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Journal of Assisted Reproduction and Genetics

Published in:

01-01-2016 | Assisted Reproduction Technologies

Does reducing gamete co-incubation time improve clinical outcomes: a retrospective study

Authors: Rui-Qi Li, Neng-Yong Ouyang, Song-Bang Ou, Ren-Min Ni, Mei-Qi Mai, Qing-Xue Zhang, Dong-Zi Yang, Wen-Jun Wang

Published in: Journal of Assisted Reproduction and Genetics | Issue 1/2016

Abstract

Purpose

The objective of this retrospective study was to determine whether patients undergoing in vitro fertilization (IVF) benefit from reducing the gamete co-incubation time.

Methods

Patients (n = 570) were enrolled, including 281 patients in the reduced incubation time group (2-h incubation) and 289 patients in the standard IVF group (18-h incubation).

Results

The observed outcomes, including the clinical pregnancy rate (CPR), implantation rate (IR), live birth rate (LBR), and miscarriage rate (MR), were similar between the two groups. When the data were divided into two subgroups based on the maternal age (≤30 and >30 years), the rates of top-quality embryos (30.83 vs. 25.89 %; p = 0.028), CPR (66.67 vs. 42.11 %; p = 0.013), and IR (41.90 vs. 31.25 %, p = 0.019) of the 2-h incubation group were significantly higher in the younger subgroup. However, for older patients, only a lower MR (7.59 vs. 20.83 %; p = 0.019) was achieved. Reducing the time of incubation still improved the CPR (OR = 1.993, 95 % CI 1.141–3.480) and MR (OR = 3.173, 95 % CI 1.013–9.936) in the younger and older subgroups, respectively, after it was adjusted for potential confounders.

Conclusions

Reducing incubation time improves the clinical results of IVF, although the LBR is not statistically different between the 2- and 18-h incubation time groups. And the specific clinical outcomes of reducing incubation time varied between the >30-year-old and the ≤30-year-old.

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Title: Does reducing gamete co-incubation time improve clinical outcomes: a retrospective study
Authors: Rui-Qi Li
Neng-Yong Ouyang
Song-Bang Ou
Ren-Min Ni
Mei-Qi Mai
Qing-Xue Zhang
Dong-Zi Yang
Wen-Jun Wang
Publication date: 01-01-2016
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 1/2016
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-015-0618-8

At a glance: The STEP trials

Springer Medicine

Does reducing gamete co-incubation time improve clinical outcomes: a retrospective study

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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