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Journal of Mammary Gland Biology and Neoplasia
Published in: Journal of Mammary Gland Biology and Neoplasia 1-2/2018

01-06-2018

Does the Mouse Mammary Gland Arise from Unipotent or Multipotent Mammary Stem/Progenitor Cells?

Authors: Gilbert H. Smith, Daniel Medina

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 1-2/2018

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Abstract

The presence of long-lived lineage restricted progenitor and multipotent progenitor cells in adult mouse mammary gland for cancer development is compelling. Mammary cancers are phenotypically diverse This might be explained by transformation of long-lived, lineage-limited progenitor subpopulations. Mammary multipotent epithelial stem cells and their environmental niches must be considered, since their niche(s), once empty might be occupied by lineage-limited progenitors that are proximal. The existence of premalignant mammary populationst that manifest characteristics of lineage limitation argues strongly for this proposition.
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Metadata
Title
Does the Mouse Mammary Gland Arise from Unipotent or Multipotent Mammary Stem/Progenitor Cells?
Authors
Gilbert H. Smith
Daniel Medina
Publication date
01-06-2018
Publisher
Springer US
Published in
Journal of Mammary Gland Biology and Neoplasia / Issue 1-2/2018
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI
https://doi.org/10.1007/s10911-018-9394-2

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