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Published in: Archives of Gynecology and Obstetrics 3/2013

01-03-2013 | Maternal-Fetal Medicine

Does mode of delivery affect neonate oxidative stress in parturition? Review of literature

Authors: Oshra Saphier, Naomi Schneid-Kofman, Eldad Silberstein, Tali Silberstein

Published in: Archives of Gynecology and Obstetrics | Issue 3/2013

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Abstract

Purpose

The production of reactive oxygen substances plays an important regulatory role in many physiologic reproductive processes. Excessive production may lead to oxidative stress (OS), and bring about pregnancy disorders. Growing evidence indicates that OS plays a major role in the pathophysiology of complications such as early pregnancy loss, placental insufficiency, preeclampsia, fetal growth restriction, and neonatal complications. Whether parturition induces oxidative stress is in dispute. In this review, we elaborate the influence of mode of delivery (vaginal delivery or cesarean delivery) on oxidative stress of neonates.

Methods

A review of old and recent literature was done. The studies were divided according to the impact of mode of delivery on oxidative stress in the newborn.

Results

There is a divergence in the oxidative stress production according to the mode of delivery.

Conclusions

In view of neonatal oxidative stress measures, no major difference was found between uncomplicated vaginal delivery and elective cesarean section.
Literature
1.
go back to reference Gutteridge M.C, Westermarck T, Halliwell B (1986) Oxygen damage in biological systems. In: Free radical, aging, and degenerative diseases, vol 8. Modern Aging Research. Alan R. Liss, New York, pp 99–139 Gutteridge M.C, Westermarck T, Halliwell B (1986) Oxygen damage in biological systems. In: Free radical, aging, and degenerative diseases, vol 8. Modern Aging Research. Alan R. Liss, New York, pp 99–139
2.
go back to reference Agarwal A, Gupta S, Sekhon L, Shah R (2008) Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications. Antioxid Redox Signal 10:1375–1403PubMedCrossRef Agarwal A, Gupta S, Sekhon L, Shah R (2008) Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications. Antioxid Redox Signal 10:1375–1403PubMedCrossRef
3.
go back to reference Poston L, Igosheva N, Mistry HD, Seed PT, Shennan AH, Rana S, Karumanchi SA, Chappell LC (2011) Role of oxidative stress and antioxidant supplementation in pregnancy disorders. Am J Clin Nutr 94:1980s–1985sPubMedCrossRef Poston L, Igosheva N, Mistry HD, Seed PT, Shennan AH, Rana S, Karumanchi SA, Chappell LC (2011) Role of oxidative stress and antioxidant supplementation in pregnancy disorders. Am J Clin Nutr 94:1980s–1985sPubMedCrossRef
4.
5.
go back to reference Saugstad OD (2003) Bronchopulmonary dysplasia—oxidative stress and antioxidants. Semin Neonatol 8:39–49PubMedCrossRef Saugstad OD (2003) Bronchopulmonary dysplasia—oxidative stress and antioxidants. Semin Neonatol 8:39–49PubMedCrossRef
6.
go back to reference Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, Chaiworapongsa T, Mazor M (2006) The preterm parturition syndrome. BJOG 113(3):17–42 Review Erratum in: BJOG. 2008;115:674–5PubMedCrossRef Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, Chaiworapongsa T, Mazor M (2006) The preterm parturition syndrome. BJOG 113(3):17–42 Review Erratum in: BJOG. 2008;115:674–5PubMedCrossRef
7.
go back to reference Miller SL, Wallace EM, Walker DW (2012) Antioxidant therapies: a potential role in perinatal medicine. Neuroendocrinology 96(1):13–23 (Epub Feb 29)PubMedCrossRef Miller SL, Wallace EM, Walker DW (2012) Antioxidant therapies: a potential role in perinatal medicine. Neuroendocrinology 96(1):13–23 (Epub Feb 29)PubMedCrossRef
