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World Journal of Surgery

Published in:

01-10-2010

Does Pringle Maneuver Affect Survival in Patients with Colorectal Liver Metastases?

Authors: Alessandro Ferrero, Nadia Russolillo, Luca Viganò, Roberto Lo Tesoriere, Andrea Muratore, Lorenzo Capussotti

Published in: World Journal of Surgery | Issue 10/2010

Abstract

Background

The purpose of this original article was to evaluate the impact of the Pringle maneuver on the survival of patients with colorectal liver metastases.

Methods

Eighty patients with colorectal liver metastases were randomized to undergo hepatectomy with (39 patients, HPC group) or without (41 patients, NHPC group) pedicle clamping.

Results

The two groups were homogeneous. Mortality and morbidity rates were similar. Blood transfusions rates were higher in HPC group (p = 0.010). Median follow-up was 67.1 ± 20 months in the HPC group and 77.5 ± 16.6 months in the other group (p = 0.07). Overall survival at 1, 3, and 5 years was 100%, 86.1%, and 49.4% in HPC group vs. 92.6%, 65.8%, and 48.2% in NHPC group (p = 0.704). Disease-free survival was similar between the two groups: 1-, 3- and 5-year survival rates were 85.7%, 51.4%, and 34.3% in the HPC group vs. 84%, 51.5%, and 37.9% in NHPC group (p = 0.943). The incidence of hepatic recurrence was similar in the two groups (p = 0.506). Median time to hepatic recurrence was similar in the two groups (p = 0.482). Overall and disease-free survival rates were similar even when the Pringle maneuver was longer than 45 min (p = 0.571 and 0.948) and in patients with liver steatosis (p = 0.779 and 0.412).

Conclusions

The Pringle maneuver does not seem to affect the survival of patients with liver metastases.

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Title: Does Pringle Maneuver Affect Survival in Patients with Colorectal Liver Metastases?
Authors: Alessandro Ferrero
Nadia Russolillo
Luca Viganò
Roberto Lo Tesoriere
Andrea Muratore
Lorenzo Capussotti
Publication date: 01-10-2010
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 10/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-010-0682-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Does Pringle Maneuver Affect Survival in Patients with Colorectal Liver Metastases?

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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