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01-12-2021 | Original Article

Does the relationship between 25-hydroxyvitamin D status and bone mass vary according to skin color in adults? Results of a Brazilian population-based study

Authors: Kátia Josiany Segheto, Leidjaira Lopes Juvanhol, Danielle Cristina Guimarães da Silva, Cristiane Junqueira de Carvalho, Fernanda Hansen, Mariana Papini Gabiatti, Adriana Maria Kakehasi, Giana Zarbato Longo

Published in: Archives of Osteoporosis | Issue 1/2021

Abstract

Summary

Skin color has been indicated as an important factor in determining serum concentrations of 25-hydroxyvitamin D [25(OH)D], and consequently bone health. However, studies are controversial and scarce for mixed populations.

Purpose/introduction

To analyze the association of 25(OH)D with bone mineral content (BMC) and bone mineral density (BMD); and to investigate the presence of interaction with skin color in Brazilian adults.

Methods

This is a cross-sectional, population-based study conducted with adult individuals (20–59 years) of both genders. Bone health was assessed by dual energy radiological absortometry. Vitamin D status was measured using serum 25(OH)D. Skin color and other variables in the adjusted model were collected using a questionnaire and anthropometric assessment. Associations and interactions were evaluated using linear regression models stratified according to gender.

Results

Non-white men with vitamin D deficiency (< 20.0 ng/mL) have less bone mass than those with insufficiency and sufficiency for the femoral neck and hip sites. According to the adjusted regression analysis, the deficient status of 25(OH)D in men was associated with worse bone health for the lumbar spine sites (β = − 0.1; p = 0.006), femoral neck (β = − 0.08; p = 0.006), and hip (β = − 0.08; p = 0.009). No statistically significant associations were observed between 25(OH)D and bone health in women. In addition, no statistical interaction was identified between skin color and vitamin D status in relation to bone health (p > 0.05 for all tests) in either gender and for all bone sites evaluated.

Conclusion

Deficient vitamin D status is associated with lower bone mass in adults with differences observed according to gender, but not according to skin color.

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Title: Does the relationship between 25-hydroxyvitamin D status and bone mass vary according to skin color in adults? Results of a Brazilian population-based study
Authors: Kátia Josiany Segheto
Leidjaira Lopes Juvanhol
Danielle Cristina Guimarães da Silva
Cristiane Junqueira de Carvalho
Fernanda Hansen
Mariana Papini Gabiatti
Adriana Maria Kakehasi
Giana Zarbato Longo
Publication date: 01-12-2021
Publisher: Springer London
Published in: Archives of Osteoporosis / Issue 1/2021
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-021-00876-y

At a glance: The STEP trials

Springer Medicine

Does the relationship between 25-hydroxyvitamin D status and bone mass vary according to skin color in adults? Results of a Brazilian population-based study

Abstract

Summary

Purpose/introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Purpose/introduction

Methods

Results

Conclusion

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