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Obesity Surgery
Published in: Obesity Surgery 2/2008

01-02-2008 | Research Article

Does Biliopancreatic Diversion Carry Increased Risk for Colorectal Cancer? A Cohort Study

Authors: Gian Franco Adami, Francesco S. Papadia, Giuseppe M. Marinari, Giovanni B. Camerini, Nicola Scopinaro

Published in: Obesity Surgery | Issue 2/2008

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Abstract

Background

Because of the rearrangement of the gastrointestinal tract, biliopancreatic diversion (BPD) could lead to an increased risk of colorectal cancer caused by possible carcinogenetic action of the unabsorbed food and bile acid on colonic mucosa.

Methods

The incidence of colorectal cancer in 1,898 obese subjects submitted to BPD from May 76 to July 2002 with a minimum follow-up of 5 years was retrospectively evaluated.

Results

Among 28,811 person-years, seven cases of colorectal cancer were detected, for an overall incidence of 29.4 per 100,000, which is not different from that observed in the general Italian population, and lower than that reported for obese and type 2 diabetes patients. Logistic regression model suggests that occurrence of colorectal cancer is positively related to the time elapsed from BPD.

Conclusion

This study indicates that BPD does not carry any increased risk for colorectal cancer. The complete postoperative restoration of insulin sensibility could exert a valuable protective action.
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Metadata
Title
Does Biliopancreatic Diversion Carry Increased Risk for Colorectal Cancer? A Cohort Study
Authors
Gian Franco Adami
Francesco S. Papadia
Giuseppe M. Marinari
Giovanni B. Camerini
Nicola Scopinaro
Publication date
01-02-2008
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 2/2008
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-007-9348-z

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