8.
go back to reference Mongelli M, Wang CC, Wang W (1997) Oxygen free radical activity in the second stage of labour. Acta Obstet Gynecol Scand 76:765–768PubMedCrossRef Mongelli M, Wang CC, Wang W (1997) Oxygen free radical activity in the second stage of labour. Acta Obstet Gynecol Scand 76:765–768PubMedCrossRef
9.
go back to reference Mehmetoglu I, Kart A, Caglayan O, Capar M, Gokce R (2002) Oxidative stress mothers and their newborns in different types of labour. Turk J Med Sci 32:427–429 Mehmetoglu I, Kart A, Caglayan O, Capar M, Gokce R (2002) Oxidative stress mothers and their newborns in different types of labour. Turk J Med Sci 32:427–429
10.
go back to reference Rogers MS, Mongelli M, Tsang KH et al (1999) Fetal and maternal levels of lipid peroxides in term pregnancies. Acta Obstet Gynecol Scand 78:120–124PubMedCrossRef Rogers MS, Mongelli M, Tsang KH et al (1999) Fetal and maternal levels of lipid peroxides in term pregnancies. Acta Obstet Gynecol Scand 78:120–124PubMedCrossRef
11.
go back to reference Cindriva Davies T, Yung HW, Johns J, Spasic Boskovic O, Korolchuk S, Jauniaux E, Burton GJ, Charnock Jones DS (2007) Oxidative stress, gene expression, and protein changes induced in the human placenta during labor. Am J Pathol 171:1168–1179CrossRef Cindriva Davies T, Yung HW, Johns J, Spasic Boskovic O, Korolchuk S, Jauniaux E, Burton GJ, Charnock Jones DS (2007) Oxidative stress, gene expression, and protein changes induced in the human placenta during labor. Am J Pathol 171:1168–1179CrossRef
12.
go back to reference Hung TH, Chen SF, Hsieh TT, Lo LM, Li MJ, Yeh YL (2011) The associations between labor and delivery mode and maternal and placental oxidative stress. Reprod Toxicol 31:144–150PubMedCrossRef Hung TH, Chen SF, Hsieh TT, Lo LM, Li MJ, Yeh YL (2011) The associations between labor and delivery mode and maternal and placental oxidative stress. Reprod Toxicol 31:144–150PubMedCrossRef
13.
go back to reference Vakilian K, Ranjbar A, Zarganjfard A, Mortazavi M, Vosough-Ghanbari S, Mashaiee S, Abdollahi M (2009) On the relation of oxidative stress in delivery mode in pregnant women; a toxicological concern. Toxicol Mech Methods 19:94–99PubMedCrossRef Vakilian K, Ranjbar A, Zarganjfard A, Mortazavi M, Vosough-Ghanbari S, Mashaiee S, Abdollahi M (2009) On the relation of oxidative stress in delivery mode in pregnant women; a toxicological concern. Toxicol Mech Methods 19:94–99PubMedCrossRef
14.
go back to reference Greco A, Minghetti L, Puopolo M, Pietrobon B, Franzoi M, Chiandetti L, Suppiej A (2007) Plasma levels of 15-F(2t)-isoprostane in newborn infants are affected by mode of delivery. Clin Biochem 40:1420–1422PubMedCrossRef Greco A, Minghetti L, Puopolo M, Pietrobon B, Franzoi M, Chiandetti L, Suppiej A (2007) Plasma levels of 15-F(2t)-isoprostane in newborn infants are affected by mode of delivery. Clin Biochem 40:1420–1422PubMedCrossRef
15.
go back to reference Rogers MS, Mongelli JM, Tsang B, Wang CC, Law KP (1998) Lipid peroxidation in cord blood at birth: the effect of labor. Br J Obstet Gynaecol 105:739–744PubMedCrossRef Rogers MS, Mongelli JM, Tsang B, Wang CC, Law KP (1998) Lipid peroxidation in cord blood at birth: the effect of labor. Br J Obstet Gynaecol 105:739–744PubMedCrossRef
16.
go back to reference Mocatta TJ, Winterbourn CC, Inder TE, Darlow BA (2004) The effect of gestational age and labour on markers of lipid and protein oxidation in cord plasma. Free Radic Res 38:185–191PubMedCrossRef Mocatta TJ, Winterbourn CC, Inder TE, Darlow BA (2004) The effect of gestational age and labour on markers of lipid and protein oxidation in cord plasma. Free Radic Res 38:185–191PubMedCrossRef
17.
