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Archives of Gynecology and Obstetrics

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01-06-2012 | General Gynecology

Does hormone replacement therapy have beneficial effects on renal functions in menopausal women?

Authors: Ikbal Kaygusuz, Ilknur Inegol Gumus, Hilal Uslu Yuvaci, Benan Kasapoğlu, Ayse Carlioglu

Published in: Archives of Gynecology and Obstetrics | Issue 6/2012

Abstract

Background

The study was carried out to evaluate the possible effects of hormone replacement therapy (HRT) on renal functions in postmenopausal women.

Methods

A total of 85 postmenopausal women without a history of medical illness were enrolled in the study. They were divided into HRT users and control groups. After 30 weeks of HRT use, the changes in serum urea, creatinine, uric acid, urinary protein, urinary creatinine, urinary protein/creatinine ratio and glomerular filtration rate (GFR) (mL/min/1.73 m²) were evaluated.

Results

HRT was associated with statistically significant increases in glomerular filtration rate (p < 0.01), while serum urea, creatinine, uric acid, urinary protein, urinary creatinine and urinary protein/creatinine ratio did not change significantly in both groups.

Conclusion

In our study, we suggested that usage of hormone replacement therapy appeared to affect renal functions in postmenopausal women. There were beneficial effects of HRT on GFR in our postmenopausal patients. HRT may have possible protective mechanisms for kidney against adverse effects of aging.

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Title: Does hormone replacement therapy have beneficial effects on renal functions in menopausal women?
Authors: Ikbal Kaygusuz
Ilknur Inegol Gumus
Hilal Uslu Yuvaci
Benan Kasapoğlu
Ayse Carlioglu
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 6/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2215-8

At a glance: The STEP trials

Springer Medicine

Does hormone replacement therapy have beneficial effects on renal functions in menopausal women?

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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