abstract

Psoriasis is an inflammatory disease associated with multiple comorbidities and cardiovascular risk factors. Patients with psoriasis have an increased risk of cardiovascular disease (CVD) and cardiovascular death. It has been proposed that overlapping mechanisms of systemic inflammation contribute to the link between psoriasis and cardiovascular disease. Some psoriasis treatments decrease systemic inflammation, but the effect of psoriasis treatments on heart disease is unknown. In this review of 23 original research publications, we present preliminary evidence that some psoriasis therapies improve cardiovascular biomarkers and the incidence of cardiovascular risk. Phototherapy may reduce some inflammatory cytokines, but there is little evidence for a decreased risk of CVD outcomes. Both methotrexate and tumour necrosis factor-α inhibitors improve cardiovascular inflammatory biomarkers and improve CVD outcomes. Short-term data on interleukin-12/23 inhibitors are varied, but most data suggest there is not an increase in cardiovascular events.

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Title: Does Treatment of Psoriasis Reduce the Risk of Cardiovascular Disease?
Authors: Sarah Churton
Liza Brown
Thuzar M. Shin
Neil J. Korman
Publication date: 01-02-2014
Publisher: Springer International Publishing
Published in: Drugs / Issue 2/2014
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI: https://doi.org/10.1007/s40265-013-0173-5

At a glance: The STEP trials

Springer Medicine

Does Treatment of Psoriasis Reduce the Risk of Cardiovascular Disease?

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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