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01-01-2018 | Original Article

Does surgical delay for radical prostatectomy affect biochemical recurrence? A retrospective analysis from a Canadian cohort

Authors: Marc Zanaty, Mansour Alnazari, Khaled Ajib, Kelsey Lawson, Mounsif Azizi, Emad Rajih, Abdullah Alenizi, Pierre-Alain Hueber, Côme Tolmier, Malek Meskawi, Fred Saad, Raisa S. Pompe, Pierre I. Karakiewicz, Assaad El-Hakim, Kevin C. Zorn

Published in: World Journal of Urology | Issue 1/2018

Abstract

Aim

We sought to explore the impact of surgical wait time (SWT) to robot-assisted radical prostatectomy (RARP) on biochemical recurrence (BCR).

Method

Retrospective review of a prospectively collected database between 2006 and 2015 was conducted on all RARP cases. SWT was defined as period from prostate biopsy to surgery. Primary outcome was the impact on BCR, which was defined as two consecutive PSA ≥ 0.2 ng/dl, or salvage external beam radiation therapy and/or salvage androgen deprivation therapy. Patients were stratified according to D’Amico risk categories. Univariable analysis (UVA) and multivariable analyses (MVA) with a Cox proportional hazards regression model were used to evaluate the effect of SWT and other predictive factors on BCR, in each D’Amico risk group and on the overall collective sample.

Results

Patients eligible for analysis were 619. Mean SWT was 153, 169, 150, and 125 days, for overall, low-, intermediate-, and high-risk patients, respectively. Multivariate analysis on the overall cohort did not show a significant relation between SWT and BCR. On subgroup analysis of D’Amico risk group, SWT was positively correlated to BCR for high-risk group (p = 0.001). On threshold analysis, cut-off was found to be 90 days. SWT did not significantly affect BCR on UVA and MVA in the low- and intermediate-risk groups.

Conclusion

Increased delay to surgery could affect the BCR, as there was a positive association in high-risk group. Further studies with longer follow-up are necessary to assess the impact of wait time on BCR, cancer specific survival and overall survival.

Canadian Cancer Society’s Advisory Committee on Cancer Statistics. Canadian Cancer Statistics 2015. Toronto, ON: Canadian Cancer Society; 2015. Google Search. https://www.google.com/search?q=google+tranlate&ie=utf-8&oe=utf-8#q=Canadian+Cancer+Society%E2%80%99s+Advisory+Committee+on+Cancer+Statistics.+Canadian+Cancer+Statistics+2015.+Toronto,+ON:+Canadian+Cancer+Society;+2015.&*. Accessed 12 March 2017

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Title: Does surgical delay for radical prostatectomy affect biochemical recurrence? A retrospective analysis from a Canadian cohort
Authors: Marc Zanaty
Mansour Alnazari
Khaled Ajib
Kelsey Lawson
Mounsif Azizi
Emad Rajih
Abdullah Alenizi
Pierre-Alain Hueber
Côme Tolmier
Malek Meskawi
Fred Saad
Raisa S. Pompe
Pierre I. Karakiewicz
Assaad El-Hakim
Kevin C. Zorn
Publication date: 01-01-2018
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 1/2018
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-017-2105-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Does surgical delay for radical prostatectomy affect biochemical recurrence? A retrospective analysis from a Canadian cohort

Abstract

Aim

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Aim

Method

Results

Conclusion

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