go back to reference Sridhar MG, Setia S, John M, Bhat V, Nandeesha H, Sathiyapriya V (2007) Oxidative stress varies with the mode of delivery in intrauterine growth retardation: association with Apgar score. Clin Biochem 40:688–691PubMedCrossRef Sridhar MG, Setia S, John M, Bhat V, Nandeesha H, Sathiyapriya V (2007) Oxidative stress varies with the mode of delivery in intrauterine growth retardation: association with Apgar score. Clin Biochem 40:688–691PubMedCrossRef
18.
go back to reference Mutlu B, Aksoy N, Cakir H, Celik H, Erel O (2011) The effects of the mode of delivery on oxidative—antioxidative balance. J Matern Fetal Neonatal Med 24:1367–1370PubMedCrossRef Mutlu B, Aksoy N, Cakir H, Celik H, Erel O (2011) The effects of the mode of delivery on oxidative—antioxidative balance. J Matern Fetal Neonatal Med 24:1367–1370PubMedCrossRef
19.
go back to reference Paamoni-Keren O, Silberstein T, Burg A, Raz I, Mazor M, Saphier O, Weintraub AY (2007) Oxidative stress as determined by glutathione (GSH) concentrations in venous cord blood in elective cesarean delivery versus uncomplicated vaginal delivery. Arch Gynecol Obstet 276:43–46PubMedCrossRef Paamoni-Keren O, Silberstein T, Burg A, Raz I, Mazor M, Saphier O, Weintraub AY (2007) Oxidative stress as determined by glutathione (GSH) concentrations in venous cord blood in elective cesarean delivery versus uncomplicated vaginal delivery. Arch Gynecol Obstet 276:43–46PubMedCrossRef
20.
go back to reference Compagnoni G, Lista G, Giuffrè B, Mosca F, Marini A (2004) Coenzyme Q10 levels in maternal plasma and cord blood: correlations with mode of delivery. Biol Neonate 86:104–107PubMedCrossRef Compagnoni G, Lista G, Giuffrè B, Mosca F, Marini A (2004) Coenzyme Q10 levels in maternal plasma and cord blood: correlations with mode of delivery. Biol Neonate 86:104–107PubMedCrossRef
21.
go back to reference Fogel I, Pinchuk I, Kupferminc MJ, Lichtenberg D, Fainaru O (2005) Oxidative stress in the fetal circulation does not depend on mode of delivery. Am J Obstet Gynecol 193:241–246PubMedCrossRef Fogel I, Pinchuk I, Kupferminc MJ, Lichtenberg D, Fainaru O (2005) Oxidative stress in the fetal circulation does not depend on mode of delivery. Am J Obstet Gynecol 193:241–246PubMedCrossRef
22.
go back to reference Vlachos GD, Bartzeliotou A, Schulpis KH, Partsinevelos GA, Lazaropoulou C, Papadima C, Papastamataki M, Antsaklis A, Papassotiriou I (2006) Maternal-neonatal serum paraoxonase 1 activity in relation to the mode of delivery. Clin Biochem 39:923–928PubMedCrossRef Vlachos GD, Bartzeliotou A, Schulpis KH, Partsinevelos GA, Lazaropoulou C, Papadima C, Papastamataki M, Antsaklis A, Papassotiriou I (2006) Maternal-neonatal serum paraoxonase 1 activity in relation to the mode of delivery. Clin Biochem 39:923–928PubMedCrossRef
23.
go back to reference Schulpis KH, Margeli A, Akalestos A, Vlachos GD, Partsinevelos GA, Papastamataki M, Antsaklis A, Papassotiriou I (2006) Effects of mode of delivery on maternal-neonatal plasma antioxidant status and on protein S100B serum concentrations. Scand J Clin Lab Invest 66:733–742PubMedCrossRef Schulpis KH, Margeli A, Akalestos A, Vlachos GD, Partsinevelos GA, Papastamataki M, Antsaklis A, Papassotiriou I (2006) Effects of mode of delivery on maternal-neonatal plasma antioxidant status and on protein S100B serum concentrations. Scand J Clin Lab Invest 66:733–742PubMedCrossRef
Metadata
Title
Does mode of delivery affect neonate oxidative stress in parturition? Review of literature
Authors
Oshra Saphier
Naomi Schneid-Kofman
Eldad Silberstein
Tali Silberstein
Publication date
01-03-2013
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 3/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-012-2619-5

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